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Randomized Controlled Trials With Statistically Nonsignificant Results

David B. Allison, PhD; Mark B. Cope, PhD
JAMA. 2010;304(9):965-965. doi:10.1001/jama.2010.1245
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To the Editor: In their study, Dr Boutron and colleagues1 discussed the inappropriate use of “spin” in public reports of randomized controlled trials. Given the importance of the topic of distorted publishing2 and interest in the field about possible associations between industry funding and reporting quality,3 we particularly noted the authors' statement, “Our results are consistent with those of other related studies showing a positive relation between financial ties and favorable conclusions stated in trial reports.”

Although this implies an analysis of the association between source of funding and reporting, in particular on the use of spin, such an analysis was not included in the article. The authors noted in the “Methods” section that they assessed source of funding. It would therefore be helpful if the authors could examine this relationship.

AUTHOR INFORMATION

Financial Disclosures: Dr Allison reported receiving grants, contracts, honoraria, expense reimbursements, royalties, donations, and consulting fees from numerous nonprofit and for-profit organizations with interests in research reporting in general and clinical trials in particular. Dr Cope reported being employed by a for-profit organization and also having received grants, contracts, expense reimbursements, honoraria, donations, and consulting fees from numerous nonprofit and for-profit organizations with interests in research reporting in general and clinical trials in particular.

REFERENCES

Boutron I, Dutton S, Ravaud P, Altman DG. Reporting and interpretation of randomized controlled trials with statistically nonsignificant results for primary outcomes.  JAMA. 2010;303(20):2058-2064
PubMedCrossRef
Cope MB, Allison DB. White hat bias: examples of its presence in obesity research and a call for renewed commitment to faithfulness in research reporting.  Int J Obes (Lond). 2010;34(1):84-88
PubMedCrossRef
Thomas O, Thabane L, Douketis J, Chu R, Westfall AO, Allison DB. Industry funding and the reporting quality of large long-term weight loss trials.  Int J Obes (Lond). 2008;32(10):1531-1536
PubMedCrossRef

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Boutron I, Dutton S, Ravaud P, Altman DG. Reporting and interpretation of randomized controlled trials with statistically nonsignificant results for primary outcomes.  JAMA. 2010;303(20):2058-2064
PubMedCrossRef
Cope MB, Allison DB. White hat bias: examples of its presence in obesity research and a call for renewed commitment to faithfulness in research reporting.  Int J Obes (Lond). 2010;34(1):84-88
PubMedCrossRef
Thomas O, Thabane L, Douketis J, Chu R, Westfall AO, Allison DB. Industry funding and the reporting quality of large long-term weight loss trials.  Int J Obes (Lond). 2008;32(10):1531-1536
PubMedCrossRef
September 1, 2010
Isabelle Boutron, MD, PhD; Philippe Ravaud, MD, PhD; Douglas G. Altman, DSc
JAMA. 2010;304(9):965-965.
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