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Trends in Mortality, Morbidity, and Risk Factor Levels for Stroke From 1960 Through 1990: Title and subTitle BreakThe Minnesota Heart Survey FREE

Paul G. McGovern, PhD; Gregory L. Burke, MD; J. Michael Sprafka, PhD; Songlin Xue, PhD, MPH; Aaron R. Folsom, MD; Henry Blackburn, MD
[+] Author Affiliations

Reprint requests to Division of Epidemiology, School of Public Health, University of Minnesota, 1300 S 2nd St, Suite 300, Minneapolis, MN 55454-1015 (Dr McGovern).


JAMA. 1992;268(6):753-759. doi:10.1001/jama.1992.03490060085029
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Objective.  —The Minnesota Heart Survey is a population-based study designed to monitor and explain trends in cardiovascular mortality, morbidity, and risk factors.

Design.  —Surveillance time-trends study.

Methods.  —The following trends were examined among men and women aged 25 to 74 years living in Minneapolis—St Paul, Minn: (1) stroke mortality from 1960 through 1990; (2) risk factors in population-based surveys conducted in 1973 through 1974, 1980 through 1982, and 1985 through 1987; and (3) morbidity in a 50% sample of hospitalized discharges for acute-stroke in 1970, 1980, and 1985.

Results.  —Stroke mortality in Minneapolis—St Paul declined slowly from 1960 through 1972 (average fall, 2.4% per year), dropped sharply from 1972 through 1984 (average fall, 6.5% per year), but exhibited little change thereafter (average fall, 1.5% per year). The average level of cardiovascular disease risk factors fell from 1973-1974 to 1985-1987, with the exception of body mass index. In particular, hypertension diagnosis, treatment, and control levels improved substantially between 1973-1974 and 1980-1982, although there was little improvement after 1980-1982. While discharge rates for hospital-coded acute stroke declined substantially between 1970 and 1985 in both sexes, no clear trend was observed in definite stroke rates as validated using standard clinical criteria. Twenty-eight—day case fatality rates of definite stroke improved significantly from 1970 to 1985.

Conclusions.  —The substantial decline in stroke mortality of more than 50% from 1960 through 1990 appears to have been attributable to both primary and secondary prevention. These data suggest that the long decline in stroke mortality and morbidity in Minneapolis—St Paul has plateaued, although improved detection of stroke with computed tomography prevents an unequivocal conclusion.(JAMA. 1992;268:753-759)

