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May 27, 1992, Vol 267, No. 20 >
ARTICLE | May 27, 1992

Pertussis Vaccines: Title and subTitle BreakSeeking a Better Mousetrap FREE

Eugene D. Shapiro, MD
[+] Author Affiliations

Reprint requests to Department of Pediatrics, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510-8064 (Dr Shapiro).


JAMA. 1992;267(20):2788-2790. doi:10.1001/jama.1992.03480200096032
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References

Immunization against communicable diseases is one of the great successes of modern medicine. Smallpox has been eradicated. In developed countries, diseases such as polio, diphtheria, and tetanus, which once ravaged populations, have been virtually eliminated. Newer vaccines, such as the polysaccharide-protein conjugate vaccines against Haemophilus influenzae type b, are likely to have a similar impact. Work continues on many new vaccines that are developed and produced using sophisticated techniques of modern molecular biology. Already, we are using genetically engineered vaccines against hepatitis B. Why then, in this age of genetic cloning, do we still use a crude, whole-cell vaccine against Bordetella pertussis (a vaccine that essentially is a preparation of killed, whole bacteria) to prevent whooping cough? The excellent study by Onorato et al1 published in this issue of The Journal reminds us of a major reason that we use whole-cell pertussis vaccine: it works!

See also p 2745.

