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To the Editor.—Dr Meydani and colleagues1 report interesting data about vitamin E supplementation and in vivo immune response in healthy elderly subjects. One important confounder that was not considered in the study is smoking. Smoking is known to lead to immunosuppression2 - 3 and to increase the requirements for vitamin E.4 Indexes of sustained oxidant stress in smokers are partially ameliorated by vitamin E supplementation.5 Moreover, recent data show that vitamin E may have pro-oxidant activity in nonsmokers at high and prolonged intakes.4 Accordingly, it is relevant for the authors to clarify the number of smokers in each study group.
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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