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Evidence-Based Medicine: Title and subTitle BreakA New Approach to Teaching the Practice of Medicine FREE

Gordon Guyatt, MD, MSc; John Cairns, MD; David Churchill, MD, MSc; Deborah Cook, MD, MSc; Brian Haynes, MD, MSc, PhD; Jack Hirsh, MD; Jan Irvine, MD, MSc; Mark Levine, MD, MSc; Mitchell Levine, MD, MSc; Jim Nishikawa, MD; David Sackett, MD, MSc; Patrick Brill-Edwards, MD; Hertzel Gerstein, MD, MSc; Jim Gibson, MD; Roman Jaeschke, MD, MSc; Anthony Kerigan, MD, MSc; Alan Neville, MD; Akbar Panju, MD; Allan Detsky, MD, PhD; Murray Enkin, MD; Pamela Frid, MD; Martha Gerrity, MD; Andreas Laupacis, MD, MSc; Valerie Lawrence, MD; Joel Menard, MD; Virginia Moyer, MD; Cynthia Mulrow, MD; Paul Links, MD, MSc; Andrew Oxman, MD, MSc; Jack Sinclair, MD; Peter Tugwell, MD, MSc
[+] Author Affiliations

A complete list of members of the Evidenced-Based Medicine Working Group appears at the end of this article.

Reprint requests to McMaster University Health Sciences Centre, Room 3W10,1200 Main St W, Hamilton, Ontario, Canada L8N 3Z5 (Gordon Guyatt, MD).


JAMA. 1992;268(17):2420-2425. doi:10.1001/jama.1992.03490170092032
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A NEW paradigm for medical practice is emerging. Evidence-based medicine de-emphasizes intuition, unsystematic clinical experience, and pathophysiologic rationale as sufficient grounds for clinical decision making and stresses the examination of evidence from clinical research. Evidence-based medicine requires new skills of the physician, including efficient literature searching and the application of formal rules of evidence evaluating the clinical literature.

An important goal of our medical residency program is to educate physicians in the practice of evidence-based medicine. Strategies include a weekly, formal academic half-day for residents, devoted to learning the necessary skills; recruitment into teaching roles of physicians who practice evidence-based medicine; sharing among faculty of approaches to teaching evidence-based medicine; and providing faculty with feedback on their performance as role models and teachers of evidence-based medicine. The influence of evidencebased medicine on clinical practice and medical education is increasing.

