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Urology FREE

William J. Catalona, MD
JAMA. 1993;270(2):265-266. doi:10.1001/jama.1993.03510020133048
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Recent research results have produced new developments in the areas of prostate cancer and benign prostatic hyperplasia.

The American Cancer Society1 and the American Urological Association2 now recommend annual prostate-specific antigen (PSA) level testing and rectal examinations beginning at the age of 50 years for the early detection of prostate cancer, and beginning at the age of 40 years for high-risk men such as African Americans and those with a strong family history of prostate cancer. An upper age limit has not been set, but routine screening is not desirable in men with a life expectancy of less than 10 years. Annual examinations may be especially important in men who have had a vasectomy, who may have an increased risk of prostate cancer.3 Serial PSA level measurements over an extended period identify men with prostate cancer years before the disease becomes clinically manifest,4 and generally detect

REFERENCES

Mettlin C, Jones G, Averette H, Gusberg SB, Murphy GP.  Defining and updating the American Cancer Society guidelines for cancer-related checkup: prostate and endometrial cancer. CA Cancer J Clin . 1993;;43:42-46.
American Urological Association.  Early detection of prostate cancer and use of transrectal ultrasound.  In: American Urological Association 1992 Policy Statement Book . Baltimore, Md: American Urological Association; 1992;:420.
Giovannucci E, Ascherio A, Rimm EB, Colditz GA, Stampfer MJ, Willett WC.  A prospective cohort study of vasectomy and prostate cancer in US men. JAMA . 1993;;269:873-877.
Carter HB, Pearson JO, Metter J, et al.  Longitudinal evaluation of prostate-specific antigen levels in men with and without prostate disease. JAMA . 1992;;267:2215-2220.
Catalona WJ, Smith DS, Ratliff TL, et al.  Measurement of prostate-specific antigen in serum as a screening test for prostate cancer. N Engl J Med . 1991;;324:1156-1161.
Catalona WJ, Smith DS, Ratliff TL.  Single and serial measurement of serum prostate specific antigen as a screening test for early prostate cancer. J Urol . April 1992;;147( (suppl) ):450.
Brawn PN, Speights VO, Kuhl D, et al.  Prostate-specific antigen levels from completely sectioned, clinically benign, whole prostates. Cancer . 1991;;68:1592-1599.
Stormont TJ, Farrow GM, Myers RP, et al.  Clinical stage B0 or Tic prostate cancer: non-palpable disease identified by an elevated serum prostate specific antigen concentration. Urology . 1993;;41: 3-8.
Gerber GS, Thompson IM, Thisted R, Chodak GW.  Disease-specific survival following routine prostate cancer screening by digital rectal examination. JAMA . 1993;;269:61-64.
Johansson J-E, Adami H-O, Andersson S-O, Bergström R, Holmberg L, Krusemo UB.  High 10-year survival rate in patients with early, untreated prostatic cancer. JAMA . 1992;;267:2191-2196.
Simpson KN, Brown RE.  Cost-effectiveness of adding prostate specific antigen (PSA) test to digital rectal examination (DRE) for early detection of prostate cancer. J Urol . 1993;;149:413A.
Pollard M, Luckert PH, Sporn MB.  Prevention of primary prostate cancer in Lobund-Wistar rats by N-(4-hydroxyphenyl) retinamide. Cancer Res . 1991;;51:3610-3611.
Gormley GJ.  Chemoprevention strategies for prostate cancer: the role of 5 alpha-reductase inhibitors. J Cell Biochem Suppl . 1992;;16H:113-117.
Presti JC Jr, Fair WR, Andriole GL et al.  Multicenter, randomized double-blind, placebo controlled study to investigate the effect of finasteride (MK-906) on stage D prostate cancer. J Urol . 1992;;148:1201-1204.
Bosland MC.  Possible enhancement of prostate carcinogenesis by some chemopreventive agents. J Cell Biochem Suppl . 1992;;16H: 135-137.
Lepor H, Auerbach S, Puras-Baez A, et al.  A randomized, placebo-controlled multicenter study of the efficacy and safety of terazosin in the treatment of benign prostatic hyperplasia. J Urol . 1992;;148:1467-1474.
Gormley GJ, Stoner E, Bruskewitz RC, et al.  The effect of finasteride in men with benign prostatic hyperplasia. N Engl J Med . 1992;;327:1185-1191.
Barry MJ, Fowler FJ Jr, O'Leary MP, et al.  The American Urological Association symptom index for benign prostatic hyperplasia. J Urol . 1992;;148:1549-1557.
Geller DM.  Finasteride for benign prostatic hyperplasia (letter to the editor and the authors reply). N Engl J Med . 1993;;328:442-443.
Lange PH.  Is the prostate pill finally here? New Engl J Med . 1992;;327:1234-1236.
Pollard M.  The Lobund-Wistar rat model of prostate cancer. J Cell Biochem Suppl . 1992;;16H:84-88.

