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April 16, 1997, Vol 277, No. 15 >
ARTICLE | April 16, 1997

Thyroid Storm FREE

Drummond Rennie, MD
[+] Author Affiliations

Reprints: Drummond Rennie, MD, JAMA, 515 N State St, Chicago, IL 60610.


JAMA. 1997;277(15):1238-1243. doi:10.1001/jama.1997.03540390068038
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References

In this issue of THE JOURNAL, we are publishing a report1 of work that started 9 years ago, was concluded in December 1990, and the data from which were published in another journal in July 1995. Given that we at JAMA like to keep up-to-date and that we try never to republish what others have already put in print, the reader might well ask what is going on. The story necessary to answer this question provides a cautionary tale that illustrates the sharply differing views of research taken by the university researcher and the company sponsoring that research, if the company's product is at stake. At a time when an increasing proportion of research funding is provided by private companies,2 the story holds lessons for both, as well as for university faculties, administrators, regulatory agencies, and for physicians who prescribe on the basis of evidence.

See also pp

REFERENCES

1 +
Dong BJ, Hauck WW, Gambertoglio JG, Gee L, White JR, Bubp JL, Greenspan FS.  Bioequivalance of generic and brand-name levothyroxine products in the treatment of hypothyroidism . JAMA . 1997;;277:1205-1213.
2 +
Blumenthal D, Causino N, Campbell E, Louis KS.  Relationships between academic institutions and industry in the life sciences: an industry survey . N Engl J Med . 1996;;334:368-373.
3 +
Cooper DS.  Thyroid hormone treatment: new insights into an old therapy . JAMA . 1989;;261:2694-2695.
4 +
King R.  Bitter pill: how a drug company paid for university study, then undermined it . Wall Street Journal . (April 25) , 1996;:1.
5 +
Dong BJ, Young VR, Rapaport B.  The nonequivalence of thyroid products . Drug Intell Clin Pharm . 1986;;20:77-78.
6 +
Benet LZ.  Morality play . Science . 1996;;273:1782.
7 +
University of California Contract and Grant Manual. 1-340 Guidelines on University-Industry Relations, May 17, 1989.
8 +
University of California Contract and Grant Manual. 11-110.
9 +
Kenyon G, Drake S. Statement regarding contract for clinical trials . University of California, San Francisco, February 27, 1996;. Press release.
10 +
Mayor GH, Orlando T, Kurtz NM.  Limitations of levothyroxine bioequivalence evaluation: analysis of an attempted study . Am J Ther . 1995;;2:417-432.
11 +
Berg JA, Mayor GH.  A study in normal human volunteers to compare the rate and extent of levothyroxine absorption from Synthroid and Levoxine . J Clin Pharmacol . 1992;;32:1135-1140.
12 +
Eckert C.  Bioequivalence of levothyroxine preparations: industry sponsorship and academic freedom . JAMA . 1997;;277:1200.
13 +
Spigelman MK.  Bioequivalence of levothyroxine preparations for treatment of hypothyroidism . JAMA . 1997;;277:1199.
14 +
Dong BJ, Hauck WW, Gambertoglio JG, Gee L, White JR, Bubp JL, Greenspan FS.  Bioequivalence of levothyroxine preparations: industry sponsorship and academic freedom . JAMA . 1997;;277:1200-1201.
15 +
Dong BJ, Hauk WW, Gambertoglio JG, Gee L, White JR, Bubp JL, Greenspan FS.  Bioequivalence of levothyroxine preparations for treatment of hypothyroidism . JAMA . 1997;;277:1199-1200.
16 +
Zinberg DS.  A cautionary tale . Science . 1996;;273:411.
17 +
Eckert C.  Morality play . Science . 1996;;273:1784.
18 +
Blumenthal D, Campbell EG, Anderson MS, Causino N, Louis KS.  Withholding research results by academic life scientists: evidence from a national survey of faculty . JAMA . 1997;;277:1224-1228.
19 +
Cohen W, Florida R, Goe WR. University-Industry Research Centers in the United States . Pittsburgh, Pa: Carnegie-Mellon University Press; 1994;.
20 +
Olivieri NF, Brittenham GM, Matsui D, et al.  Iron-chelation therapy with oral deferipronein in patients with thalassemia major . N Engl J Med . 1995;;332:918-922.
21 +
Nathan DG.  An orally active iron chelator . N Engl J Med . 1995;;332:953-954.