CLINICAL SCENARIO  A junior medical resident working in a teaching hospital

REFERENCES

Lindberg DA.  Information systems to support medical practice and scientific discovery. Methods Inform Med . 1989;;28:202-206.
Hart YM, Sander JW, Johnson AL, Shorvon SD.  National general practice study of epilepsy: recurrence after a first seizure. Lancet . 1990;;336:1271-1274.
Sackett DL, Haynes RB, Guyatt GH, Tugwell P. Clinical Epidemiology: A Basic Science for Clinicial Medicine . 2nd ed. Boston, Mass: Little Brown & Co Inc; 1991;:173-186.
Kuhn TS. The Structure of Scientific Revolutions . Chicago, Ill: University of Chicago Press; 1970;.
European Carotid Surgery Trialists' Collaborative Group.  MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70-99%) or with mild (0-29%) carotid stenosis. Lancet . 1991;;337:1235-1243.
Larsen ML, Horder M, Mogensen EF.  Effect of long-term monitoring of glycosylated hemoglobin levels in insulin-dependent diabetes mellitus. N Engl J Med . 1990;;323:1021-1025.
L'Abbe KA, Detsky AS, O'Rourke K.  Meta-analysis in clinical research. Ann Intern Med . 1987;;107: 224-233.
Ransohoff DF, Feinstein AR.  Problems of spectrum and bias in evaluating the efficacy of diagnostic tests. N Engl J Med . 1978;;299:926-930.
Nierenberg AA, Feinstein AR.  How to evaluate a diagnostic market test: lessons from the rise and fall of dexamethasone suppression test. JAMA . 1988;; 259:1699-1702.
Haynes RB, McKibbon KA, Fitzgerald D, Guyatt GH, Walker CJ, Sackett DL.  How to keep up with the medical literature, V: access by personal computer to the medical literature. Ann Intern Med . 1986;;105:810-816.
Bulpitt CJ.  Confidence intervals. Lancet . 1987;; 1:494-497.
Godfrey K.  Simple linear regression in medical research. N Engl J Med . 1985;;313:1629-1636.
Haynes RB, Mulrow CD, Huth EJ, Altman DG, Gardner MJ.  More informative abstracts revisited. Ann Intern Med . 1990;;113:69-76.
Haynes RB.  The origins and aspirations of ACP Journal Club. Ann Intern Med . 1991;;114(ACP J Club. (suppl 1) ):A18.
Chalmers I, Enkin M, Keirse MJNC, eds. Effective Care in Pregnancy and Childbirth . New York, NY: Oxford University Press Inc; 1989;.
Sinclair JC, Braken MB, eds. Effective Care of the Newborn Infant . New York, NY: Oxford University Press Inc; 1992;.
Audet AM, Greenfield S, Field M.  Medical practice guidelines: current activities and future directions. Ann Intern Med . 1990;;113:709-714.
Guyatt GH.  Evidence-based medicine. Ann Intern Med . 1991;;114(ACP J Club. (suppl 2) ):A-16.
Light DW.  Uncertainty and control in professional training. J Health Soc Behav . 1979;;20:310-322.
Chalmers I.  Scientific inquiry and authoritarianism in perinatal care and education. Birth . 1983;; 10:151-164.
Cassell EJ.  The nature of suffering and the goals of medicine. N Engl J Med . 1982;;306:639-645.
Ende J, Kazis L, Ash A, Moskowitz MA.  Measuring patients' desire for autonomy: decision-making and information-seeking preferences among medical patients. J Gen Intern Med . 1989;;4:23-30.
Carter WB, Inui TS, Kukull WA, Haigh VH.  Outcome-based doctor-patient interaction analysis. Med Care . 1982;;20:550-556.
Greenfield S, Kaplan S, Ware JE Jr.  Expanding patient involvement in care: effects on patient outcomes. Ann Intern Med . 1985;;102:520-528.
Haynes RB, McKibbon A, Walker CJ, Ryan N, Fitzgerald D, Ramsden ME.  Online access to MEDLINE in clinical settings: a study of use and usefulness. Ann Intern Med . 1990;;112:78-84.
McKibbon KA, Haynes RB, Johnston ME, Walker CJ.  A study to enhance clinical end-user MEDLINE search skills: design and baseline findings.  In: Clayton PD, ed. Proceedings of the Fifth Annual Symposium on Computer Applications in Medical Care, November 1991; Washington, DC . New York, NY: McGraw-Hill International Book Co; 1992;:73-77.
Laupacis A, Sackett DL, Roberts RS.  An assessment of clinically useful measures of the consequences of treatment. N Engl J Med . 1988;;318: 1728-1733.
Department of Clinical Epidemiology and Biostatistics, McMaster University.  How to read clinical journals, II: to learn about a diagnostic test. Can Med Assoc J . 1981;;124:703-710.
Department of Clinical Epidemiology and Biostatistics, McMaster University.  How to read clinical journals, V: to distinguish useful from useless or even harmful therapy. Can Med Assoc J . 1981;; 124:1156-1162.
Oxman AD, Guyatt GH.  Guidelines for reading literature reviews. Can Med Assoc J . 1988;;138:697-703.
Campbell EJM.  The diagnosing mind. Lancet . 1987;;1:849-851.
Feinstein AR.  What kind of basic science for clinical medicine? N Engl J Med . 1970;;283:847-853.
Mulrow CD.  The medical review article: state of the science. Ann Intern Med . 1987;;106:485-488.
Eddy DM.  Guidelines for policy statements: the explicit approach. JAMA . 1990;;263:2239-2243.
Bennett KJ, Sackett DL, Haynes RB, et al.  A controlled trial of teaching critical appraisal of the clinical literature to medical students. JAMA . 1987;; 257:2451-2454.
Kitchens JM, Pfeifer MP.  Teaching residents to read the medical literature: a controlled trial of a curriculum in critical appraisal/clinical epidemiology. J Gen Intern Med . 1989;;4:384-387.
Shin J, Haynes RB.  Does a problem-based, selfdirected undergraduate medical curriculum promote continuing clinical competence? Clin Res . 1991;; 39:143A.

