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Prenatal Magnesium Sulfate Exposure and Risk of Cerebral Palsy FREE

Elizabeth N. Allred, MD; Olaf Dammann, MD; Karl K. C. Kuban, MS, SM; Alan Leviton, MD, SM; Marcello Pagano, PhD; Jane E. Stewart, MD, SM; Linda J. VanMarter, MD, MPH
[+] Author Affiliations

Edited by Margaret A. Winker, MD, Senior Editor, and Phil B. Fontanarosa, MD, Senior Editor.


JAMA. 1997;277(13):1033-1033. doi:10.1001/jama.1997.03540370023015
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To the Editor.  —The article by Dr Schendel and colleagues1 may have more methodologic limitations than the authors acknowledge. Perhaps the major limitation is the failure to recognize that magnesium might be a marker for other phenomena that contribute to reduced risk of cerebral palsy.During the years study subjects were born (1986-1988), magnesium sulfate was not used as a first-line tocolytic. From 1984 through 1987,31% of the 90 women in one Boston, Mass, hospital who received magnesium sulfate just prior to the birth of a very low-birth-weight infant had a diagnosis of pregnancy-induced hypertension or preeclampsia recorded in the hospital chart,2 similar to the experience in Atlanta, Ga reported by Schendel et al.1 On interview, however, approximately 31% of these women acknowledged that they were told they had either preeclampsia or hypertension.If the situation in Atlanta mimicked what we found in Boston, then receipt of

REFERENCES

Schendel DE, Berg CJ, Yeargin-Alsopp M, Boyle, CA, Decoufle P.  Prenatal magnesium sulfate exposure and the risk for cerebral palsy or mental retardation among very low-birth-weight children aged 3 to 5 years . JAMA . 1996;;276:1805-1810.
Kuban KCK, Leviton A, Pagano M, et al.  Maternal toxemia is associated with reduced incidence of germinal matrix hemorrhage in premature babies . J Child Neurol . 1992;;7:70-76.
Murphy DJ, Sellers S, MacKenzie IZ, Yudkin PL, Johnson AM.  Case-control study of antenatal and intrapartum risk factors for cerebral palsy in very preterm singleton babies . Lancet . 1995;;346:1449-1954.
Grether JK, Nelson KB, Emery ES, Cummins SK.  Prenatal and perinatal factor and cerebral palsy in very low birth weight infants . J Pediatr . 1996;;128:407-414.
Murphy DJ, Johnson A.  Placental infection and risk of cerebral palsy in very low birth weight infants . J Pediatr . 1996;;129:776-777.
Nelson KB, Grether JK.  Can magnesium sulfate reduce the risk of cerebral palsy in very low birthweight infants? Pediatrics . 1995;;263-269.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Schendel DE, Berg CJ, Yeargin-Alsopp M, Boyle, CA, Decoufle P.  Prenatal magnesium sulfate exposure and the risk for cerebral palsy or mental retardation among very low-birth-weight children aged 3 to 5 years . JAMA . 1996;;276:1805-1810.
Kuban KCK, Leviton A, Pagano M, et al.  Maternal toxemia is associated with reduced incidence of germinal matrix hemorrhage in premature babies . J Child Neurol . 1992;;7:70-76.
Murphy DJ, Sellers S, MacKenzie IZ, Yudkin PL, Johnson AM.  Case-control study of antenatal and intrapartum risk factors for cerebral palsy in very preterm singleton babies . Lancet . 1995;;346:1449-1954.
Grether JK, Nelson KB, Emery ES, Cummins SK.  Prenatal and perinatal factor and cerebral palsy in very low birth weight infants . J Pediatr . 1996;;128:407-414.
Murphy DJ, Johnson A.  Placental infection and risk of cerebral palsy in very low birth weight infants . J Pediatr . 1996;;129:776-777.
Nelson KB, Grether JK.  Can magnesium sulfate reduce the risk of cerebral palsy in very low birthweight infants? Pediatrics . 1995;;263-269.
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