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Effect of Magnesium on Postoperative Dysrhythmias-Reply FREE

Michael R. England, MD; George Gordon, MD; Michael Salem, MD; Bart Chernow, MD
JAMA. 1993;269(18):2370-2370. doi:10.1001/jama.1993.03500180061034
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In Reply.  —appreciate the opportunity to clarify the issues raised regarding our placebo-controlled, randomized trial of magnesium administration in cardiac surgery patients. Two other recent studies in cardiac surgery patients1-2 and another randomized trial3 of magnesium administration in patients with suspected acute myocardial infarction support the hypothesis that magnesium administration decreases morbidity and mortality in patients with ischemic cardiovascular disease.Regarding matching of treatment groups, Table 3 in our study accurately indicates that the treatment and placebo groups were matched with respect to the performance of coronary bypass grafting and/or valve replacement procedures. There were no significant differences between treatment groups in terms of the four patients who had electrode patches placed, an implantable defibrillator device placed, or a left ventricular aneurysm resection (in addition to coronary artery bypass grafting and/or valve replacement). Continuous electrocardiographic techniques were used to identify clinically important dysrhythmias while patients were

REFERENCES

Schwieger I, Kopel ME, Finlayson DC.  Magnesium reduces the incidence of postoperative dysrhythmias in patients after cardiac surgery. Anesthesiology . 1989;;71: Al 162. Abstract.
Fanning WJ, Thomas CS, Roach A, Tomichek R, Alford WC, Stoney WS.  Prophylaxis of atrial fibrillation with magnesium sulfate after coronary artery bypass grafting. Ann Thorac Surg . 1991;;52:529-533.
Woods KL, Fletcher S, Roffe C, Haider Y.  Intravenous magnesium sulphate in suspected acute myocardial infarction: results of the second Leicester intravenous magnesium intervention trial (LIMIT-2). Lancet . 1992;;339:1553-1558.
Aglio LS, Stanford GG, Maddi R, Boyd JL, Nussbaum S, Chernow B.  Hypomagnesemia is common following cardiac surgery. J Cardiothorac Anes . 1991;;5:201-208.

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Schwieger I, Kopel ME, Finlayson DC.  Magnesium reduces the incidence of postoperative dysrhythmias in patients after cardiac surgery. Anesthesiology . 1989;;71: Al 162. Abstract.
Fanning WJ, Thomas CS, Roach A, Tomichek R, Alford WC, Stoney WS.  Prophylaxis of atrial fibrillation with magnesium sulfate after coronary artery bypass grafting. Ann Thorac Surg . 1991;;52:529-533.
Woods KL, Fletcher S, Roffe C, Haider Y.  Intravenous magnesium sulphate in suspected acute myocardial infarction: results of the second Leicester intravenous magnesium intervention trial (LIMIT-2). Lancet . 1992;;339:1553-1558.
Aglio LS, Stanford GG, Maddi R, Boyd JL, Nussbaum S, Chernow B.  Hypomagnesemia is common following cardiac surgery. J Cardiothorac Anes . 1991;;5:201-208.
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To understand the clinical management of acute heart failure syndromes.
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