In Reply: Ms Ross raises the interesting possibility that the substantial amount of trigonelline in coffee could contribute to the association between coffee consumption and a lower risk of type 2 diabetes. In addition to intake of trigonelline, intakes of the coffee components chlorogenic acid,1 quinides,2 and the lignan secoisolariciresinol3 improved glucose metabolism in rats. These findings underscore that it is premature to attribute the apparent protective effect of coffee consumption against the development of type 2 diabetes to 1 specific coffee component. The possibility of a contribution of several components, or of interactions between different coffee components, should also be considered.
A useful research approach would be to first attempt to confirm the epidemiological findings in a human subject intervention study of coffee consumption with appropriate outcome measures of glucose metabolism. If successful, this experimental design can be used to test whether different coffee components have the same effect on glucose metabolism as coffee. In addition, the development of a food database that includes information on coffee components such as trigonelline would allow the estimation of intakes from total diets and the epidemiological study of these compounds in relation to risk of type 2 diabetes.
Financial Disclosures: None reported.
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
Instructions
Comments are moderated and will appear on the site at the discretion of the Journal of American Medical Association editors. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest* Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Customize your page view by dragging & repositioning the boxes below.
and access these and other features:
Register Now
Enter your username and email address. We'll send you a reminder to the email address on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.