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July 6, 1994, Vol 272, No. 1 >
ARTICLE | July 6, 1994

Left Ventricular Mass and Stroke: Title and subTitle BreakWhat Is The Connection? FREE

Richard B. Devereux, MD
[+] Author Affiliations

Reprint requests to the Division of Cardiology, Box 222, The New York Hospital-Cornell Medical Center, 525 Hospital- 68th St, New York, NY 10021 (Dr Devereux).


JAMA. 1994;272(1):71-72. doi:10.1001/jama.1994.03520010083038
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References

In everyday life, love and other emotions experienced in the brain are often said to come from the heart. In medicine, it is well recognized that the brain can stimulate cardiac arrhythmias and that the heart can serve as a source of emboli to the brain. However, these events are relatively uncommon, and in practice stroke and the major forms of heart disease are usually thought of as quite distinct from each other and best treated by different specialists. This subdivision of care and a combined preventive and therapeutic attack on the atherosclerotic and thrombotic risk factors of smoking, hypertension, and dyslipidemia have led to sustained decreases in cerebrovascular and coronary disease mortality.1 In this issue of THE JOURNAL, however, the article by Bikkina et al2 from the Framingham Heart Study expands the evidence of linkage between diseases of the heart and brain by demonstrating an association between

REFERENCES

1 +
National Heart, Lung, and Blood Institute. Fact Book Fiscal Year 1989 . Washington, DC: US Dept of Health and Human Services; 1989;:29-41.
2 +
Bikkina M, Levy D, Evans JC, et al.  Left ventricular mass and risk of stroke in an elderly cohort: the Framingham Heart Study. JAMA . 1994;;272:33-36.
3 +
Savage DD, Garrison RJ, Kannel WB, Anderson SJ, Feinleib M, Castelli WP.  Considerations in the use of echocardiography in epidemiology: the Framingham Heart Study. Hypertension . 1987;;9( (suppl II) ):1140-1144.
4 +
Levy D, Anderson KM, Savage DD, Kannel WB, Christiansen JC, Castelli WP.  Echocardiographically detected left ventricular hypertrophy: prevalence and risk factors. Ann Intern Med . 1988;;108:7-13.
5 +
Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP.  Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med . 1990;;322:1561-1566.
6 +
de Simone G, Daniels SR, Devereux RB, et al.  Left ventricular mass and body size in normotensive children and adults: assessment of allometric relations and of the impact of overweight. J Am Coll Cardiol . 1992;;20:1251-1260.
7 +
Lauer MS, Anderson KM, Larson MG, Levy D.  A new method for indexing left ventricular mass for differences in body size. Am J Cardiol . In press.
8 +
Devereux RB, Pickering TG, Harshfield GA, et al.  Left ventricular hypertrophy in patients with hypertension: importance of blood pressure response to regularly recurring stress. Circulation . 1983;;68:470-476.
9 +
Lauer MS, Anderson KM, Levy D.  Influence of contemporary versus 30-year blood pressure levels on left ventricular mass and geometry: the Framingham Heart Study. J Am Coll Cardiol . 1991;;18:1287-1294.
10 +
MacMahon S, Peto R, Cutler J, et al.  Blood pressure, stroke, and coronary heart disease—part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet . 1990;;335:765-774.
11 +
Roman MJ, Saba PS, Pini R, et al.  Parallel cardiac and vascular adaptation in hypertension. Circulation . 1992;;86:1909-1918.
12 +
Roman MJ, Spitzer M, Pini R, Pickering T, Devereux RB.  The association of carotid atherosclerosis and increased left ventricular mass in hypertension. J Am Coll Cardiol . 1992;;19:86A.
13 +
Saba PS, Roman MJ, Pini R, Ganau A, Devereux RB.  Relation of carotid pressure waveform to left ventricular anatomy in normotensive subjects. J Am Coll Cardiol . 1993;;22:1873-1880.
14 +
Morgan H, Baker KM.  Cardiac hypertrophy: mechanical, neural, and endocrine dependence. Circulation . 1991;;83:13-25.
15 +
Collins R, Peto R, MacMahon S, et al.  Blood pressure, stroke, and coronary heart disease—part 2, short-term reductions in blood pressure: overview of randomized drug trials in their epidemiological context. Lancet . 1990;;335:827-839.
16 +
Devereux RB, Alderman MH.  Role of preclinical cardiovascular disease in the evolution from risk factor exposure to development of morbid events. Circulation . 1993;;88:1444-1455.
17 +
Koren MJ, Devereux RB, Casale PN, Savage DD, Laragh JH.  Relation of left ventricular mass and geometry to morbidity and mortality in men and women with essential hypertension. Ann Intern Med . 1991;;114:345-352.
18 +
Mensah GA, Pappas TW, Koren MJ, Ulin RJ, Laragh JH, Devereux RB.  Comparison of classification of hypertension severity by blood pressure level and World Health Organization criteria for prediction of concurrent cardiac abnormalities and subsequent complications in essential hypertension. J Hypertens . 1993;;11:1429-1440.