REFERENCES

National Center for Health Statistics.  Advance report of final mortality statistics, 1986. Monthly Vital Stat Rep . 1992;;40( (suppl 2) ):1-55.
Dawson DA, Adams PF.  Current estimates from the National Center for Health Statistics. Vital Health Stat . 1987;;10:164.
WhisnantJP.  The decline of stroke. Stroke . 1984;; 15:160-168.
Gillum RF, Gomez-Marin 0, Kottke TE, et al.  Acute stroke in a metropolitan area, 1970 and 1980: the Minnesota Heart Survey. J Chronic Dis . 1985;; 38:8911-8918.
Folsom AR, Luepker RV, Gillum RF, et al.  Improvement of hypertension detection and control from 1973-1974 to 1981-1982: the Minnesota Heart Survey experience. JAMA . 1983;;250:916-921.
Luepker RV, Jacobs DR, Folsom AR, et al.  Cardiovascular risk factors—1973-74 to 1980-82: the Minnesota Heart Survey. J Clin Epidemiol . 1988;; 41:825-833.
World Health Organization. Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death, Based on the Recommendations of the Seventh Revision Conference, 1955 . Geneva, Switzerland: World Health Organization; 1957;.
World Health Organization. Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death, Based on the Recommendations of the Eighth Revision Conference, 1965 . Geneva, Switzerland: World Health Organization; 1967;.
World Health Organization. Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death, Based on the Recommendations of the Ninth Revision Conference, 1975 . Geneva, Switzerland: World Health Organization; 1977;.
National Center for Health Statistics. Comparability of mortality statistics for the seventh and eighth revisions of the International Classification of Diseases, United States . Rockville, Md: Dept of Health, Education, and Welfare; 1975;:66. Series 2.
National Center for Health Statistics.  Estimates of selected comparability ratios based on dual coding of 1976 death certificates by the eighth and ninth revisions of the International Classification of Diseases. Monthly Vital Stat Rep . 1980;;28( (suppl) ): 1-18.
Jacobs DRJr, Hunninghake DB, Dempsey ME, et al.  Blood lipids and lipoproteins in a Minnesota urban population. J Chronic Dis . 1980;;33:395-406.
Sprafka JM, Burke GL, Folsom AR, Luepker RV, Blackburn H.  Continued decline in cardiovascular disease risk factors: results from the Minnesota Heart Survey, 1980-82 to 1985-87. Am J Epidemiol . 1990;;132:489-500.
Jeffery RW, Folsom AR, Luepker RV, et al.  Prevalence of overweight and weight loss behavior in a metropolitan adult population: the Minnesota Heart Survey experience. Am J Public Health . 1984;;74:349-352.
SAS Institute Inc. SAS/STAT Guide . Version 6, 4th ed. Cary, NC: Statistical Analysis Systems Institute Inc; 1989;(1,2).
Edlavitch SA, Baxter J.  Comparability of mortality follow-up before and after the National Death Index. Am J Epidemiol . 1988;;127:1164-1178.
World Health Organization. World Health Statistics Annual . Geneva, Switzerland: World Health Organization; 1990;.
Gillum RF.  Cerebrovascular disease morbidity in the United States, 1970-1983: age, sex, region, and vascular surgery. Stroke . 1986;;17:656-661.
Centers for Disease Control.  Hospital discharge rates for cerebrovascular disease: United States, 1970-1986. MMWR . 1989;;38:194-201.
Broderick JP, Phillips SJ, Whisnant JP, O'Fallon WM, Bergstralh EJ.  Incidence rates of stroke in the eighties: the end of the decline in stroke? Stroke . 1989;;20:577-582.
Graves EJ. CAT scan use in short-stay nonfederal hospitals: United States, 1979-82 . Hyattsville, Md: National Center for Health Statistics, Public Health Service; 1984;. US Dept of Health and Human Services. Advance Data No. 100.
Howard G, Toole JF, Becker C, et al.  Changes in survival following stroke in five North Carolina counties observed during two different periods. Stroke . 1989;;20:345-350.
Caplan LR.  Diagnosis and treatment of ischemic stroke. JAMA . 1991;;266:2413-2418.
Biller J, Love BB, Gordon DL.  Antithrombotic therapy for ischemic cerebrovascular disease. Semin Neurol . 1991;;11:353-367.
Rothrock JF, Hart RG.  Antithrombotic therapy in cerebrovascular disease. Ann Intern Med . 1991;;115:885-895.
McGovern PG, Folsom AR, Sprafka JM, et al.  Trends in survival of hospitalized myocardial infarction patients between 1970 and 1985: the Minnesota Heart Survey. Circulation . 1992;;85:172-179.
Tillinghast SJ, Doliszny KM, Kottke TE, Gomez-Marin 0, Lilja GP, Campion BC.  Change in survival from out-of-hospital cardiac arrest and its effect on coronary heart disease mortality, Minneapolis-St Paul: the Minnesota Heart Survey. Am J Epidemiol . 1991;;134:851-861.
National Center for Health Statistics. Blood pressure levels in persons 18-74 years of age in 1976-1980, and trends in blood pressure from 1960 to 1980 in the United States . Hyattsville, Md: National Center for Health Statistics; 1972;. US Dept of Health and Human Services publication PHS 86-1684. Series 11.
National Center for Health Statistics, National Heart, Lung, and Blood Institute Collaborative Lipid Group.  Trends in serum cholesterol levels among US adults aged 20 to 74 years: data from the National Health and Nutrition Examination Surveys, 1960 to 1980. JAMA . 1987;;257:937-942.
National Center for Health Statistics. Prevention profile: health, United States, 1986 . Washington, DC: National Center for Health Statistics; 1976: 125-126. US Dept of Health and Human Services publication PHS 87-1232.
Bonita R, Beaglehole R.  Increased treatment of hypertension does not explain the decline in stroke mortality in the United States, 1970-1980. Hypertension . 1989;;13( (suppl I) ):I-69-I-73.
Klag MJ, Whelton PK, Seidler AJ.  Decline in US stroke mortality: demographic trends and antihypertensive treatment. Stroke . 1989;;20:14-21.
Rose G.  Ancel Keys lecture. Circulation . 1991;; 84:1405-1409.

