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Adiponectin and Risk of Coronary Heart DiseaseAdiponectin and Risk of Coronary Heart Disease

JAMA. 2004;292(1):40-40. doi:10.1001/jama.292.1.40-a
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AUTHOR INFORMATION

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

ADIPONECTIN AND RISK OF CORONARY HEART DISEASE

To the Editor: Dr Pischon and colleagues1 reported an inverse association between adiponectin levels and risk of myocardial infarction and death from coronary heart disease. Although the authors measured total levels of adiponectin, several studies have suggested that only the fraction bound to high-molecular-weight complexes is related to various indicators of insulin sensitivity.2 4

Given the narrow range of the circulating levels of this abundant hormone, analysis of the fraction of adiponectin in high-molecular-weight complexes should be undertaken to establish the effect of population-based screening for total adiponectin levels.

References
Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm EB. Plasma adiponectin levels and risk of myocardial infarction in men.  JAMA.2004;291:1730-1737.
PubMed
Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte secreted protein Acrp30 enhances hepatic insulin action.  Nat Med.2001;7:947-953.
PubMed
Pajvani UB, Hawkins M, Combs TP.  et al.  Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity.  J Biol Chem.2004;279:12152-12162.
PubMed
Pajvani UB, Du X, Combs TP.  et al.  Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin: implications for metabolic regulation and bioactivity.  J Biol Chem.2003;278:9073-9085.
PubMed

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Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm EB. Plasma adiponectin levels and risk of myocardial infarction in men.  JAMA.2004;291:1730-1737.
PubMed
Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte secreted protein Acrp30 enhances hepatic insulin action.  Nat Med.2001;7:947-953.
PubMed
Pajvani UB, Hawkins M, Combs TP.  et al.  Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity.  J Biol Chem.2004;279:12152-12162.
PubMed
Pajvani UB, Du X, Combs TP.  et al.  Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin: implications for metabolic regulation and bioactivity.  J Biol Chem.2003;278:9073-9085.
PubMed
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To understand the clinical management of acute heart failure syndromes.
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