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December 10, 1997, Vol 278, No. 22 >
ARTICLE | December 10, 1997

Immunohematologic Disorders FREE

Alan Winkelstein, MD; Joseph E. Kiss, MD
JAMA. 1997;278(22):1982-1992. doi:10.1001/jama.1997.03550220188024
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Article
References

Immunohematology encompasses a broad array of clinical disorders in which immune reactions are involved in the pathogenesis of hematologic diseases. Immune reactions can involve the formed elements of the blood, producing hemolytic anemia, thrombocytopenia, or neutropenia. Autoimmune phenomena and drug-induced reactions are the most common mechanisms. In newborns, maternal antibodies can cross the placenta and destroy red blood cells, platelets, or neutrophils. Immune reactions can also occur during transfusion of blood products, leading to hemolysis, febrile reactions, allergic reactions, and lung injury. The role of leukocytes and cytokines released during blood component storage in mediating febrile transfusion reactions has prompted the increased use of leukocyte-reduced components. Immune reactions can occur to soluble clotting factors and can produce bleeding or thrombosis. Finally, immunohematologic features of B-cell disorders are considered.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Frank MM.  Complement: a brief review . J Allergy Clin Immunol . 1989;;84:411-420.
2 +
Judd WJ, Barnes BA, Steiner EA, et al.  The evaluation of a positive direct antiglobulin test (autocontrol) in pretransfusion testing revisited . Transfusion . 1986;;26:220-224.
3 +
Molthan L, Reidenberg MM, Eichman MF.  Positive direct Coombs test due to cephalothifl . N Engl J Med . 1967;;277:123-125.
4 +
Heddle NM, Kelton JG, Turchyn KL, et al.  Hypergammaglobulinemia can be associated with a positive direct antiglobulin test, a nonreactive eluate, and no evidence of hemolysis . Transfusion . 1988;;28:29-33.
5 +
Grindon AJ, Wilson MJ.  False-positive DAT caused by variables in sample procurement . Transfusion . 1981;;21:313-315.
6 +
Hamblin TJ, Oscier TJ, Young BJ, et al.  Autoimmunity in chronic lymphocytic leukaemia . J Clin Pathol . 1986;;39:713-716.
7 +
 Identification of unexpected alloantibodies . In: Walker RH, ed. Technical Manual . Arlington, Va: American Association of Blood Banks; 1990;:293-313.
8 +
Engelfriet CP, Overbeeke MAM, von dem Borne AEG Kr, et al.  Autoimmune hemolytic anemia . Semin Hematol . 1992;;29:3-12.
9 +
Nydegger UE, Kazatchkine MD, Miescher PA, et al.  Immunopathologic and clinical features of hemolytic anemia due to cold agglutinins . Semin Hematol . 1991;;28:66-77.
10 +
Engelfriet CP, Overbeeke MAM, Dooren MC, et al.  Bioassays to determine the clinical significance of red cell alloantibodies based on Fc receptor-induced destruction of red cells sensitized by IgG . Transfusion . 1994;;34:617-626.
11 +
Petz LD, Garratty G. Acquired Immune Hemolytic Anemias . New York, NY: Churchill Livingstone; 1980;.
12 +
Gilliland BC, Baxter E, Evans RS.  Red cell antibodies in acquired hemolytic anemia with negative antiglobulin serum tests . N Engl J Med . 1971;;285:252-256.
13 +
Pirofsky B.  Clinical aspects of autoimmune hemolytic anemia . Semin Hematol . 1976;;13:251-264.
14 +
Flores G, Cunningham-Rundles C, Newland AC, et al.  Efficacy of intravenous immunoglobulin in the treatment of autoimmune hemolytic anemia: results in 73 patients . Am J Hematol . 1993;;44:237-242.
15 +
Ness PM.  Autoimmune hemolytic anemia . In: Brain MC, Carbone PP, ed. Current Therapy in Hematology-Oncology . Philadelphia, Pa: BC Decker; 1992;:25-28.
16 +
Sokol RJ, Booker DJ, Stamps R, et al.  The pathology of autoimmune haemolytic anemia . J Clin Pathol . 1992;;45:1047-1052.
17 +
Pruzanski W, Shumak KH.  Biologic activity of cold-reacting autoantibodies (second of two parts) . N Engl J Med . 1977;;297:583-589.
18 +
Hippe E, Jenson KB, Olesen H, et al.  Chlorambucil treatment of patients with cold agglutinin syndrome . Blood . 1970;;35:68-72.
19 +
Petz LD.  Drug-induced autoimmune hemolytic anemia . Transfus Med Rev . 1993;;7:242-254.
20 +
Garratty G.  Immune cytopenias associated with antibiotics . Transfus Med Rev . 1993;;7:255-267.
21 +
Garratty G, Nance S, Lloyd M, et al.  Fatal immune hemolytic anemia due to cefotetan . Transfusion . 1992;;32:269-271.
22 +
Dhawan M, Kiss JE, DiAddezzio NA, et al.  Fatal cefotetan-induced immune hemolysis . Blood . 1993;;82:582a.
23 +
Bowman JM.  Intrauterine transfusion . In: Anderson KC, Ness PM, eds. Scientific Basis of Transfusion Medicine: Implications for Clinical Practice . Philadelphia, Pa: WB Saunders Co; 1994;; 4:403-420.
24 +
Judd WJ, Luban NLC, Ness PM, et al.  Prenatal and perinatal immunohematology: recommendations for serologic management of the fetus, newborn infant, and obstetric patient . Transfusion . 1990;;30:175-183.
25 +
Chitkara U, Wilkins I, Lynch L, et al.  The role of sonography in assessing the severityof fetal anemia in Rh- and Kell-isoimmunized pregnancies . Obstet Gynecol . 1993;;71:393-398.
26 +
Queenan JT, Tomai TP, Ural SH, et al.  Deviation in amniotic fluid optic density of a wavelength of 450 nm in Rh-immunized pregnancies from 14to40weeks of gestation: a proposal for clinic management . Am J Obstet Gynecol . 1993;;168:1370-1376.
27 +
Fisk NC, Bennett P, Warwick RM, et al.  Clinical utility of fetal RhD typing in alloimmunized pregnancies by means of polymerase chain reaction or aminocytes or chorionic villi . Am J Obstet Gynecol . 1994;;171:50-54.
28 +
Rübo J, Albrecht K, Lasch P, et al.  High-dose intravenous immune globulin therapy for hyperbilirubinemia caused by Rh hemolytic disease . J Pediatr . 1992;;121:93-97.
29 +
Bowman JM.  Antenatal suppression of Rh alloimmunization . Clin Obstet Gynecol . 1991;;34:296-303.
30 +
Bussel JB.  Autoimmune thrombocytopenic purpura . Hematol Oncol Clin North Am . 1990;;4:179-191.
31 +
Waters AH.  Autoimmune thrombocytopenia: clinical aspects . Semin Hematol . 1992;;29:18-25.
32 +
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33 +
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