Scientists from England and Japan report they may have determined how powerful antimalarial drugs called artemisinins exert their killing power on the Plasmodium falciparum parasite, a finding that could aid the development of new drugs to treat malaria (Nature. 2003;424;957-961).
Artemisinins have become increasingly important as resistance to the most commonly used antimalarial medicines increases. First developed by Chinese scientists in the 1970s, these drugs' mode of action was unknown.
The investigators found that artemisinins are a potent inhibitor of a calcium-pumping enzyme called P falciparum ATP6, which is critical to the malarial parasite. Identifying this molecular target may help researchers design new artemisinin derivatives and detect emerging artemisinin resistance in the parasites.
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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