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A Woman Attempting to Discontinue Hormone TherapyA Woman Attempting to Discontinue Hormone Therapy

JAMA. 2002;288(18):2264-2265. doi:10.1001/jama.288.18.2264
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AUTHOR INFORMATION

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

A WOMAN ATTEMPTING TO DISCONTINUE HORMONE THERAPY

To the Editor: In her Clinical Crossroads article about a 60-year-old woman trying to discontinue hormone replacement therapy (HRT), Dr Grady1 did not mention behavioral interventions. My colleagues and I have found that slow, deep, abdominal breathing reduces hot flash frequency by about 50% in symptomatic, postmenopausal women.2 4 The results of these studies were documented with physiological recordings of hot flashes, in addition to patient self-reports.

Hot flashes may be triggered by small elevations in core body temperature acting within a reduced thermoneutral zone.5 6 When core temperature reaches the thresholds for sweating and peripheral vasodilation, a hot flash occurs. Therefore, procedures that reduce core body temperature, such as lowering ambient temperature and drinking cold liquids, may also reduce the occurrence of hot flashes.

References
Grady D. A 60-year-old woman trying to discontinue hormone replacement therapy.  JAMA.2002;287:2130-2137.
Germaine LM, Freedman RR. Behavioral treatment of menopausal hot flashes: evaluation by objective methods.  J Consult Clin Psychol.1984;52:1072-1079.
Freedman RR, Woodward S. Behavioral treatment of menopausal hot flushes: evaluation by ambulatory monitoring.  Am J Obstet Gynecol.1992;167:436-439.
Freedman RR, Woodward S, Brown B.  et al.  Biochemical and thermoregulatory effects of behavioral treatments for menopausal hot flashes.  Menopause.1995;2:211-218.
Freedman RR, Norton D, Woodward S.  et al.  Core body temperature and circadian rhythm of hot flashes in menopausal women.  J Clin Endocrinol Metab.1995;80:2354-2358.
Freedman RR, Krell W. Reduced thermoregulatory null zone in postmenopausal women with hot flashes.  Am J Obstet Gynecol.1999;181:66-70.

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Grady D. A 60-year-old woman trying to discontinue hormone replacement therapy.  JAMA.2002;287:2130-2137.
Germaine LM, Freedman RR. Behavioral treatment of menopausal hot flashes: evaluation by objective methods.  J Consult Clin Psychol.1984;52:1072-1079.
Freedman RR, Woodward S. Behavioral treatment of menopausal hot flushes: evaluation by ambulatory monitoring.  Am J Obstet Gynecol.1992;167:436-439.
Freedman RR, Woodward S, Brown B.  et al.  Biochemical and thermoregulatory effects of behavioral treatments for menopausal hot flashes.  Menopause.1995;2:211-218.
Freedman RR, Norton D, Woodward S.  et al.  Core body temperature and circadian rhythm of hot flashes in menopausal women.  J Clin Endocrinol Metab.1995;80:2354-2358.
Freedman RR, Krell W. Reduced thermoregulatory null zone in postmenopausal women with hot flashes.  Am J Obstet Gynecol.1999;181:66-70.
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