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November 4, 1992, Vol 268, No. 17 >
ARTICLE | November 4, 1992

Gene Therapy for Cancer FREE

Steven A. Rosenberg, MD, PhD
[+] Author Affiliations

Reprint requests to Surgery Branch, National Cancer Institute, National Institutes of Health, Bldg 10, Room 2B42, Bethesda, MD 20892 (Dr Rosenberg).


JAMA. 1992;268(17):2416-2419. doi:10.1001/jama.1992.03490170088031
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References

SELECTED CASES 

CASE 1.  —A 26-year-old woman was referred to the Surgery Branch, National Cancer Institute, Bethesda, Md, with metastatic melanoma. A year earlier the patient had noted an enlarging mole on her right upper extremity; the results of the biopsy revealed a melanoma. She underwent a wide local excision and right axillary lymph node dissection. Of 30 lymph nodes, two contained melanoma. Despite experimental treatment with vaccinia tumor oncolysate, her disease progressed. On presentation to the National Institutes of Health in June 1989, she had about 30 subcutaneous deposits of melanoma, multiple lung metastases, and oral lesions on her tonsils and soft palate. On June 21,1989, she underwent resection of six separate subcutaneous lesions ranging in diameter from 2 to 5 cm to harvest tumor-infiltrating lymphocytes (TIL) (T cells that infiltrate into animal and human tumors and can be grown in culture with interleukin 2 [IL-2]).1 Eight days

