0
Letters |

Thiazide Use and Reduced Sodium Intake for Prevention of Osteoporosis

Robert S. Bobrow, MD
[+] Author Affiliations

Stephen J. Lurie, MD, PhDSenior Editor: IndividualAuthor
Jody W. Zylke, MDContributing Editor: IndividualAuthor

Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

More Author Information
JAMA. 2001;285(18):2323-2324. doi:10.1001/jama.285.18.2323
Text Size: A A A
Published online

To the Editor: I was disappointed that, in the National Institutes of Health (NIH) Consensus Statement on osteoporosis,1 no mention was made of data showing that thiazide diuretics prevent the disease. At usual antihypertensive doses, thiazides have been shown to preserve bone mineralization at the wrist, elbow, and heel,2 and the hip and spine.3 More importantly, the incidence of hip fracture is reduced by 30% in those patients taking thiazides.4 5

Thiazides are inexpensive and safe, but no great profits are made from their sales. Instead, physicians are bombarded with data about bisphosphonates, selective estrogen-receptor modulators, and calcitonin, which are under patent and are expensive. The studies on thiazides for the prevention of osteoporosis are equally compelling and deserve more attention.

REFERENCES

NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy,  Osteoporosis prevention, diagnosis, and therapy. JAMA. 2001;285:785-795.
Wasnich  RD, Benfante  RJ, Yano  K, Heilburn  L, Vogel  JM. Thiazide effect on the mineral content of bone. N Engl J Med. 1983;309:344-346.
LaCroix  AZ, Ott  SM, Ichikawa  L, Scholes  D, Barlow  WE. Low-dose hydrochlorothiazide and preservation of bone mineral density in older adults: a randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2000;133:516-526.
LaCroix  AZ, Wienpahl  J, White  LR.  et al.  Thiazide diuretic agents and the incidence of hip fracture. N Engl J Med. 1990;322:286-290.
Felson  DT, Sloutskis  D, Anderson  JJ, Anthony  JM, Kiel  DP. Thiazide diuretics and the risk of hip fracture: results from the Framingham Study. JAMA. 1991;265:370-373.

First Page Preview

First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy,  Osteoporosis prevention, diagnosis, and therapy. JAMA. 2001;285:785-795.
Wasnich  RD, Benfante  RJ, Yano  K, Heilburn  L, Vogel  JM. Thiazide effect on the mineral content of bone. N Engl J Med. 1983;309:344-346.
LaCroix  AZ, Ott  SM, Ichikawa  L, Scholes  D, Barlow  WE. Low-dose hydrochlorothiazide and preservation of bone mineral density in older adults: a randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2000;133:516-526.
LaCroix  AZ, Wienpahl  J, White  LR.  et al.  Thiazide diuretic agents and the incidence of hip fracture. N Engl J Med. 1990;322:286-290.
Felson  DT, Sloutskis  D, Anderson  JJ, Anthony  JM, Kiel  DP. Thiazide diuretics and the risk of hip fracture: results from the Framingham Study. JAMA. 1991;265:370-373.
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.