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Academic-Industry Relationships in the Life Sciences: Title and subTitle BreakExtent, Consequences, and Management FREE

David Blumenthal, MD, MPP
[+] Author Affiliations

Reprint requests to Health Policy Research and Development Unit, Massachusetts General Hospital, Boston, MA 02114 (Dr Blumenthal).


JAMA. 1992;268(23):3344-3349. doi:10.1001/jama.1992.03490230074031
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Academic-industry relationships in the life sciences remain controversial. The available evidence suggests that such relationships have both benefits and risks for involved parties. Benefits include additional support of academic research, income for academic health centers, the potential for increased scientific and commercial productivity in both industries and universities, and enhancement of the educational experiences of students and fellows. Risks include an increase in secrecy in academic environments and damage to public support for the life science enterprise. The balance of known benefits and risks suggests that academic-industry relationships should be permitted and even selectively promoted. However, there is also a need for enhanced vigilance on the part of academic institutions and government to reduce risks posed by certain types of arrangements, especially those involving human subjects. Enhanced vigilance should include disclosure of all academic-industry relationships by life science faculty.

(JAMA. 1992;268:3344-3349)

REFERENCES

General Accounting Office. Controlling Inappropriate Access to Federally Funded Research Results . Washington, DC: US General Accounting Office; 1992;. General Accounting Office publication RCED-92-104.
Hearings Before the Committee on Government Operations of the Human Resources and Intergovernmental Relations Subcommittee, 101st Cong, 1st Sess (June 13,1989) (Is Science for Sale? Conflicts of Interest v the Public Interest).
Hearings Before the Committee on Government Operations of the Human Resources and Intergovernmental Relations Subcommittee, 101st Cong, 1st Sess (June 13,1989) (Is Science for Sale? Conflicts of Interest v the Public Interest [testimony of David Blumenthal, MD]).
Office of Technology Assessment. New Developments in Biotechnology . Washington, DC: US Congress; 1988;.
Abelson PH.  Industrial interactions with universities. Science . 1991;;252:9.
Etzkowitz H.  Entrepreneurial science in the academy: a case of the transformation of norms. Soc Problems . 1989;;36:14-29.
Merton RK.  Science and technology in a democratic order. J Leg Polit Sci . 1942;;1:15-26.
Krimsky S, Ennis JG, Weissman R.  Academiccorporate ties in biotechnology: a quantitative study. Sci Technol Human Values . 1991;;16:275-287.
Webster A, Etzkowitz H. Academic-Industry Relations: The Second Academic Revolution? London, England: Science Policy Support Group; 1991;. Concept paper No. 12.
Blumenthal D, Gluck M, Louis KS, Stoto MA, Wise D.  University-industry relationships in biotechnology: implications for the university. Science . 1986;;232:1361-1366.
Kenney M. Biotechnology: The University-Industrial Complex . New Haven, Conn: Yale University Press; 1986;.
Blumenthal D, Gluck M, Louis KS, Wise D.  Industrial support of university research in biotechnology. Science . 1986;;231:242-246.
Palca J.  NSF centers rise above the storm. Science . 1991;;251:19-22.
Marshall E.  When commerce and academia collide. Science . 1990;;248:152-156.
Chen PS.  The National Institutes of Health and its interactions with industry.  In: Porter RJ, Malone TE, eds. Biomedical Research: Collaboration and Conflict of Interest . Baltimore, Md: The Johns Hopkins University Press; 1992;.
Boston Globe. BU trustees Jay Seragen tops goals. November 17, 1989;sect A:19.
 Potential conflict foreseen for BU: trustees' stock brought into question. Boston Globe . (May 11) , 1990;;sect A:26.
Blumenthal D, Gluck M, Epstein S, Louis KS, Stoto MA. University-Industry Relationships in Biotechnology: Implications for Federal Policy: Final Report . 1987;. US Dept of Health and Human Services grant 100A-83. Unpublished.
Gluck M, Blumenthal D, Stoto MA.  University-industry relationships in the life sciences: implications for students and postdoctoral fellows. Res Policy . 1987;;16:327-336.
Etzkowitz H. Changing academic structures and goals. Presented at the NATO Research Workshop on Academic Industry Relationships; September 2, 1991; Aquafredda, Italy.
Feller I.  Universities as engines of R&D-based economic growth: they think they can. Res Policy . 1990;;19:335-348.
Shapiro HT. The research university and the economy. Presented at the National Academy of Engineering Symposium: The Role of Universities in National Economic Development; December 6, 1990; Washington, DC.
Palci J.  Conflict of interest: PHS readies new rules. Science . 1990;;249:1237.
Shulman S.  Fierce debate at Harvard. Nature . 1990;;344:97.
Harvard University Faculty of Medicine. Faculty Policies on Integrity in Science . (January 2) , 1992;.
The Johns Hopkins University School of Medicine. Faculty Policies . 1990;.
Request for Comment on Proposed Guidelines for Policies on Conflict of Interest Developed by the National Institutes of Health and The Alcohol Drug Abuse and Mental Health Administration . Washington, DC: September 15, 1989;.
Pramik HJ.  NIH redrafts its guidelines to cover conflicts of interest. Genetic Engineering News . 1990;; 10:1.
Mervis J.  NIH rebuffed, rethinks new ethics regulations. Scientist . (February 5) , 1990;.
Government - University - Industry Research Roundtable. Industrial Perspectives on Innovation and Interactions With Universities . Washington, DC: National Academy Press; 1991;.