REFERENCES

1 +
Topalian SL, Rosenberg SA.  Tumor-infiltrating lymphocytes (TIL): evidence for specific immune reactions against growing cancers in mice and humans. Important Adv Oncol . 1990;:19-41.
2 +
Rosenberg SA.  The immunotherapy and gene therapy of cancer. J Clin Oncol . 1992;;10:180-199.
3 +
Rosenberg SA.  Adoptive cellular therapy: clinical applications.  In: DeVita VT, Hellman S, Rosenberg SA, eds. Biologic Therapy of Cancer . Philadelphia, Pa: JB Lippincott; 1991;:214-236.
4 +
Rosenberg SA, Aebersold PM, Cornetta K, et al.  Gene transfer into humans: immunotherapy of patients with advanced melanoma using tumor-infiltrating lymphocytes modified by retroviral gene transduction. N Engl J Med . 1990;;323:570-578.
5 +
Kriegler M. Gene Transfer and Expression: A Laboratory Manual . New York, NY: Stockton Press; 1990;:1.
6 +
Friedmann T.  Progress toward human gene therapy. Science . 1989;;244:1275-1281.
7 +
Rosenberg SA, Spiess P, Lafreniere R.  A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes. Science . 1986;; 233:1318-1321.
8 +
Rosenberg SA, Packard BS, Aebersold PM, et al.  Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma: a preliminary report. N Engl J Med . 1988;;319:1676-1680.
9 +
Fisher B, Packard BS, Read EJ, et al.  Tumor localization of adoptively transferred indium-111 labeled tumor-infiltrating lymphocytes in patients with metastatic melanoma. J Clin Oncol . 1989;;7: 250-261.
10 +
Griffith KD, Read EJ, Carrasquillo JA, et al.  In vivo distribution of adoptively transferred indium-111 labeled tumor-infiltrating lymphocytes and peripheral blood lymphocytes in patients with metastatic melanoma. J Natl Cancer Inst . 1989;;81:1709-1717.
11 +
Kasid A, Morecki S, Aebersold P, et al.  Human gene transfer: characterization of human tumor-infiltrating lymphocytes as vehicles for retroviral mediated gene transfer in man. Proc Natl Acad Sci U S A . 1990;;87:473-477.
12 +
Morecki S, Karson E, Cornetta K, et al.  Retrovirus-mediated gene transfer into CD4+ and CD8+ human T-cell subsets derived from tumor-infiltrating lymphocytes and peripheral blood mononuclear cells. Cancer Immunol Immunother . 1991;; 32:342-352.
13 +
Cornetta K, Morgan RA, Anderson WF.  Safety issues related to retroviral-mediated gene transfer in humans. Hum Gene Ther . 1991;;2:5-14.
14 +
Bender MA, Palmer TD, Gelinas RE, et al.  Evidence that the packaging signal of Moloney murine leukemia virus extends into the gag region. J Virol . 1987;;61:1639-1646.
15 +
Alexander RB, Rosenberg SA.  Tumor necrosis factor: clinical applications.  In: DeVita VT, Hellman S, Rosenberg SA, eds. Biologic Therapy of Cancer . Philadelphia, Pa: JB Lippincott; 1991;:378-392.
16 +
Gross G, Waks T, Eshhar Z.  Expression of immunoglobulin—T-cell receptor chimeric molecules as functional receptors with antibody-type specificity. Proc Natl Acad Sci U S A . 1989;;86:10024-10028.
17 +
Tepper RI, Pattengale PK, Leder P.  Murine interleukin-4 displays potent antitumor activity in vivo. Cell . 1989;;57:503-512.
18 +
Fearon ER, Pardoll DM, Itaya T, et al.  Interleukin-2 production by tumor cells bypasses T-helper function in the generation of an antitumor response. Cell . 1990;;60:397-403.
19 +
Asher AL, Mule JJ, Kasid A, et al.  Murine tumor cells transduced with the gene for TNF-alpha: evidence for paracrine immune effects of TNF against tumors. J Immunol . 1991;;146:3227-3234.
20 +
Gansbacher B, Bannerji R, Daniels B, et al.  Retroviral vector-mediated γ-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity. Cancer Res . 1990;;50:7820-7825.
21 +
Colombo MP, Ferrari G, Stoppacciaro A, et al.  Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo. J Exp Med . 1991;;173:889-897.
22 +
Horn SS, Topalian SL, Simoni ST, Mancini MJ, Rosenberg SA.  Common expression of melanoma tumor-associated antigens recognized by human tumor-infiltrating lymphocytes: analysis by HLA restriction. J Immunother . 1991;;10:153-164.
23 +
Kawakami Y, Zakut R, Topalian SL, Stotter H, Rosenberg SA.  Shared human melanoma antigens: recognition by tumor-infiltrating lymphocytes in HLA-A2.1 transfected melanomas. J Immunol . 1992;;148:638-643.
24 +
Van der Bruggen P, Traversari C, Chomez P, et al.  A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science . 1991;;254:1643-1647.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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1 +
Topalian SL, Rosenberg SA.  Tumor-infiltrating lymphocytes (TIL): evidence for specific immune reactions against growing cancers in mice and humans. Important Adv Oncol . 1990;:19-41.
2 +
Rosenberg SA.  The immunotherapy and gene therapy of cancer. J Clin Oncol . 1992;;10:180-199.
3 +
Rosenberg SA.  Adoptive cellular therapy: clinical applications.  In: DeVita VT, Hellman S, Rosenberg SA, eds. Biologic Therapy of Cancer . Philadelphia, Pa: JB Lippincott; 1991;:214-236.
4 +
Rosenberg SA, Aebersold PM, Cornetta K, et al.  Gene transfer into humans: immunotherapy of patients with advanced melanoma using tumor-infiltrating lymphocytes modified by retroviral gene transduction. N Engl J Med . 1990;;323:570-578.
5 +
Kriegler M. Gene Transfer and Expression: A Laboratory Manual . New York, NY: Stockton Press; 1990;:1.
6 +
Friedmann T.  Progress toward human gene therapy. Science . 1989;;244:1275-1281.
7 +
Rosenberg SA, Spiess P, Lafreniere R.  A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes. Science . 1986;; 233:1318-1321.
8 +
Rosenberg SA, Packard BS, Aebersold PM, et al.  Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma: a preliminary report. N Engl J Med . 1988;;319:1676-1680.
9 +
Fisher B, Packard BS, Read EJ, et al.  Tumor localization of adoptively transferred indium-111 labeled tumor-infiltrating lymphocytes in patients with metastatic melanoma. J Clin Oncol . 1989;;7: 250-261.
10 +
Griffith KD, Read EJ, Carrasquillo JA, et al.  In vivo distribution of adoptively transferred indium-111 labeled tumor-infiltrating lymphocytes and peripheral blood lymphocytes in patients with metastatic melanoma. J Natl Cancer Inst . 1989;;81:1709-1717.
11 +
Kasid A, Morecki S, Aebersold P, et al.  Human gene transfer: characterization of human tumor-infiltrating lymphocytes as vehicles for retroviral mediated gene transfer in man. Proc Natl Acad Sci U S A . 1990;;87:473-477.
12 +
Morecki S, Karson E, Cornetta K, et al.  Retrovirus-mediated gene transfer into CD4+ and CD8+ human T-cell subsets derived from tumor-infiltrating lymphocytes and peripheral blood mononuclear cells. Cancer Immunol Immunother . 1991;; 32:342-352.
13 +
Cornetta K, Morgan RA, Anderson WF.  Safety issues related to retroviral-mediated gene transfer in humans. Hum Gene Ther . 1991;;2:5-14.
14 +
Bender MA, Palmer TD, Gelinas RE, et al.  Evidence that the packaging signal of Moloney murine leukemia virus extends into the gag region. J Virol . 1987;;61:1639-1646.
15 +
Alexander RB, Rosenberg SA.  Tumor necrosis factor: clinical applications.  In: DeVita VT, Hellman S, Rosenberg SA, eds. Biologic Therapy of Cancer . Philadelphia, Pa: JB Lippincott; 1991;:378-392.
16 +
Gross G, Waks T, Eshhar Z.  Expression of immunoglobulin—T-cell receptor chimeric molecules as functional receptors with antibody-type specificity. Proc Natl Acad Sci U S A . 1989;;86:10024-10028.
17 +
Tepper RI, Pattengale PK, Leder P.  Murine interleukin-4 displays potent antitumor activity in vivo. Cell . 1989;;57:503-512.
18 +
Fearon ER, Pardoll DM, Itaya T, et al.  Interleukin-2 production by tumor cells bypasses T-helper function in the generation of an antitumor response. Cell . 1990;;60:397-403.
19 +
Asher AL, Mule JJ, Kasid A, et al.  Murine tumor cells transduced with the gene for TNF-alpha: evidence for paracrine immune effects of TNF against tumors. J Immunol . 1991;;146:3227-3234.
20 +
Gansbacher B, Bannerji R, Daniels B, et al.  Retroviral vector-mediated γ-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity. Cancer Res . 1990;;50:7820-7825.
21 +
Colombo MP, Ferrari G, Stoppacciaro A, et al.  Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo. J Exp Med . 1991;;173:889-897.
22 +
Horn SS, Topalian SL, Simoni ST, Mancini MJ, Rosenberg SA.  Common expression of melanoma tumor-associated antigens recognized by human tumor-infiltrating lymphocytes: analysis by HLA restriction. J Immunother . 1991;;10:153-164.
23 +
Kawakami Y, Zakut R, Topalian SL, Stotter H, Rosenberg SA.  Shared human melanoma antigens: recognition by tumor-infiltrating lymphocytes in HLA-A2.1 transfected melanomas. J Immunol . 1992;;148:638-643.
24 +
Van der Bruggen P, Traversari C, Chomez P, et al.  A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science . 1991;;254:1643-1647.

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