To the Editor: Dr Czarnetzki and colleagues1 reported that the use of dexamethasone resulted in a dose-dependent decreased risk of postoperative nausea and vomiting (PONV) but was associated with an increased risk of bleeding following tonsillectomy. Because postoperative hemorrhage in patients undergoing tonsillectomy has the potential to be life threatening, extensive analysis of risk factors is of general interest.
Dexamethasone, a synthetic adrenocortical steroid, is a white, odorless, crystalline powder. It is stable in air and practically insoluble in water.2 Because the authors administered dexamethasone intravenously, it is possible that dexamethasone sodium phosphate was used for injection. Additional components previously thought to be inactive could play important roles during postoperative bleeding. It would be helpful for the authors to provide more detailed pharmacological information about the administered drug to assess the conclusion drawn from this study.
Financial Disclosures: None reported.
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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