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Blood Transfusion After Coronary Artery Bypass Graft Surgery

Barry Dixon, MD, PhD; John D. Santamaria, MD
JAMA. 2011;305(2):149-150. doi:10.1001/jama.2010.1956
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To the Editor: Dr Bennett-Guerrero and colleagues1 observed a marked variation among hospitals in the use of blood transfusion following coronary artery bypass graft (CABG) surgery. The authors considered inconsistency in transfusion practices as a possible explanation for these differences. However, another important factor may have been variation in the extent of bleeding.

The extent of chest tube bleeding varies among patients and is correlated with red cell transfusion.2 Previous studies and meta-analysis have demonstrated marked variations in the extent of bleeding among surgeons undertaking similar cases.2 3 Moreover, the Sixth Report of the National Adult Cardiac Surgery Database for Great Britain and Ireland also found wide variation among centers in the extent of bleeding complications requiring re-operation (0.5% to 6%).4 We believe much of the unexplained variation found in this study may be due to differences in bleeding. Changes in surgical practices to minimize bleeding may provide another approach to reduce the need for blood transfusion.5

AUTHOR INFORMATION

Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.

REFERENCES

Bennett-Guerrero E, Zhao Y, O’Brien SM,  et al.  Variation in use of blood transfusion in coronary artery bypass graft surgery.  JAMA. 2010;304(14):1568-1575
PubMedCrossRef
Dial S, Delabays E, Albert M,  et al.  Hemodilution and surgical hemostasis contribute significantly to transfusion requirements in patients undergoing coronary artery bypass.  J Thorac Cardiovasc Surg. 2005;130(3):654-661
PubMedCrossRef
Carless PA, Moxey AJ, Stokes BJ, Henry DA. Are antifibrinolytic drugs equivalent in reducing blood loss and transfusion in cardiac surgery? a meta-analysis of randomized head-to-head trials.  BMC Cardiovasc Disord. 2005;519
PubMedCrossRef
Bridgewater B, Keogh B, Kinsman R, Walton P. Sixth National Adult Cardiac Surgery Database Report. http://www.scts.org/documents/PDF/Sixth_NACSD_report_2008_with_c.pdf. Accessed December 10, 2010
Helm RE, Rosengart TK, Gomez M,  et al.  Comprehensive multimodality blood conservation: 100 consecutive CABG operations without transfusion.  Ann Thorac Surg. 1998;65(1):125-136
PubMedCrossRef

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Bennett-Guerrero E, Zhao Y, O’Brien SM,  et al.  Variation in use of blood transfusion in coronary artery bypass graft surgery.  JAMA. 2010;304(14):1568-1575
PubMedCrossRef
Dial S, Delabays E, Albert M,  et al.  Hemodilution and surgical hemostasis contribute significantly to transfusion requirements in patients undergoing coronary artery bypass.  J Thorac Cardiovasc Surg. 2005;130(3):654-661
PubMedCrossRef
Carless PA, Moxey AJ, Stokes BJ, Henry DA. Are antifibrinolytic drugs equivalent in reducing blood loss and transfusion in cardiac surgery? a meta-analysis of randomized head-to-head trials.  BMC Cardiovasc Disord. 2005;519
PubMedCrossRef
Bridgewater B, Keogh B, Kinsman R, Walton P. Sixth National Adult Cardiac Surgery Database Report. http://www.scts.org/documents/PDF/Sixth_NACSD_report_2008_with_c.pdf. Accessed December 10, 2010
Helm RE, Rosengart TK, Gomez M,  et al.  Comprehensive multimodality blood conservation: 100 consecutive CABG operations without transfusion.  Ann Thorac Surg. 1998;65(1):125-136
PubMedCrossRef
January 12, 2011
Elliott Bennett-Guerrero, MD; T. B. Ferguson, MD; Howard K. Song, MD, PhD
JAMA. 2011;305(2):149-150. doi:10.1001/jama.2010.1957.
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