19 +
Ghali JK, Liao Y, Simmons B, Castaner A, Cao G, Cooper RS.  The prognostic role of left ventricular hypertrophy in patients with or without coronary artery disease. Ann Intern Med . 1992;;117:831-836.
20 +
Bolognese L, Dellavessa P, Rossi L, Savasso G, Sante Bongo A, Scianaro M.  Prognostic value of left ventricular mass in uncomplicated acute myocardial infarction and one-vessel coronary artery disease. Am J Cardiol . 1994;;73:1-5.
21 +
Salonen JT, Salonen R.  Ultrasound B-mode imaging in observational studies of atherosclerotic progression. Circulation . 1993;;87( (suppl I) ):I156-I165.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
National Heart, Lung, and Blood Institute. Fact Book Fiscal Year 1989 . Washington, DC: US Dept of Health and Human Services; 1989;:29-41.
2 +
Bikkina M, Levy D, Evans JC, et al.  Left ventricular mass and risk of stroke in an elderly cohort: the Framingham Heart Study. JAMA . 1994;;272:33-36.
3 +
Savage DD, Garrison RJ, Kannel WB, Anderson SJ, Feinleib M, Castelli WP.  Considerations in the use of echocardiography in epidemiology: the Framingham Heart Study. Hypertension . 1987;;9( (suppl II) ):1140-1144.
4 +
Levy D, Anderson KM, Savage DD, Kannel WB, Christiansen JC, Castelli WP.  Echocardiographically detected left ventricular hypertrophy: prevalence and risk factors. Ann Intern Med . 1988;;108:7-13.
5 +
Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP.  Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med . 1990;;322:1561-1566.
6 +
de Simone G, Daniels SR, Devereux RB, et al.  Left ventricular mass and body size in normotensive children and adults: assessment of allometric relations and of the impact of overweight. J Am Coll Cardiol . 1992;;20:1251-1260.
7 +
Lauer MS, Anderson KM, Larson MG, Levy D.  A new method for indexing left ventricular mass for differences in body size. Am J Cardiol . In press.
8 +
Devereux RB, Pickering TG, Harshfield GA, et al.  Left ventricular hypertrophy in patients with hypertension: importance of blood pressure response to regularly recurring stress. Circulation . 1983;;68:470-476.
9 +
Lauer MS, Anderson KM, Levy D.  Influence of contemporary versus 30-year blood pressure levels on left ventricular mass and geometry: the Framingham Heart Study. J Am Coll Cardiol . 1991;;18:1287-1294.
10 +
MacMahon S, Peto R, Cutler J, et al.  Blood pressure, stroke, and coronary heart disease—part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet . 1990;;335:765-774.
11 +
Roman MJ, Saba PS, Pini R, et al.  Parallel cardiac and vascular adaptation in hypertension. Circulation . 1992;;86:1909-1918.
12 +
Roman MJ, Spitzer M, Pini R, Pickering T, Devereux RB.  The association of carotid atherosclerosis and increased left ventricular mass in hypertension. J Am Coll Cardiol . 1992;;19:86A.
13 +
Saba PS, Roman MJ, Pini R, Ganau A, Devereux RB.  Relation of carotid pressure waveform to left ventricular anatomy in normotensive subjects. J Am Coll Cardiol . 1993;;22:1873-1880.
14 +
Morgan H, Baker KM.  Cardiac hypertrophy: mechanical, neural, and endocrine dependence. Circulation . 1991;;83:13-25.
15 +
Collins R, Peto R, MacMahon S, et al.  Blood pressure, stroke, and coronary heart disease—part 2, short-term reductions in blood pressure: overview of randomized drug trials in their epidemiological context. Lancet . 1990;;335:827-839.
16 +
Devereux RB, Alderman MH.  Role of preclinical cardiovascular disease in the evolution from risk factor exposure to development of morbid events. Circulation . 1993;;88:1444-1455.
17 +
Koren MJ, Devereux RB, Casale PN, Savage DD, Laragh JH.  Relation of left ventricular mass and geometry to morbidity and mortality in men and women with essential hypertension. Ann Intern Med . 1991;;114:345-352.
18 +
Mensah GA, Pappas TW, Koren MJ, Ulin RJ, Laragh JH, Devereux RB.  Comparison of classification of hypertension severity by blood pressure level and World Health Organization criteria for prediction of concurrent cardiac abnormalities and subsequent complications in essential hypertension. J Hypertens . 1993;;11:1429-1440.
19 +
Ghali JK, Liao Y, Simmons B, Castaner A, Cao G, Cooper RS.  The prognostic role of left ventricular hypertrophy in patients with or without coronary artery disease. Ann Intern Med . 1992;;117:831-836.
20 +
Bolognese L, Dellavessa P, Rossi L, Savasso G, Sante Bongo A, Scianaro M.  Prognostic value of left ventricular mass in uncomplicated acute myocardial infarction and one-vessel coronary artery disease. Am J Cardiol . 1994;;73:1-5.
21 +
Salonen JT, Salonen R.  Ultrasound B-mode imaging in observational studies of atherosclerotic progression. Circulation . 1993;;87( (suppl I) ):I156-I165.

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