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General Accounting Office. Controlling Inappropriate Access to Federally Funded Research Results . Washington, DC: US General Accounting Office; 1992;. General Accounting Office publication RCED-92-104.
Hearings Before the Committee on Government Operations of the Human Resources and Intergovernmental Relations Subcommittee, 101st Cong, 1st Sess (June 13,1989) (Is Science for Sale? Conflicts of Interest v the Public Interest).
Hearings Before the Committee on Government Operations of the Human Resources and Intergovernmental Relations Subcommittee, 101st Cong, 1st Sess (June 13,1989) (Is Science for Sale? Conflicts of Interest v the Public Interest [testimony of David Blumenthal, MD]).
Office of Technology Assessment. New Developments in Biotechnology . Washington, DC: US Congress; 1988;.
Abelson PH.  Industrial interactions with universities. Science . 1991;;252:9.
Etzkowitz H.  Entrepreneurial science in the academy: a case of the transformation of norms. Soc Problems . 1989;;36:14-29.
Merton RK.  Science and technology in a democratic order. J Leg Polit Sci . 1942;;1:15-26.
Krimsky S, Ennis JG, Weissman R.  Academiccorporate ties in biotechnology: a quantitative study. Sci Technol Human Values . 1991;;16:275-287.
Webster A, Etzkowitz H. Academic-Industry Relations: The Second Academic Revolution? London, England: Science Policy Support Group; 1991;. Concept paper No. 12.
Blumenthal D, Gluck M, Louis KS, Stoto MA, Wise D.  University-industry relationships in biotechnology: implications for the university. Science . 1986;;232:1361-1366.
Kenney M. Biotechnology: The University-Industrial Complex . New Haven, Conn: Yale University Press; 1986;.
Blumenthal D, Gluck M, Louis KS, Wise D.  Industrial support of university research in biotechnology. Science . 1986;;231:242-246.
Palca J.  NSF centers rise above the storm. Science . 1991;;251:19-22.
Marshall E.  When commerce and academia collide. Science . 1990;;248:152-156.
Chen PS.  The National Institutes of Health and its interactions with industry.  In: Porter RJ, Malone TE, eds. Biomedical Research: Collaboration and Conflict of Interest . Baltimore, Md: The Johns Hopkins University Press; 1992;.
Boston Globe. BU trustees Jay Seragen tops goals. November 17, 1989;sect A:19.
 Potential conflict foreseen for BU: trustees' stock brought into question. Boston Globe . (May 11) , 1990;;sect A:26.
Blumenthal D, Gluck M, Epstein S, Louis KS, Stoto MA. University-Industry Relationships in Biotechnology: Implications for Federal Policy: Final Report . 1987;. US Dept of Health and Human Services grant 100A-83. Unpublished.
Gluck M, Blumenthal D, Stoto MA.  University-industry relationships in the life sciences: implications for students and postdoctoral fellows. Res Policy . 1987;;16:327-336.
Etzkowitz H. Changing academic structures and goals. Presented at the NATO Research Workshop on Academic Industry Relationships; September 2, 1991; Aquafredda, Italy.
Feller I.  Universities as engines of R&D-based economic growth: they think they can. Res Policy . 1990;;19:335-348.
Shapiro HT. The research university and the economy. Presented at the National Academy of Engineering Symposium: The Role of Universities in National Economic Development; December 6, 1990; Washington, DC.
Palci J.  Conflict of interest: PHS readies new rules. Science . 1990;;249:1237.
Shulman S.  Fierce debate at Harvard. Nature . 1990;;344:97.
Harvard University Faculty of Medicine. Faculty Policies on Integrity in Science . (January 2) , 1992;.
The Johns Hopkins University School of Medicine. Faculty Policies . 1990;.
Request for Comment on Proposed Guidelines for Policies on Conflict of Interest Developed by the National Institutes of Health and The Alcohol Drug Abuse and Mental Health Administration . Washington, DC: September 15, 1989;.
Pramik HJ.  NIH redrafts its guidelines to cover conflicts of interest. Genetic Engineering News . 1990;; 10:1.
Mervis J.  NIH rebuffed, rethinks new ethics regulations. Scientist . (February 5) , 1990;.
Government - University - Industry Research Roundtable. Industrial Perspectives on Innovation and Interactions With Universities . Washington, DC: National Academy Press; 1991;.
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