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Treadmill Exercise or Resistance Training in Patients With Peripheral Arterial Disease

Saakshi Khattri, MD
JAMA. 2009;301(19):1986-1987. doi:10.1001/jama.2009.649
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To the Editor: Dr McDermott and colleagues1 reported the results of a randomized trial of treadmill exercise or resistance training in patients with peripheral arterial disease (PAD), a prevalent condition. I am interested in knowing what medications the participants were using. Drugs such as aspirin, cilostazol, pentoxifylline, and clopidogrel that are used for PAD could have altered the outcome of the study. There may be improved walking distances with both cilostazol and pentoxifylline in comparison with placebos.2 4

Also, the baseline performance characteristics of the treadmill exercise group were better than both the control group and the lower extremity resistance training group despite randomization. Although these differences did not reach statistical significance, in aggregate they could have affected the study outcomes.

AUTHOR INFORMATION

Financial Disclosures: None reported.

REFERENCES

McDermott MM, Ades P, Guralnik JM,  et al.  Treadmill exercise and resistance training in patients with peripheral arterial disease with and without intermittent claudication.  JAMA. 2009;301(2):165-174
PubMedCrossRef
Regensteiner JG, Ware JE Jr, McCarthy WJ,  et al.  Effect of cilostazol on treadmill walking, community-based walking ability, and health-related quality of life in patients with intermittent claudication due to peripheral arterial disease: meta-analysis of six randomized controlled trials.  J Am Geriatr Soc. 2002;50(12):1939-1946
PubMedCrossRef
Money SR, Herd JA, Isaacsohn JL,  et al.  Effect of cilostazol on walking distances in patients with intermittent claudication caused by peripheral vascular disease.  J Vasc Surg. 1998;27(2):267-274
PubMedCrossRef
Creager MA. Medical management of peripheral arterial disease.  Cardiol Rev. 2001;9(4):238-245
PubMedCrossRef

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McDermott MM, Ades P, Guralnik JM,  et al.  Treadmill exercise and resistance training in patients with peripheral arterial disease with and without intermittent claudication.  JAMA. 2009;301(2):165-174
PubMedCrossRef
Regensteiner JG, Ware JE Jr, McCarthy WJ,  et al.  Effect of cilostazol on treadmill walking, community-based walking ability, and health-related quality of life in patients with intermittent claudication due to peripheral arterial disease: meta-analysis of six randomized controlled trials.  J Am Geriatr Soc. 2002;50(12):1939-1946
PubMedCrossRef
Money SR, Herd JA, Isaacsohn JL,  et al.  Effect of cilostazol on walking distances in patients with intermittent claudication caused by peripheral vascular disease.  J Vasc Surg. 1998;27(2):267-274
PubMedCrossRef
Creager MA. Medical management of peripheral arterial disease.  Cardiol Rev. 2001;9(4):238-245
PubMedCrossRef
May 20, 2009
Mary M. McDermott, MD; Alan Dyer, PhD
JAMA. 2009;301(19):1986-1987.
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