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ARTICLE |

Diuretics, Potassium, and Ventricular Arrhythmias FREE

A. Mark Clarfield, MD; Ruby Friedman, MD; Howard Bergman, MD
JAMA. 1992;268(1):52-52. doi:10.1001/jama.1992.03490010054020
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To the Editor.  —It is now abundantly clear that hypertension is a problem for both young and old. In fact, one can argue that it is an even more serious condition for the elderly, given that the sequelae of hypertension are found mostly in those over the age of 65.1JAMA, as well as other medical journals, has recognized the importance of hypertension in the elderly and published numerous articles on this subject over the past few years. The Systolic Hypertension in the Elderly Program study2 is only one recent example.Thus, it is with surprise and some consternation that we examined the recent article by Siegel et al3 on diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men. This was a first-class piece of research. For some reason, however, the sample population was restricted to patients under the age of 70.The exclusion

REFERENCES

Applegate WB.  Hypertension in elderly patients. Ann Intern Med . 1989;;110:901-915.
SHEP Cooperative Research Group.  Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA . 1991;;265:3255-3264.
Siegel D, Hulley SB, Black DM, et al.  Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men. JAMA . 1992;;267:1083-1089.
Healy B.  The Yentl syndrome. N Engl J Med . 1991;;325:274-276.
Clarfield AM, Friedman R.  Survey of the age structure of 'age relevant' articles in four medical journals. J Am Geriatr Soc . 1985;;33:773-778.
Kilner JF.  Age criteria in medicine: are the medical justifications ethical? Arch Intern Med . 1989;;149:2343-6.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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Applegate WB.  Hypertension in elderly patients. Ann Intern Med . 1989;;110:901-915.
SHEP Cooperative Research Group.  Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA . 1991;;265:3255-3264.
Siegel D, Hulley SB, Black DM, et al.  Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men. JAMA . 1992;;267:1083-1089.
Healy B.  The Yentl syndrome. N Engl J Med . 1991;;325:274-276.
Clarfield AM, Friedman R.  Survey of the age structure of 'age relevant' articles in four medical journals. J Am Geriatr Soc . 1985;;33:773-778.
Kilner JF.  Age criteria in medicine: are the medical justifications ethical? Arch Intern Med . 1989;;149:2343-6.
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