RT Journal
A1 Sadri-Ardekani H, Akhondi MA, van der Veen F, Repping S, van Pelt AM
T1 IN vitro propagation of human prepubertal spermatogonial stem cells
JF JAMA
JO JAMA
YR 2011
FD June 15
VO 305
IS 23
SP 2416
OP 2418
DO 10.1001/jama.2011.791
UL http://dx.doi.org/10.1001/jama.2011.791
AB 
To the Editor: Treatment of pediatric cancer has continuously improved over the past decades, but fertility is often compromised in survivors of childhood cancer. Fertility preservation in prepubertal boys with cancer could theoretically be achieved by cryopreserving testicular tissue before cancer treatment, and then propagating and autotransplanting spermatogonial stem cells (SSCs) from this tissue.1 We describe in vitro propagation of human prepubertal SSCs using a culture system for adult human SSCs.2