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Exercise and Risk of Breast CancerExercise and Risk of Breast Cancer

JAMA. 2003;290(24):3193-3193. doi:10.1001/jama.290.24.3193-a
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AUTHOR INFORMATION

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

EXERCISE AND RISK OF BREAST CANCER

To the Editor: Dr McTiernan and colleagues1 of the Women's Health Initiative (WHI) reported that increased physical activity was associated with a 14% decrease in the risk of breast cancer in postmenopausal women. These results were not based on a randomized trial of exercise vs no exercise, but rather were from observational data. An earlier randomized WHI study2 of estrogen plus progesterone therapy vs placebo demonstrated that the prior observational studies that had demonstrated a cardiovascular benefit for hormone therapy were incorrect. It was clear that there was a strong bias in the prior observational studies toward showing a cardiovascular benefit in the women who had selected the hormone replacement therapy intervention. Thus, it is possible that a similar bias occurred in this study as well.

References
McTiernan A, Kooperberg C, White E.  et al.  Recreational physical activity and the risk of breast cancer in postmenopausal women: the Women's Health Initiative Cohort Study.  JAMA.2003;290:1331-1336.
PubMed
Rossouw JE, Anderson GL, Prentice RL.  et al. Writing Group for the Women's Health Initiative Investigators.  Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial.  JAMA.2002;288:321-333.
PubMed

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McTiernan A, Kooperberg C, White E.  et al.  Recreational physical activity and the risk of breast cancer in postmenopausal women: the Women's Health Initiative Cohort Study.  JAMA.2003;290:1331-1336.
PubMed
Rossouw JE, Anderson GL, Prentice RL.  et al. Writing Group for the Women's Health Initiative Investigators.  Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial.  JAMA.2002;288:321-333.
PubMed
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