Edited by Drummond Rennie, MD, Deputy Editor (West), and Margaret A. Winker, MD, Senior Editor.
To the Editor. —The Treatment of Mild Hypertension Study (TOMHS)1 represents a worthy contribution to the evaluation of therapeutic interventions on outcomes in patients with mild hypertension. The use of broad categories of morbidity and mortality outcomes demonstrated the overall benefit of antihypertensive agents plus lifestyle modification compared with lifestyle modification alone. Blood pressure reductions with all five antihypertensive agents (acebutolol, amlodipine maleate, chlorthalidone, doxazosin mesylate, and enalapril maleate) plus lifestyle modification were significantly greater than with lifestyle modification alone for "all follow-up BP [blood pressure] measurements."The significance of blood pressure reduction was also addressed in the accompanying Editorial2 stating, "All classes of drugs, with the exception of the angiotensin-converting enzyme inhibitor (enalapril), were equally effective in lowering blood pressure in TOMHS and all were superior to the lifestyle-modification regimen given with placebo." Clarification of this statement is needed because the drug dosages evaluated in TOMHS were
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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