REFERENCES

1 +
Onorato IM, Wassilak SG, Meade B.  Efficacy of whole-cell pertussis vaccine in preschool children in the United States. JAMA . 1992;;267:2745-2749.
2 +
Fine PEM, Clarkson JA.  Reflections on the efficacy of pertussis vaccines. Rev Infect Dis . 1987;;9:866-883.
3 +
Edwards KM, Karzon DT.  Pertussis vaccines. Pediatr Clin North Am . 1990;;37: 549-566.
4 +
Immunization Practices Advisory Committee.  Pertussis vaccination: acellular pertussis vaccine for reinforcing and booster use—supplementary ACIP statement. MMWR . 1992;;41( (RR-1) ):1-10.
5 +
Decker MD, Edwards KM, Steinhoff MC, et al.  Comparison of thirteen acellular pertussis vaccines: adverse reactions. Pediatr Res . 1992;;31:90A.
6 +
Edwards KM, Meade BD, Decker MD, et al.  Comparison of thirteen acellular pertussis vaccines: serologic response. Pediatr Res . 1992;;31:91A.
7 +
Edwards KM, Lawrence E, Wright PF.  Diphtheria, tetanus, and pertussis vaccine: a comparison of the immune response and adverse reactions to conventional and acellular pertussis components. AJDC . 1986;;140:867-871.
8 +
Blumberg DA, Mink CM, Cherry JD, et al.  Comparison of acellular and whole-cell pertussis-component diphtheria-tetanus-pertussis vaccines in infants. J Pediatr . 1991;;119:194-204.
9 +
Kulenkampff M, Schwartzman JS, Wilson J.  Neurological complications of pertussis inoculation. Arch Dis Child . 1974;;49:46-49.
10 +
Department of Health and Social Security. Report of the Committee on Safety of Medicines and Joint Committee on Vaccination and Immunisation . London, England: Her Majesty's Stationery Office; 1981;:1-184.
11 +
Bowie C.  Lessons from the pertussis vaccine court trial. Lancet . 1990;;335:397-399.
12 +
Child Neurology Society.  Ad hoc committee for the Child Neurology Society consensus statement on pertussis immunization and the central nervous system. Ann Neurol . 1991;;29:458-460.
13 +
Wentz KR, Marcuse EK.  Diphtheria-tetanus-pertussis vaccine and serious neurologic illness: an updated review of the epidemiologic evidence. Pediatrics . 1991;;87: 287-297.
14 +
Howson CP, Fineberg HV.  Adverse events following pertussis and rubella vaccines: summary of a report of the Institute of Medicine. JAMA . 1992;;267:392-396.
15 +
Fulginiti VA.  A pertussis vaccine myth dies. AJDC . 1990;;144:860-861.
16 +
Griffith AH.  Permanent brain damage and pertussis vaccination: is the end of the saga in sight? Vaccine . 1989;;7:199-210.
17 +
Golden GS.  Pertussis vaccine and injury to the brain. J Pediatr . 1990;;116:854-861.
18 +
Griffin MR, Ray WA, Mortimer EA, Fenichel GM, Schaffner W.  Risk of seizures and encephalopathy after immunization with the diphtheria-tetanus-pertussis vaccine. JAMA . 1990;;263:1641-1645.
19 +
Cherry JD, Brunell PA, Golden GS, Karzon DT.  Report of the task force on pertussis and pertussis immunization—1988. Pediatrics . 1988;;81( (suppl) ):933-984.
20 +
Clayton EW, Hickson GB.  Compensation under the national childhood vaccine injury act. J Pediatr . 1990;;116:508-513.
21 +
Landwirth J.  Medical-legal aspects of immunization: policy and practices. Pediatr Clin North Am . 1990;;37:771-784.
22 +
Noble GR, Bernier RH, Esber EC, et al.  Acellular and whole-cell pertussis vaccines in Japan: report of a visit by US scientists. JAMA . 1987;;257:1351-1356.
23 +
Baraff LJ, Shields WD, Beckwith L, et al.  Infants and children with convulsions and hypotonic-hyporesponsive episodes following diphtheria-tetanus-pertussis immunization: follow-up evaluation. Pediatrics . 1988;;81:789-794.
24 +
Kato T, Goshima T, Nakajima N, Kaku H, Arimoto Y, Hayashi F.  Protection against pertussis by acellular pertussis vaccines (Takeda, Japan): household contact studies in Kawasaki City, Japan. Acta Paediatr Jpn . 1989;;31:698-701.
25 +
Mortimer EA, Kimura M, Cherry JD, et al.  Protective efficacy of the Takeda acellular pertussis vaccine combined with diphtheria and tetanus toxoids following household exposure of Japanese children. AJDC . 1990;;144:899-904.
26 +
Ad Hoc Group for the Study of Pertussis Vaccines.  Placebo-controlled trial of two acellular pertussis vaccines in Sweden: protective efficacy and adverse events. Lancet . 1988;;1:955-960.
27 +
Storsaeter J, Hallander H, Farrington CP, Olin P, Möllby R, Miller E.  Secondary analyses of the efficacy of two acellular pertussis vaccines in a Swedish phase III trial. Vaccine . 1990;;8:457-461.
28 +
Olin P, Storsaeter J, Romanus V.  The efficacy of acellular pertussis vaccine. JAMA . 1989;;261:560.
29 +
Blackwelder WC, Storsaeter J, Olin P, Hallander HO.  Acellular pertussis vaccine: efficacy and evaluation of clinical case definitions. AJDC . 1991;;145:1285-1289.
30 +
Long SS, Lischner HW, Deforest A, Clark JL.  Serologic evidence of subclinical pertussis in immunized children. Pediatr Infect Dis J . 1990;;9:700-705.
31 +
Halperin SA, Bortolussi R, MacLean D, et al.  Persistence of pertussis in an immunized population: results of the Nova Scotia enhanced pertussis surveillance program. J Pediatr . 1989;;115:686-693.
32 +
Long SS, Welkon CJ, Clark JL.  Widespread silent transmission of pertussis in families: antibody correlates of infection and symptomatology. J Infect Dis . 1990;; 161:480-486.
33 +
Nelson JD.  The changing epidemiology of pertussis in young infants. AJDC . 1978;;132:371-373.
34 +
Mortimer EA Jr.  Pertussis and its prevention: a family affair. J Infect Dis . 1990;; 161:473-479.