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Mettlin C, Jones G, Averette H, Gusberg SB, Murphy GP.  Defining and updating the American Cancer Society guidelines for cancer-related checkup: prostate and endometrial cancer. CA Cancer J Clin . 1993;;43:42-46.
American Urological Association.  Early detection of prostate cancer and use of transrectal ultrasound.  In: American Urological Association 1992 Policy Statement Book . Baltimore, Md: American Urological Association; 1992;:420.
Giovannucci E, Ascherio A, Rimm EB, Colditz GA, Stampfer MJ, Willett WC.  A prospective cohort study of vasectomy and prostate cancer in US men. JAMA . 1993;;269:873-877.
Carter HB, Pearson JO, Metter J, et al.  Longitudinal evaluation of prostate-specific antigen levels in men with and without prostate disease. JAMA . 1992;;267:2215-2220.
Catalona WJ, Smith DS, Ratliff TL, et al.  Measurement of prostate-specific antigen in serum as a screening test for prostate cancer. N Engl J Med . 1991;;324:1156-1161.
Catalona WJ, Smith DS, Ratliff TL.  Single and serial measurement of serum prostate specific antigen as a screening test for early prostate cancer. J Urol . April 1992;;147( (suppl) ):450.
Brawn PN, Speights VO, Kuhl D, et al.  Prostate-specific antigen levels from completely sectioned, clinically benign, whole prostates. Cancer . 1991;;68:1592-1599.
Stormont TJ, Farrow GM, Myers RP, et al.  Clinical stage B0 or Tic prostate cancer: non-palpable disease identified by an elevated serum prostate specific antigen concentration. Urology . 1993;;41: 3-8.
Gerber GS, Thompson IM, Thisted R, Chodak GW.  Disease-specific survival following routine prostate cancer screening by digital rectal examination. JAMA . 1993;;269:61-64.
Johansson J-E, Adami H-O, Andersson S-O, Bergström R, Holmberg L, Krusemo UB.  High 10-year survival rate in patients with early, untreated prostatic cancer. JAMA . 1992;;267:2191-2196.
Simpson KN, Brown RE.  Cost-effectiveness of adding prostate specific antigen (PSA) test to digital rectal examination (DRE) for early detection of prostate cancer. J Urol . 1993;;149:413A.
Pollard M, Luckert PH, Sporn MB.  Prevention of primary prostate cancer in Lobund-Wistar rats by N-(4-hydroxyphenyl) retinamide. Cancer Res . 1991;;51:3610-3611.
Gormley GJ.  Chemoprevention strategies for prostate cancer: the role of 5 alpha-reductase inhibitors. J Cell Biochem Suppl . 1992;;16H:113-117.
Presti JC Jr, Fair WR, Andriole GL et al.  Multicenter, randomized double-blind, placebo controlled study to investigate the effect of finasteride (MK-906) on stage D prostate cancer. J Urol . 1992;;148:1201-1204.
Bosland MC.  Possible enhancement of prostate carcinogenesis by some chemopreventive agents. J Cell Biochem Suppl . 1992;;16H: 135-137.
Lepor H, Auerbach S, Puras-Baez A, et al.  A randomized, placebo-controlled multicenter study of the efficacy and safety of terazosin in the treatment of benign prostatic hyperplasia. J Urol . 1992;;148:1467-1474.
Gormley GJ, Stoner E, Bruskewitz RC, et al.  The effect of finasteride in men with benign prostatic hyperplasia. N Engl J Med . 1992;;327:1185-1191.
Barry MJ, Fowler FJ Jr, O'Leary MP, et al.  The American Urological Association symptom index for benign prostatic hyperplasia. J Urol . 1992;;148:1549-1557.
Geller DM.  Finasteride for benign prostatic hyperplasia (letter to the editor and the authors reply). N Engl J Med . 1993;;328:442-443.
Lange PH.  Is the prostate pill finally here? New Engl J Med . 1992;;327:1234-1236.
Pollard M.  The Lobund-Wistar rat model of prostate cancer. J Cell Biochem Suppl . 1992;;16H:84-88.
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