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Prostate Cancer Transmitted in an Orthotopic Heart Transplant FREE

Harold T. Pretorius, MD, PhD; Peter N. Wurnig, MD
JAMA. 1997;277(17):1355-1355. doi:10.1001/jama.1997.03540410033021
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To the Editor.  —Dr Loh and colleagues1 carefully documented a devastating complication of orthotopic cardiac transplantation: donor-derived transmission of malignancy. It is remarkable that their report of prostate cancer transmission is the only one known, since prostate cancer is the most common malignancy of men in the countries where most transplants are performed.Our interest is not only the medicolegal issues that may arise after organ transplants, but the potential to avoid them. The incidence of melanoma, one of the first tumors reportedly involved in donor transmission of cancer,2 is increasing,3 and it characteristically metastasizes widely throughout the donor's body. Recently, Ciaran et al4 described a very sensitive nuclear scan for melanoma using a radiolabeled benzamide. Such a scan performed on potential organ donors would be likely to detect clinically significant melanoma with potential to metastasize to a transplantable organ.The logistics of transplanting organs, as well summarized by

REFERENCES

Loh E, Couch FJ, Hendricksen C, et al.  Development of donor-derived prostate cancer in a recipient following orthotopic heart transplantation . JAMA . 1997;;277:133-137.
Jeremy D, Farnsworth RH, Robertson MR, Annetts DL, Murnaghan GF.  Transplantation of malignat melanoma with cadaver kidney . Transplantation . 1972;;13:619-620.
Sanderson KV, Mackie R.  Tumors of the skin . In: Rook A, Wilkinson DS, Ebling FJG, eds. Textbook of Dermatology . 3rd ed. Oxford, England: Blackwell Scientific Publication; 1979;;2:2200-2213.
Ciaran N, Ashour M, Hull WE, et al.  Pharmacokinetics of iodine 123—IMBA for melanoma imaging . J Nucl Med . 1997;;38:127-133.
Steinert HC, Huch Boni RA, Buck A, et al.  Malignant melanoma: staging with whole-body positron emission tomography and 2-[F-18]-fluoro-2-deoxy-D-glucose . Radiology . 1995;;195:705-709.
Hoh CK, Hawkins RA, Glaspy JA, et al.  Cancer detection with whole-body PET using 2-[18F]-fluoro-2-deoxy-D-glucose . J Comput Assist Tomogr . 1993;;17:582-589.

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Loh E, Couch FJ, Hendricksen C, et al.  Development of donor-derived prostate cancer in a recipient following orthotopic heart transplantation . JAMA . 1997;;277:133-137.
Jeremy D, Farnsworth RH, Robertson MR, Annetts DL, Murnaghan GF.  Transplantation of malignat melanoma with cadaver kidney . Transplantation . 1972;;13:619-620.
Sanderson KV, Mackie R.  Tumors of the skin . In: Rook A, Wilkinson DS, Ebling FJG, eds. Textbook of Dermatology . 3rd ed. Oxford, England: Blackwell Scientific Publication; 1979;;2:2200-2213.
Ciaran N, Ashour M, Hull WE, et al.  Pharmacokinetics of iodine 123—IMBA for melanoma imaging . J Nucl Med . 1997;;38:127-133.
Steinert HC, Huch Boni RA, Buck A, et al.  Malignant melanoma: staging with whole-body positron emission tomography and 2-[F-18]-fluoro-2-deoxy-D-glucose . Radiology . 1995;;195:705-709.
Hoh CK, Hawkins RA, Glaspy JA, et al.  Cancer detection with whole-body PET using 2-[18F]-fluoro-2-deoxy-D-glucose . J Comput Assist Tomogr . 1993;;17:582-589.
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To understand the clinical management of acute heart failure syndromes.
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