22 +
Olivieri NF.  Randomized trial of deferiprone (L1) and deferoxamine (DFO) in thalassemia major . Blood . 1996;;88( (suppl 1) ):651a.
23 +
Jeffrey S.  Research conflict . Med Post . 1997;;33:1.
24 +
Rosenberg SA.  Secrecy in medical research . N Engl J Med . 1996;;334:392-394.
25 +
Rennie D, Flanagin A.  Publication bias: the triumph of hope over experience . JAMA . 1992;;267:411-412.
26 +
Chalmers I.  Underreporting research is scientific misconduct . JAMA . 1990;;263: 1405-1408.
27 +
Marshall E.  Is data-hoarding slowing the assault on pathogens? Science . 1997;;275:777-780.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Dong BJ, Hauck WW, Gambertoglio JG, Gee L, White JR, Bubp JL, Greenspan FS.  Bioequivalance of generic and brand-name levothyroxine products in the treatment of hypothyroidism . JAMA . 1997;;277:1205-1213.
2 +
Blumenthal D, Causino N, Campbell E, Louis KS.  Relationships between academic institutions and industry in the life sciences: an industry survey . N Engl J Med . 1996;;334:368-373.
3 +
Cooper DS.  Thyroid hormone treatment: new insights into an old therapy . JAMA . 1989;;261:2694-2695.
4 +
King R.  Bitter pill: how a drug company paid for university study, then undermined it . Wall Street Journal . (April 25) , 1996;:1.
5 +
Dong BJ, Young VR, Rapaport B.  The nonequivalence of thyroid products . Drug Intell Clin Pharm . 1986;;20:77-78.
6 +
Benet LZ.  Morality play . Science . 1996;;273:1782.
7 +
University of California Contract and Grant Manual. 1-340 Guidelines on University-Industry Relations, May 17, 1989.
8 +
University of California Contract and Grant Manual. 11-110.
9 +
Kenyon G, Drake S. Statement regarding contract for clinical trials . University of California, San Francisco, February 27, 1996;. Press release.
10 +
Mayor GH, Orlando T, Kurtz NM.  Limitations of levothyroxine bioequivalence evaluation: analysis of an attempted study . Am J Ther . 1995;;2:417-432.
11 +
Berg JA, Mayor GH.  A study in normal human volunteers to compare the rate and extent of levothyroxine absorption from Synthroid and Levoxine . J Clin Pharmacol . 1992;;32:1135-1140.
12 +
Eckert C.  Bioequivalence of levothyroxine preparations: industry sponsorship and academic freedom . JAMA . 1997;;277:1200.
13 +
Spigelman MK.  Bioequivalence of levothyroxine preparations for treatment of hypothyroidism . JAMA . 1997;;277:1199.
14 +
Dong BJ, Hauck WW, Gambertoglio JG, Gee L, White JR, Bubp JL, Greenspan FS.  Bioequivalence of levothyroxine preparations: industry sponsorship and academic freedom . JAMA . 1997;;277:1200-1201.
15 +
Dong BJ, Hauk WW, Gambertoglio JG, Gee L, White JR, Bubp JL, Greenspan FS.  Bioequivalence of levothyroxine preparations for treatment of hypothyroidism . JAMA . 1997;;277:1199-1200.
16 +
Zinberg DS.  A cautionary tale . Science . 1996;;273:411.
17 +
Eckert C.  Morality play . Science . 1996;;273:1784.
18 +
Blumenthal D, Campbell EG, Anderson MS, Causino N, Louis KS.  Withholding research results by academic life scientists: evidence from a national survey of faculty . JAMA . 1997;;277:1224-1228.
19 +
Cohen W, Florida R, Goe WR. University-Industry Research Centers in the United States . Pittsburgh, Pa: Carnegie-Mellon University Press; 1994;.
20 +
Olivieri NF, Brittenham GM, Matsui D, et al.  Iron-chelation therapy with oral deferipronein in patients with thalassemia major . N Engl J Med . 1995;;332:918-922.
21 +
Nathan DG.  An orally active iron chelator . N Engl J Med . 1995;;332:953-954.
22 +
Olivieri NF.  Randomized trial of deferiprone (L1) and deferoxamine (DFO) in thalassemia major . Blood . 1996;;88( (suppl 1) ):651a.
23 +
Jeffrey S.  Research conflict . Med Post . 1997;;33:1.
24 +
Rosenberg SA.  Secrecy in medical research . N Engl J Med . 1996;;334:392-394.
25 +
Rennie D, Flanagin A.  Publication bias: the triumph of hope over experience . JAMA . 1992;;267:411-412.
26 +
Chalmers I.  Underreporting research is scientific misconduct . JAMA . 1990;;263: 1405-1408.
27 +
Marshall E.  Is data-hoarding slowing the assault on pathogens? Science . 1997;;275:777-780.

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