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Relationship of Fitness and Body Mass Index to Cardiac DiseaseRelationship of Fitness and Body Mass Index to Cardiac Disease

JAMA. 2005;293(2):161-162. doi:10.1001/jama.293.2.161-b
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AUTHOR INFORMATION

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

RELATIONSHIP OF FITNESS AND BODY MASS INDEX TO CARDIAC DISEASE

To the Editor: In their study of the relationship of physical fitness and body mass index to cardiac disease in women, Dr Wessel and colleagues1 incorrectly converted the Duke Activity Status Index (DASI) score to peak metabolic equivalent tasks (METs). The Methods state that the actual score from the DASI questionnaire can be divided by 3.5 to estimate METs. However, the original article on the development of the DASI2 states that weighting of items in the index was based on known metabolic costs, but the sum of the weighted answers must then be converted to VO2 peak in mL/kg per minute using the equation VO2 peak = 0.43 × DASI score + 9.6. METs can then be calculated by dividing the estimated VO2 peak by 3.5.

Converting directly from DASI score to METs, as in the study by Wessel and colleagues, overestimates METs. This is important, as the study used a DASI score of 25 or greater as the criterion for placement in the fit group, under the assumption that this score is equivalent to 7 or more METs. A DASI score of 25 converts to only 5.8 METs, calculated by converting the DASI score to a VO2 peak of 20.35 mL/kg per minute and dividing by 3.5. Therefore, the cutoff used to define fit and unfit groups in this study was actually 5.8 METs.

References
Wessel TR, Arant CB, Olson MB.  et al.  Relationship of physical fitness vs body mass index with coronary artery disease and cardiovascular events in women.  JAMA. 2004;2921179-1187
PubMed
Hlatky MA, Boineau RE, Higginbotham MB.  et al.  A brief self-administered questionnaire to determine functional capacity (the Duke Activity Status Index).  Am J Cardiol. 1989;64651-654
PubMed

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Wessel TR, Arant CB, Olson MB.  et al.  Relationship of physical fitness vs body mass index with coronary artery disease and cardiovascular events in women.  JAMA. 2004;2921179-1187
PubMed
Hlatky MA, Boineau RE, Higginbotham MB.  et al.  A brief self-administered questionnaire to determine functional capacity (the Duke Activity Status Index).  Am J Cardiol. 1989;64651-654
PubMed
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