Folate and Cardiovascular Disease: Title and subTitle BreakWhy We Need a Trial Now FREE

Meir J. Stampfer, MD, DrPH; Eric B. Rimm, ScD

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Reprints: Meir Stampfer, MD, DrPH, Channing Laboratory, 180 Longwood Ave, Boston, MA 02115.

JAMA. 1996;275(24):1929-1930. doi:10.1001/jama.1996.03530480071044

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ABSTRACT

ABSTRACT | REFERENCES

In this issue of The Journal, Morrison and colleagues¹ provide important new information that fits neatly with the rapidly emerging area of homocysteine, folate, and cardiovascular disease. As comprehensively reviewed last year in JAMA,² strong and remarkably consistent data have linked elevated levels of homocysteine with increased risk of cardiovascular diseases. The risk appears to be graded across the whole distribution of homocysteine levels and, if causal, would account for a substantial fraction of the incidence of these diseases. Elevated homocysteine levels can be reduced by even modest amounts of folate,^3,4 providing a plausible mechanism for the remarkable findings of Morrison et al of a 69% increased risk of coronary mortality among those in the lowest quartile, as compared with highest quartile of serum folate. The findings are similar to previous studies using intermediate end points,⁵ as well as case-control data⁵ and preliminary prospective data

REFERENCES

ABSTRACT | REFERENCES

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal