Financial Disclosures: Drs Henschke and Yankelevitz reported being listed as co-inventors for the following patent and patent applications: US Patent No. 7,274,810, “System and Method for Three-Dimensional Image Rendering and Analysis” (patent issued to CRF September 25, 2007); US Patent Application No. 10/245,782, “System, Method and Apparatus for Small Pulmonary Nodule Computer Aided Diagnosis from Computed Tomography Scans” (CRF pending patent application); US Patent Application No. 11/827,985, “System and Method for Three-Dimensional Image Rendering and Analysis” (CRF pending divisional application); US Patent Application No. 11/827,994, “System and Method for Three-Dimensional Image Rendering and Analysis” (CRF pending divisional application); US Patent Application No.10/688,267, “System, Method and Apparatus for Small Pulmonary Nodule Computer Aided Diagnosis from Computed Tomography Scans” (CRF pending patent application); US Patent Application No. 10/901,316, “System and Method for Providing Remote Analysis of Medical Data” (CRF pending patent application); US Patent Application No.10/932,443, “System and Method for Analyzing Medical Data to Determine Diagnosis and Treatment” (CRF pending patent application); US Patent Application No. 10/901,362, “System and Method for Conducting a Clinical Trial Study” (CRF pending patent application); US Patent Application No. 11/688,980, “Medical Imaging Visibility Index System and Method for Cancer Lesions” (CRF patent cooperation treaty application also pending); US Patent Application No. 11/377,031, “Method for Expanding the Domain of Imaging Software in a Diagnostic Workup” (CRF pending patent application) (foreign patent applications also pending); US Patent Application No. 11/858,855, “System and Method for Position Matching of a Patient for Medical Imaging” (CRF pending patent application); and “Medical Imaging System for Accurate Measurement Evaluation of Changes in a Target Lesion” (foreign patent applications pending) (Henschke/Yankelevitz pending patent application). Dr Henschke reported receiving compensation for serving as a member of a National Cancer Institute study section. Dr Yankelevitz reported being an inventor on a pending patent related to biopsy needles assigned to PneumRX, being a paid medical advisor to PneumRX, and holding stock in PneumRX.