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VITAMIN DEFICIENCIES AND NERVOUS SYSTEM LESIONS FREE

JAMA. 1932;99(2):137-137. doi:10.1001/jama.1932.02740540045015
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Since Eijkman1 showed that noninflammatory atrophic degeneration of the medullary sheaths of peripheral nerves occurred in hens fed on a diet of polished rice, it has been known that dietary deficiencies cause lesions of the nervous system. The factor responsible for this particular morphologic change was shown by Woollard2 and others to be produced by a deficiency of vitamin B. Recently it has been found that what has heretofore been called vitamin B is really a mixture of at least two components; namely, the heat-labile antineuritic factor and a thermostable substance, the absence of which is thought to produce pellagra. Stern and Findlay3 studied the changes in the nervous system of rats fed diets deficient in vitamin B (antineuritic component) and G (pellagra-preventive factor), respectively. In the first group of animals, they found chromatolytic changes in the ganglion cells of the spinal cord and early degeneration of

REFERENCES

Eijkman, Christiaan:  Eine beriberiähnliche Krankheit der Hühner , Virchows Arch. f. path. Anat. 148: 523, 1897;.
Woollard, H. H.:  The Nature of the Structural Changes in Nerve Endings in Starvation and in Beriberi , J. Anat. 61: 283 ( (April) ) 1927;.
Stern, R. O., and Findlay, G. M.:  The Nervous System in Rats Fed on Diets Deficient in Vitamins B1 and B2 , J. Path. & Bact. 32: 63 ( (Jan.) ) 1929;.
Zimmerman, H. M., and Burack, Ethel:  Lesions of the Nervous System Resulting from Deficiency of the Vitamin B Complex , Arch. Path. 13: 207 ( (Feb.) ) 1932;.
Winkelman, N. W.:  Beiträge zur Neurohistopathologie der Pellagra , Ztschr. f. d. ges. Neurol. u. Psychiat. 102: 38, 1926;.
Pentschew, A.:  Ueber die Histopathologie des Zentralnervensystems bei der Psychosis pellagrosa , Ztschr. f. d. ges. Neurol. u. Psychiat. 118: 17, 1928;.
Langworthy, O. R.:  Lesions of the Central Nervous System Characteristic of Pellagra , Brain 54: 291 ( (Sept.) ) 1931;.
Pappenheimer, A. M., and Goettsch, M.:  A Cerebellar Disorder in Chicks, Apparently of Nutritional Origin , J. Exper. Med. 53:11 ( (Jan.) ) 1931;.
Mellanby, Edward:  The Experimental Production and Prevention of Degeneration in the Spinal Cord , Brain 54: 247 ( (Sept.) ) 1931;.
Hess, A. F.:  Focal Degeneration of the Lumbar Cord in a Case of Infantile Scurvy , J. Infect. Dis. 23: 438 ( (Nov.) ) 1918;.

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Eijkman, Christiaan:  Eine beriberiähnliche Krankheit der Hühner , Virchows Arch. f. path. Anat. 148: 523, 1897;.
Woollard, H. H.:  The Nature of the Structural Changes in Nerve Endings in Starvation and in Beriberi , J. Anat. 61: 283 ( (April) ) 1927;.
Stern, R. O., and Findlay, G. M.:  The Nervous System in Rats Fed on Diets Deficient in Vitamins B1 and B2 , J. Path. & Bact. 32: 63 ( (Jan.) ) 1929;.
Zimmerman, H. M., and Burack, Ethel:  Lesions of the Nervous System Resulting from Deficiency of the Vitamin B Complex , Arch. Path. 13: 207 ( (Feb.) ) 1932;.
Winkelman, N. W.:  Beiträge zur Neurohistopathologie der Pellagra , Ztschr. f. d. ges. Neurol. u. Psychiat. 102: 38, 1926;.
Pentschew, A.:  Ueber die Histopathologie des Zentralnervensystems bei der Psychosis pellagrosa , Ztschr. f. d. ges. Neurol. u. Psychiat. 118: 17, 1928;.
Langworthy, O. R.:  Lesions of the Central Nervous System Characteristic of Pellagra , Brain 54: 291 ( (Sept.) ) 1931;.
Pappenheimer, A. M., and Goettsch, M.:  A Cerebellar Disorder in Chicks, Apparently of Nutritional Origin , J. Exper. Med. 53:11 ( (Jan.) ) 1931;.
Mellanby, Edward:  The Experimental Production and Prevention of Degeneration in the Spinal Cord , Brain 54: 247 ( (Sept.) ) 1931;.
Hess, A. F.:  Focal Degeneration of the Lumbar Cord in a Case of Infantile Scurvy , J. Infect. Dis. 23: 438 ( (Nov.) ) 1918;.
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