Scientists from Genentech (South San Francisco, Calif) have discovered a variant of an engineered antibody that can bind 2 proteins involved in cancer.
The researchers isolated a variant of the monoclonal antibody biologic trastuzumab, which binds to the human epidermal growth factor receptor 2 (HER2); this variant also can bind vascular endothelial growth factor (VEGF) (Bostrum J et al. Science. 2009;323[5921]:1610-1614). The scientists visualized the structure of this 2-protein–binding variant using x-ray crystallography. Additionally, they found that a trastuzumab variant with high affinity for both HER2 and VEGF can inhibit cell proliferation mediated by these 2 proteins in a human cell line and inhibit tumor progression mediated by these proteins in a mouse model.
Grahic Jump Location
Researchers have found a variant of trastuzumab that can bind both human epidermal growth factor receptor 2 (HER2) and vascular endothelial growth factor (VEGF).
The authors said that clinical trials are currently under way to evaluate whether simultaneous treatment with trastuzumab and bevacizumab, a VEGF-targeting antibody, improves outcomes in patients with breast cancer. They noted that if this combination does offer a benefit, an antibody that can bind both proteins should be further studied as a potential therapy.
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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