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National Center for Health Statistics.  Advance report of final mortality statistics, 1986. Monthly Vital Stat Rep . 1992;;40( (suppl 2) ):1-55.
Dawson DA, Adams PF.  Current estimates from the National Center for Health Statistics. Vital Health Stat . 1987;;10:164.
WhisnantJP.  The decline of stroke. Stroke . 1984;; 15:160-168.
Gillum RF, Gomez-Marin 0, Kottke TE, et al.  Acute stroke in a metropolitan area, 1970 and 1980: the Minnesota Heart Survey. J Chronic Dis . 1985;; 38:8911-8918.
Folsom AR, Luepker RV, Gillum RF, et al.  Improvement of hypertension detection and control from 1973-1974 to 1981-1982: the Minnesota Heart Survey experience. JAMA . 1983;;250:916-921.
Luepker RV, Jacobs DR, Folsom AR, et al.  Cardiovascular risk factors—1973-74 to 1980-82: the Minnesota Heart Survey. J Clin Epidemiol . 1988;; 41:825-833.
World Health Organization. Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death, Based on the Recommendations of the Seventh Revision Conference, 1955 . Geneva, Switzerland: World Health Organization; 1957;.
World Health Organization. Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death, Based on the Recommendations of the Eighth Revision Conference, 1965 . Geneva, Switzerland: World Health Organization; 1967;.
World Health Organization. Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death, Based on the Recommendations of the Ninth Revision Conference, 1975 . Geneva, Switzerland: World Health Organization; 1977;.
National Center for Health Statistics. Comparability of mortality statistics for the seventh and eighth revisions of the International Classification of Diseases, United States . Rockville, Md: Dept of Health, Education, and Welfare; 1975;:66. Series 2.
National Center for Health Statistics.  Estimates of selected comparability ratios based on dual coding of 1976 death certificates by the eighth and ninth revisions of the International Classification of Diseases. Monthly Vital Stat Rep . 1980;;28( (suppl) ): 1-18.
Jacobs DRJr, Hunninghake DB, Dempsey ME, et al.  Blood lipids and lipoproteins in a Minnesota urban population. J Chronic Dis . 1980;;33:395-406.
Sprafka JM, Burke GL, Folsom AR, Luepker RV, Blackburn H.  Continued decline in cardiovascular disease risk factors: results from the Minnesota Heart Survey, 1980-82 to 1985-87. Am J Epidemiol . 1990;;132:489-500.
Jeffery RW, Folsom AR, Luepker RV, et al.  Prevalence of overweight and weight loss behavior in a metropolitan adult population: the Minnesota Heart Survey experience. Am J Public Health . 1984;;74:349-352.
SAS Institute Inc. SAS/STAT Guide . Version 6, 4th ed. Cary, NC: Statistical Analysis Systems Institute Inc; 1989;(1,2).
Edlavitch SA, Baxter J.  Comparability of mortality follow-up before and after the National Death Index. Am J Epidemiol . 1988;;127:1164-1178.
World Health Organization. World Health Statistics Annual . Geneva, Switzerland: World Health Organization; 1990;.
Gillum RF.  Cerebrovascular disease morbidity in the United States, 1970-1983: age, sex, region, and vascular surgery. Stroke . 1986;;17:656-661.
Centers for Disease Control.  Hospital discharge rates for cerebrovascular disease: United States, 1970-1986. MMWR . 1989;;38:194-201.
Broderick JP, Phillips SJ, Whisnant JP, O'Fallon WM, Bergstralh EJ.  Incidence rates of stroke in the eighties: the end of the decline in stroke? Stroke . 1989;;20:577-582.
Graves EJ. CAT scan use in short-stay nonfederal hospitals: United States, 1979-82 . Hyattsville, Md: National Center for Health Statistics, Public Health Service; 1984;. US Dept of Health and Human Services. Advance Data No. 100.
Howard G, Toole JF, Becker C, et al.  Changes in survival following stroke in five North Carolina counties observed during two different periods. Stroke . 1989;;20:345-350.
Caplan LR.  Diagnosis and treatment of ischemic stroke. JAMA . 1991;;266:2413-2418.
Biller J, Love BB, Gordon DL.  Antithrombotic therapy for ischemic cerebrovascular disease. Semin Neurol . 1991;;11:353-367.
Rothrock JF, Hart RG.  Antithrombotic therapy in cerebrovascular disease. Ann Intern Med . 1991;;115:885-895.
McGovern PG, Folsom AR, Sprafka JM, et al.  Trends in survival of hospitalized myocardial infarction patients between 1970 and 1985: the Minnesota Heart Survey. Circulation . 1992;;85:172-179.
Tillinghast SJ, Doliszny KM, Kottke TE, Gomez-Marin 0, Lilja GP, Campion BC.  Change in survival from out-of-hospital cardiac arrest and its effect on coronary heart disease mortality, Minneapolis-St Paul: the Minnesota Heart Survey. Am J Epidemiol . 1991;;134:851-861.
National Center for Health Statistics. Blood pressure levels in persons 18-74 years of age in 1976-1980, and trends in blood pressure from 1960 to 1980 in the United States . Hyattsville, Md: National Center for Health Statistics; 1972;. US Dept of Health and Human Services publication PHS 86-1684. Series 11.
National Center for Health Statistics, National Heart, Lung, and Blood Institute Collaborative Lipid Group.  Trends in serum cholesterol levels among US adults aged 20 to 74 years: data from the National Health and Nutrition Examination Surveys, 1960 to 1980. JAMA . 1987;;257:937-942.
National Center for Health Statistics. Prevention profile: health, United States, 1986 . Washington, DC: National Center for Health Statistics; 1976: 125-126. US Dept of Health and Human Services publication PHS 87-1232.
Bonita R, Beaglehole R.  Increased treatment of hypertension does not explain the decline in stroke mortality in the United States, 1970-1980. Hypertension . 1989;;13( (suppl I) ):I-69-I-73.
Klag MJ, Whelton PK, Seidler AJ.  Decline in US stroke mortality: demographic trends and antihypertensive treatment. Stroke . 1989;;20:14-21.
Rose G.  Ancel Keys lecture. Circulation . 1991;; 84:1405-1409.
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