RT Journal A1 Friedrich MJ T1 DEbate continues on use of psa testing for early detection of prostate cancer JF JAMA JO JAMA YR 2011 FD June 8 VO 305 IS 22 SP 2273 OP 2276 DO 10.1001/jama.2011.777 UL http://dx.doi.org/10.1001/jama.2011.777 AB Prostate cancer appears in a large percentage of men as they age, but is indolent most of the time. Critics emphasize that PSA testing is an imperfect screening tool because it does not differentiate clinically significant tumors from ones that would never cause harm, and the result is overdiagnosis and overtreatment. Others defend the use of PSA testing and say that a more rational, evidence-based approach to using it can help detect and treat prostate cancer early in men who would die of the disease.