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Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Lindberg DA.  Information systems to support medical practice and scientific discovery. Methods Inform Med . 1989;;28:202-206.
Hart YM, Sander JW, Johnson AL, Shorvon SD.  National general practice study of epilepsy: recurrence after a first seizure. Lancet . 1990;;336:1271-1274.
Sackett DL, Haynes RB, Guyatt GH, Tugwell P. Clinical Epidemiology: A Basic Science for Clinicial Medicine . 2nd ed. Boston, Mass: Little Brown & Co Inc; 1991;:173-186.
Kuhn TS. The Structure of Scientific Revolutions . Chicago, Ill: University of Chicago Press; 1970;.
European Carotid Surgery Trialists' Collaborative Group.  MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70-99%) or with mild (0-29%) carotid stenosis. Lancet . 1991;;337:1235-1243.
Larsen ML, Horder M, Mogensen EF.  Effect of long-term monitoring of glycosylated hemoglobin levels in insulin-dependent diabetes mellitus. N Engl J Med . 1990;;323:1021-1025.
L'Abbe KA, Detsky AS, O'Rourke K.  Meta-analysis in clinical research. Ann Intern Med . 1987;;107: 224-233.
Ransohoff DF, Feinstein AR.  Problems of spectrum and bias in evaluating the efficacy of diagnostic tests. N Engl J Med . 1978;;299:926-930.
Nierenberg AA, Feinstein AR.  How to evaluate a diagnostic market test: lessons from the rise and fall of dexamethasone suppression test. JAMA . 1988;; 259:1699-1702.
Haynes RB, McKibbon KA, Fitzgerald D, Guyatt GH, Walker CJ, Sackett DL.  How to keep up with the medical literature, V: access by personal computer to the medical literature. Ann Intern Med . 1986;;105:810-816.
Bulpitt CJ.  Confidence intervals. Lancet . 1987;; 1:494-497.
Godfrey K.  Simple linear regression in medical research. N Engl J Med . 1985;;313:1629-1636.
Haynes RB, Mulrow CD, Huth EJ, Altman DG, Gardner MJ.  More informative abstracts revisited. Ann Intern Med . 1990;;113:69-76.
Haynes RB.  The origins and aspirations of ACP Journal Club. Ann Intern Med . 1991;;114(ACP J Club. (suppl 1) ):A18.
Chalmers I, Enkin M, Keirse MJNC, eds. Effective Care in Pregnancy and Childbirth . New York, NY: Oxford University Press Inc; 1989;.
Sinclair JC, Braken MB, eds. Effective Care of the Newborn Infant . New York, NY: Oxford University Press Inc; 1992;.
Audet AM, Greenfield S, Field M.  Medical practice guidelines: current activities and future directions. Ann Intern Med . 1990;;113:709-714.
Guyatt GH.  Evidence-based medicine. Ann Intern Med . 1991;;114(ACP J Club. (suppl 2) ):A-16.
Light DW.  Uncertainty and control in professional training. J Health Soc Behav . 1979;;20:310-322.
Chalmers I.  Scientific inquiry and authoritarianism in perinatal care and education. Birth . 1983;; 10:151-164.
Cassell EJ.  The nature of suffering and the goals of medicine. N Engl J Med . 1982;;306:639-645.
Ende J, Kazis L, Ash A, Moskowitz MA.  Measuring patients' desire for autonomy: decision-making and information-seeking preferences among medical patients. J Gen Intern Med . 1989;;4:23-30.
Carter WB, Inui TS, Kukull WA, Haigh VH.  Outcome-based doctor-patient interaction analysis. Med Care . 1982;;20:550-556.
Greenfield S, Kaplan S, Ware JE Jr.  Expanding patient involvement in care: effects on patient outcomes. Ann Intern Med . 1985;;102:520-528.
Haynes RB, McKibbon A, Walker CJ, Ryan N, Fitzgerald D, Ramsden ME.  Online access to MEDLINE in clinical settings: a study of use and usefulness. Ann Intern Med . 1990;;112:78-84.
McKibbon KA, Haynes RB, Johnston ME, Walker CJ.  A study to enhance clinical end-user MEDLINE search skills: design and baseline findings.  In: Clayton PD, ed. Proceedings of the Fifth Annual Symposium on Computer Applications in Medical Care, November 1991; Washington, DC . New York, NY: McGraw-Hill International Book Co; 1992;:73-77.
Laupacis A, Sackett DL, Roberts RS.  An assessment of clinically useful measures of the consequences of treatment. N Engl J Med . 1988;;318: 1728-1733.
Department of Clinical Epidemiology and Biostatistics, McMaster University.  How to read clinical journals, II: to learn about a diagnostic test. Can Med Assoc J . 1981;;124:703-710.
Department of Clinical Epidemiology and Biostatistics, McMaster University.  How to read clinical journals, V: to distinguish useful from useless or even harmful therapy. Can Med Assoc J . 1981;; 124:1156-1162.
Oxman AD, Guyatt GH.  Guidelines for reading literature reviews. Can Med Assoc J . 1988;;138:697-703.
Campbell EJM.  The diagnosing mind. Lancet . 1987;;1:849-851.
Feinstein AR.  What kind of basic science for clinical medicine? N Engl J Med . 1970;;283:847-853.
Mulrow CD.  The medical review article: state of the science. Ann Intern Med . 1987;;106:485-488.
Eddy DM.  Guidelines for policy statements: the explicit approach. JAMA . 1990;;263:2239-2243.
Bennett KJ, Sackett DL, Haynes RB, et al.  A controlled trial of teaching critical appraisal of the clinical literature to medical students. JAMA . 1987;; 257:2451-2454.
Kitchens JM, Pfeifer MP.  Teaching residents to read the medical literature: a controlled trial of a curriculum in critical appraisal/clinical epidemiology. J Gen Intern Med . 1989;;4:384-387.
Shin J, Haynes RB.  Does a problem-based, selfdirected undergraduate medical curriculum promote continuing clinical competence? Clin Res . 1991;; 39:143A.
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