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Antimicrobial Therapy for Otitis Media With Effusion: The Pittsburgh Response-Reply FREE

Ellen M. Mandel, MD; Howard E. Rockette, PhD; Charles D. Bluestone, MD; Jack L. Paradise, MD; Robert J. Nozza, PhD
JAMA. 1993;270(4):450-450. doi:10.1001/jama.1993.03510040053017
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In Reply.  —Dr Cantekin has responded to virtually none of the substance of our article, but instead advances invalid accusations and other misleading statements.First, as for "special oversight," the OSI noted that "the recommendations concerning operations of the OMRC were not intended as sanctions..." but "were intended to provide safeguards against even the appearance of possible conflict of interest..."1(p3) The OSI did not find that Dr Bluestone had "financial ties to drug companies." Dr Bluestone had received research support from drug companies and honoraria for presentations at scientific and educational meetings, but the OSI did not find that these funds were "undisclosed." The OSI also did not find "bias."2Second, the OSI commentary on antibiotic therapy now cited by Cantekin referred not to our New England Journal of Medicine article3 that Cantekin and his coauthors had criticized4 and that our JAMA article defended, but rather

REFERENCES

Office of Scientific Integrity Inquiry Report: Covering Clinical Trials for Otitis Media Conducted at the Children's Hospital of Pittsburgh . Washington, DC: US Dept of Health and Human Services; 1990;.
Office of Scientific Integrity Inquiry Report: Covering Clinical Trials for Otitis Media Conducted at the Children's Hospital of Pittsburgh. Response to Comments on the Draft Inquiry Report (Appendix) . Washington DC: US Dept of Health and Human Services; 1990;.
Mandel EM, Rockette HE, Bluestone CD, Paradise IL, Nozza RJ.  Efficacy of amoxicillin with and without decongestant-antihistamine for otitis media with effusion in children. N Engl J Med . 1987;;316:432-437.
Cantekin EI, McGuire TM, Griffith TL.  Antimicrobial therapy for otitis media with effusion ('secretory' otitis media). JAMA . 1991;;266:3309-3317.
Mandel EM, Rockette HE, Paradise IL, Bluestone CD, Nozza RJ.  Comparative efficacy of erythromycin-sulfisoxazole, cefaclor, amoxicillin or placebo for otitis media with effusion in children. Pediatr Infect Dis J . 1991;;10:899-906.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Office of Scientific Integrity Inquiry Report: Covering Clinical Trials for Otitis Media Conducted at the Children's Hospital of Pittsburgh . Washington, DC: US Dept of Health and Human Services; 1990;.
Office of Scientific Integrity Inquiry Report: Covering Clinical Trials for Otitis Media Conducted at the Children's Hospital of Pittsburgh. Response to Comments on the Draft Inquiry Report (Appendix) . Washington DC: US Dept of Health and Human Services; 1990;.
Mandel EM, Rockette HE, Bluestone CD, Paradise IL, Nozza RJ.  Efficacy of amoxicillin with and without decongestant-antihistamine for otitis media with effusion in children. N Engl J Med . 1987;;316:432-437.
Cantekin EI, McGuire TM, Griffith TL.  Antimicrobial therapy for otitis media with effusion ('secretory' otitis media). JAMA . 1991;;266:3309-3317.
Mandel EM, Rockette HE, Paradise IL, Bluestone CD, Nozza RJ.  Comparative efficacy of erythromycin-sulfisoxazole, cefaclor, amoxicillin or placebo for otitis media with effusion in children. Pediatr Infect Dis J . 1991;;10:899-906.
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