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Genetic Polymorphisms and Breast Cancer Risk FREE

Vahe A. Kazandjian, PhD, MPH
JAMA. 1997;277(7):533-533. doi:10.1001/jama.1997.03540310031027
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To the Editor.  —Western medicine is at a crossroads regarding the understanding of health and disease. Indeed, the discovery of genetic predisposition to diseases previously believed to be primarily "caused" by exposure is changing our appreciation of multifactorialism. Increasingly, biomedical scientists are compelled to learn more about the patient to understand the disease and to appreciate the patient's culture in order to prescribe the acceptable path toward healing the ailment. In short, the discovery of oncogenes may have transformed Western medicine from a disease management doctrine to a social science, perhaps revisiting the nature vs nurture conundrum. And in that transformation medicine may have rediscovered a concept common to many cultures— the concept of destiny.That a person's N-acetyltransferase 2 (NAT2) profile increases susceptibility to breast cancer is a proposition similar to those derived from other potential correlations discovered in the past few years between genetics and incidence of

REFERENCES

Ambrosone CB, Freudenheim JL, Graham S, et al.  Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk . JAMA . 1996;;276:1494-1501.
Correction: JAMA . 1997;;277:534.
Logan RL, Scott PJ.  Uncertainty in clinical practice: implications for quality and costs of health care . Lancet . 1996;;347:595-598.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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Ambrosone CB, Freudenheim JL, Graham S, et al.  Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk . JAMA . 1996;;276:1494-1501.
Correction: JAMA . 1997;;277:534.
Logan RL, Scott PJ.  Uncertainty in clinical practice: implications for quality and costs of health care . Lancet . 1996;;347:595-598.
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