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June 7, 1995, Vol 273, No. 21 >
ARTICLE | June 7, 1995

Neurology FREE

Robert J. Joynt, MD, PhD
JAMA. 1995;273(21):1695-1697. doi:10.1001/jama.1995.03520450065033
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References

Major advances in the molecular and genetic bases of neurological disease have continued to be the the major focus in the field of neurology. However, notable progress has been made in the prevention, diagnosis, and treatment of neurological disorders. Numerous clinical trials of various drugs and procedures are under way in patients with disorders long resistant to any therapeutic approaches.

The vexing question of whether to operate in cases of asymptomatic internal carotid artery stenosis has been the subject of a large, randomized controlled clinical trial. The interim results of this trial were released in a National Institute of Neurologic Diseases and Stroke Clinical Advisory.1 The conclusion was that carotid endarterectomy is beneficial for patients with asymptomatic carotid stenosis exceeding 60% of diameter reduction as confirmed by arteriography. Results were dependent on medical centers and surgeons who had a perioperative morbidity and mortality rate lower than 3%. Men had

REFERENCES

1 +
National Institute of Neurological Disorders and Stroke Clinical Advisory. Carotid Endarterectomy for Patients With Asymptomatic Internal Carotid Artery Stenosis . Washington, DC: Dept of Health and Human Services; September 28, 1994;:1-3.
2 +
Gorelick PB.  Stroke prevention: an opportunity for efficient utilization of health care resources during the coming decade. Stroke . 1994;;25:220-224.
3 +
Bikkina M, Levy D, Evans JC, et al.  Left ventricular mass and risk of stroke in an elderly cohort: the Framingham Heart Study. JAMA . 1994;;272:33-36.
4 +
Graffagnino C, Herbstreith MH, Roses AD, Alberts MJ.  A molecular genetic study of intracerebral hemorrhage. Arch Neurol . 1994;;51:981-984.
5 +
Gurney ME, Pu H, Chiu AY, et al.  Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science . 1994;;264:1772-1775.
6 +
Takahashi H, Snow BJ, Bhatt MH, Peppard R, Eisen A, Calne DB.  Evidence for a dopaminergic deficit in sporadic amyotrophic lateral sclerosis on positron emission scanning. Lancet . 1993;;342:1016-1018.
7 +
 Report of the Quality Standards Subcommittee of the American Academy of Neurology: practice advisory on selection of patients with multiple sclerosis for treatment with Betaseron. Neurology . 1994;;44:1537-1540.
8 +
Moreau T, Thorpe J, Miller D, et al.  Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis. Lancet. 1994;;344:298-301.
9 +
Sadovnick AD, Eisen K, Hashimoto SA, et al.  Pregnancy and multiple sclerosis. Arch Neurol . 1994;;51:1120-1124.
10 +
van Niekerk ABW, Vries JB, Baard J, Schroub BD, Chezzi C, Blackburn NK.  Outbreak of paralytic poliomyelitis in Namibia. Lancet . 1994;;344:661-664.
11 +
Oostvogel PM, van Wijngaarden JK, van der Avoort HGAM, et al.  Poliomyelitis outbreak in an unvaccinated community in the Netherlands, 1992-93. Lancet . 1994;; 344:665-670.
12 +
Scinto LF, Daffner KR, Dressler D, et al.  A potential noninvasive neurobiological test for Alzheimer's disease. Science . 1994;;266:1051-1054.
13 +
Bush AI, Pettingell WH, Multhaup G, et al.  Rapid induction of Alzheimer AB amyloid formation by zinc. Science . 1994;;265:1464-1467.
14 +
Knapp NJ, Knopman DS, Solomon PR, Pendlebury WW, Davis CS, Gracon SI.  A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. JAMA . 1994;;271:985-991.
15 +
Watkins PB, Zimmerman HJ, Knapp MJ, Cracon SI, Lewis KW.  Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. JAMA . 1994;; 271:992-998.
16 +
Winker MA.  Tacrine for Alzheimer's disease: which patient, what dose? JAMA . 1994;;271:1023-1024.
17 +
Gordon SM, Eaton ME, George R, et al.  The response of symptomatic neurosyphilis to high-dose intravenous penicillin G in patients with human immunodeficiency virus infection. N Engl J Med . 1994;;331:1469-1473.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
National Institute of Neurological Disorders and Stroke Clinical Advisory. Carotid Endarterectomy for Patients With Asymptomatic Internal Carotid Artery Stenosis . Washington, DC: Dept of Health and Human Services; September 28, 1994;:1-3.
2 +
Gorelick PB.  Stroke prevention: an opportunity for efficient utilization of health care resources during the coming decade. Stroke . 1994;;25:220-224.
3 +
Bikkina M, Levy D, Evans JC, et al.  Left ventricular mass and risk of stroke in an elderly cohort: the Framingham Heart Study. JAMA . 1994;;272:33-36.
4 +
Graffagnino C, Herbstreith MH, Roses AD, Alberts MJ.  A molecular genetic study of intracerebral hemorrhage. Arch Neurol . 1994;;51:981-984.
5 +
Gurney ME, Pu H, Chiu AY, et al.  Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science . 1994;;264:1772-1775.
6 +
Takahashi H, Snow BJ, Bhatt MH, Peppard R, Eisen A, Calne DB.  Evidence for a dopaminergic deficit in sporadic amyotrophic lateral sclerosis on positron emission scanning. Lancet . 1993;;342:1016-1018.
7 +
 Report of the Quality Standards Subcommittee of the American Academy of Neurology: practice advisory on selection of patients with multiple sclerosis for treatment with Betaseron. Neurology . 1994;;44:1537-1540.
8 +
Moreau T, Thorpe J, Miller D, et al.  Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis. Lancet. 1994;;344:298-301.
9 +
Sadovnick AD, Eisen K, Hashimoto SA, et al.  Pregnancy and multiple sclerosis. Arch Neurol . 1994;;51:1120-1124.
10 +
van Niekerk ABW, Vries JB, Baard J, Schroub BD, Chezzi C, Blackburn NK.  Outbreak of paralytic poliomyelitis in Namibia. Lancet . 1994;;344:661-664.
11 +
Oostvogel PM, van Wijngaarden JK, van der Avoort HGAM, et al.  Poliomyelitis outbreak in an unvaccinated community in the Netherlands, 1992-93. Lancet . 1994;; 344:665-670.
12 +
Scinto LF, Daffner KR, Dressler D, et al.  A potential noninvasive neurobiological test for Alzheimer's disease. Science . 1994;;266:1051-1054.
13 +
Bush AI, Pettingell WH, Multhaup G, et al.  Rapid induction of Alzheimer AB amyloid formation by zinc. Science . 1994;;265:1464-1467.
14 +
Knapp NJ, Knopman DS, Solomon PR, Pendlebury WW, Davis CS, Gracon SI.  A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. JAMA . 1994;;271:985-991.
15 +
Watkins PB, Zimmerman HJ, Knapp MJ, Cracon SI, Lewis KW.  Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. JAMA . 1994;; 271:992-998.
16 +
Winker MA.  Tacrine for Alzheimer's disease: which patient, what dose? JAMA . 1994;;271:1023-1024.
17 +
Gordon SM, Eaton ME, George R, et al.  The response of symptomatic neurosyphilis to high-dose intravenous penicillin G in patients with human immunodeficiency virus infection. N Engl J Med . 1994;;331:1469-1473.

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