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ARTICLE |

Body Compositional Changes in Response to Testosterone FREE

Gregg Coodley, MD; Linn Goldberg, MD; Diane L. Elliot, MD
JAMA. 1992;267(19):2606-2606. doi:10.1001/jama.1992.03480190048027
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To the Editor.  —In their recent article, Forbes et al1 reported a trial of testosterone enanthate in seven healthy volunteers, noting a transient coincident increase in lean body mass and decrease in body fat. The authors seemed to imply that steroids are more effective than exercise in increasing lean body mass.1 We are concerned that this article may give the impression that anabolic steroids are a safe and reasonable approach to increasing muscle mass with minimal untoward clinical effects.Anabolic steroids have several potential adverse side effects.2,3 We would be interested in knowing whether there was any effect on blood pressure, hepatic enzymes, or mood in this study. Anabolic steroids also adversely affect lipid profiles.2,3 Were these measured before or after the study? In addition, because illicit use of anabolic steroids often is to increase strength as well as mass, it is important to note that

REFERENCES

Forbes GB, Porta CR, Herr BE, Griggs RC.  Sequence of changes in body composition induced by testosterone and reversal of changes after drug is stopped. JAMA . 1992;;267:397-399.
Council on Scientific Affairs, American Medical Association.  Medical and non-medical uses of anabolic androgenic steroids. JAMA . 1990;;264:2923-2927.
Hurley BF, Jeals DR, Hagerg JM, et al.  High-density lipoprotein cholesterol in bodybuilders vs powerlifters: negative effects of androgen use. JAMA . 1984;;252: 507-513.
Elashoff JD, Jacknow AD, Shain SG, Braunstein GD.  Effect of anabolic-androgenic steroids on muscular strength. Ann Intern Med . 1991;;115:389-393.
Council on Scientific Affairs, American Medical Association.  Drug abuse in athletes: anabolic steroids and human growth hormone. JAMA . 1988;;259:1703-1705.

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Forbes GB, Porta CR, Herr BE, Griggs RC.  Sequence of changes in body composition induced by testosterone and reversal of changes after drug is stopped. JAMA . 1992;;267:397-399.
Council on Scientific Affairs, American Medical Association.  Medical and non-medical uses of anabolic androgenic steroids. JAMA . 1990;;264:2923-2927.
Hurley BF, Jeals DR, Hagerg JM, et al.  High-density lipoprotein cholesterol in bodybuilders vs powerlifters: negative effects of androgen use. JAMA . 1984;;252: 507-513.
Elashoff JD, Jacknow AD, Shain SG, Braunstein GD.  Effect of anabolic-androgenic steroids on muscular strength. Ann Intern Med . 1991;;115:389-393.
Council on Scientific Affairs, American Medical Association.  Drug abuse in athletes: anabolic steroids and human growth hormone. JAMA . 1988;;259:1703-1705.
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To understand the clinical management of acute heart failure syndromes.
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