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ARTICLE |

Antimicrobial Therapy for Otitis Media With Effusion: The Pittsburgh Response FREE

Erdem I. Cantekin, PhD
[+] Author Affiliations

Edited by Drummond Rennie, MD, Deputy Editor (West), and Margaret A. Winker, MD, Senior Editor.


JAMA. 1993;270(4):449-449. doi:10.1001/jama.1993.03510040053015
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To the Editor.  —The article by Mandel et al1 is troubling because it contains the same serious scientific lapses and factual errors that were in an earlier full-length manuscript that I reviewed for JAMA. The accusations of Mandel et al that I have manipulated data, misanalyzed data, engaged in a post hoc alteration of outcome determinations, and engaged in fallacious reasoning are impossible to dispatch in this short space. Last year I provided JAMA with a detailed analysis and refutation of each (written communication, review of manuscript CO2056, May 1992).The National Institutes of Health, based on its Office of Scientific Integrity (OSI) report, placed Charles D. Bluestone, MD, the principal investigator of the Otitis Media Research Center, on a 5-year special oversight to ensure against real or apparent conflicts of interest because of his undisclosed substantial financial ties to drug companies and his bias in reporting antibiotic efficacy

REFERENCES

Mandel EM, Rockette HE, Bluestone CD, Paradise JL, Nozza RJ.  Antibiotic therapy for otitis media with effusion: a response from Pittsburgh. JAMA . 1993;; 269:516-517.
Office of Scientific Integrity Inquiry Report: Covering Clinical Trials for Otitis Media Conducted at the Children's Hospital of Pittsburgh . Washington, DC: US Dept of Health and Human Services; December 1990;.
Mandel EM, Rockette HE, Bluestone CD, Paradise IL, Nozza RJ.  Efficacy of amoxicillin with and without decongestant-antihistamine for otitis media with effusion in children. N Engl J Med . 1987;;316:432-437.
Cantekin EI, McGuire TM, Griffith TL.  Antimicrobial therapy for otitis media with effusion ('secretory' otitis media). JAMA . 1991;;266:3309-3317.
Mandel EM, Rockette HE, Paradise IL, Bluestone CD, Nozza RJ.  Comparative efficacy of erythromycin-sulfisoxazole, cefaclor, amoxicillin or placebo for otitis media with effusion in children. Pediatr Infect Dis J . 1991;;10:899-906.
Froom J, Culpepper L, Grob P, et al.  Diagnosis and antibiotic treatment of acute otitis media: report from International Primary Care Network. BMJ . 1990;;300:1005-1007.
Appelman CLM, Claessen JQPJ, Touw-Otten FWMM, Hordijk GJ, de Melker RA.  Co-amoxiclav in recurrent acute otitis media: placebo controlled study. BMJ . 1991;; 303:1450-1452.
Claessen JQPJ, Appelman CLM, Touw-Otten FWMM, de Melker RA, Hordijk GJ.  A review of clinical trials regarding treatment of acute otitis media. Clin Otolaryngol . 1992;;17:251-257.

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Mandel EM, Rockette HE, Bluestone CD, Paradise JL, Nozza RJ.  Antibiotic therapy for otitis media with effusion: a response from Pittsburgh. JAMA . 1993;; 269:516-517.
Office of Scientific Integrity Inquiry Report: Covering Clinical Trials for Otitis Media Conducted at the Children's Hospital of Pittsburgh . Washington, DC: US Dept of Health and Human Services; December 1990;.
Mandel EM, Rockette HE, Bluestone CD, Paradise IL, Nozza RJ.  Efficacy of amoxicillin with and without decongestant-antihistamine for otitis media with effusion in children. N Engl J Med . 1987;;316:432-437.
Cantekin EI, McGuire TM, Griffith TL.  Antimicrobial therapy for otitis media with effusion ('secretory' otitis media). JAMA . 1991;;266:3309-3317.
Mandel EM, Rockette HE, Paradise IL, Bluestone CD, Nozza RJ.  Comparative efficacy of erythromycin-sulfisoxazole, cefaclor, amoxicillin or placebo for otitis media with effusion in children. Pediatr Infect Dis J . 1991;;10:899-906.
Froom J, Culpepper L, Grob P, et al.  Diagnosis and antibiotic treatment of acute otitis media: report from International Primary Care Network. BMJ . 1990;;300:1005-1007.
Appelman CLM, Claessen JQPJ, Touw-Otten FWMM, Hordijk GJ, de Melker RA.  Co-amoxiclav in recurrent acute otitis media: placebo controlled study. BMJ . 1991;; 303:1450-1452.
Claessen JQPJ, Appelman CLM, Touw-Otten FWMM, de Melker RA, Hordijk GJ.  A review of clinical trials regarding treatment of acute otitis media. Clin Otolaryngol . 1992;;17:251-257.
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