35 +
Van Savage J, Decker MD, Edwards KM, Sell SH, Karzon DT.  Natural history of pertussis antibody in the infant and effect on vaccine response. J Infect Dis . 1990;; 161:487-492.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Onorato IM, Wassilak SG, Meade B.  Efficacy of whole-cell pertussis vaccine in preschool children in the United States. JAMA . 1992;;267:2745-2749.
2 +
Fine PEM, Clarkson JA.  Reflections on the efficacy of pertussis vaccines. Rev Infect Dis . 1987;;9:866-883.
3 +
Edwards KM, Karzon DT.  Pertussis vaccines. Pediatr Clin North Am . 1990;;37: 549-566.
4 +
Immunization Practices Advisory Committee.  Pertussis vaccination: acellular pertussis vaccine for reinforcing and booster use—supplementary ACIP statement. MMWR . 1992;;41( (RR-1) ):1-10.
5 +
Decker MD, Edwards KM, Steinhoff MC, et al.  Comparison of thirteen acellular pertussis vaccines: adverse reactions. Pediatr Res . 1992;;31:90A.
6 +
Edwards KM, Meade BD, Decker MD, et al.  Comparison of thirteen acellular pertussis vaccines: serologic response. Pediatr Res . 1992;;31:91A.
7 +
Edwards KM, Lawrence E, Wright PF.  Diphtheria, tetanus, and pertussis vaccine: a comparison of the immune response and adverse reactions to conventional and acellular pertussis components. AJDC . 1986;;140:867-871.
8 +
Blumberg DA, Mink CM, Cherry JD, et al.  Comparison of acellular and whole-cell pertussis-component diphtheria-tetanus-pertussis vaccines in infants. J Pediatr . 1991;;119:194-204.
9 +
Kulenkampff M, Schwartzman JS, Wilson J.  Neurological complications of pertussis inoculation. Arch Dis Child . 1974;;49:46-49.
10 +
Department of Health and Social Security. Report of the Committee on Safety of Medicines and Joint Committee on Vaccination and Immunisation . London, England: Her Majesty's Stationery Office; 1981;:1-184.
11 +
Bowie C.  Lessons from the pertussis vaccine court trial. Lancet . 1990;;335:397-399.
12 +
Child Neurology Society.  Ad hoc committee for the Child Neurology Society consensus statement on pertussis immunization and the central nervous system. Ann Neurol . 1991;;29:458-460.
13 +
Wentz KR, Marcuse EK.  Diphtheria-tetanus-pertussis vaccine and serious neurologic illness: an updated review of the epidemiologic evidence. Pediatrics . 1991;;87: 287-297.
14 +
Howson CP, Fineberg HV.  Adverse events following pertussis and rubella vaccines: summary of a report of the Institute of Medicine. JAMA . 1992;;267:392-396.
15 +
Fulginiti VA.  A pertussis vaccine myth dies. AJDC . 1990;;144:860-861.
16 +
Griffith AH.  Permanent brain damage and pertussis vaccination: is the end of the saga in sight? Vaccine . 1989;;7:199-210.
17 +
Golden GS.  Pertussis vaccine and injury to the brain. J Pediatr . 1990;;116:854-861.
18 +
Griffin MR, Ray WA, Mortimer EA, Fenichel GM, Schaffner W.  Risk of seizures and encephalopathy after immunization with the diphtheria-tetanus-pertussis vaccine. JAMA . 1990;;263:1641-1645.
19 +
Cherry JD, Brunell PA, Golden GS, Karzon DT.  Report of the task force on pertussis and pertussis immunization—1988. Pediatrics . 1988;;81( (suppl) ):933-984.
20 +
Clayton EW, Hickson GB.  Compensation under the national childhood vaccine injury act. J Pediatr . 1990;;116:508-513.
21 +
Landwirth J.  Medical-legal aspects of immunization: policy and practices. Pediatr Clin North Am . 1990;;37:771-784.
22 +
Noble GR, Bernier RH, Esber EC, et al.  Acellular and whole-cell pertussis vaccines in Japan: report of a visit by US scientists. JAMA . 1987;;257:1351-1356.
23 +
Baraff LJ, Shields WD, Beckwith L, et al.  Infants and children with convulsions and hypotonic-hyporesponsive episodes following diphtheria-tetanus-pertussis immunization: follow-up evaluation. Pediatrics . 1988;;81:789-794.
24 +
Kato T, Goshima T, Nakajima N, Kaku H, Arimoto Y, Hayashi F.  Protection against pertussis by acellular pertussis vaccines (Takeda, Japan): household contact studies in Kawasaki City, Japan. Acta Paediatr Jpn . 1989;;31:698-701.
25 +
Mortimer EA, Kimura M, Cherry JD, et al.  Protective efficacy of the Takeda acellular pertussis vaccine combined with diphtheria and tetanus toxoids following household exposure of Japanese children. AJDC . 1990;;144:899-904.
26 +
Ad Hoc Group for the Study of Pertussis Vaccines.  Placebo-controlled trial of two acellular pertussis vaccines in Sweden: protective efficacy and adverse events. Lancet . 1988;;1:955-960.
27 +
Storsaeter J, Hallander H, Farrington CP, Olin P, Möllby R, Miller E.  Secondary analyses of the efficacy of two acellular pertussis vaccines in a Swedish phase III trial. Vaccine . 1990;;8:457-461.
28 +
Olin P, Storsaeter J, Romanus V.  The efficacy of acellular pertussis vaccine. JAMA . 1989;;261:560.
29 +
Blackwelder WC, Storsaeter J, Olin P, Hallander HO.  Acellular pertussis vaccine: efficacy and evaluation of clinical case definitions. AJDC . 1991;;145:1285-1289.
30 +
Long SS, Lischner HW, Deforest A, Clark JL.  Serologic evidence of subclinical pertussis in immunized children. Pediatr Infect Dis J . 1990;;9:700-705.
31 +
Halperin SA, Bortolussi R, MacLean D, et al.  Persistence of pertussis in an immunized population: results of the Nova Scotia enhanced pertussis surveillance program. J Pediatr . 1989;;115:686-693.
32 +
Long SS, Welkon CJ, Clark JL.  Widespread silent transmission of pertussis in families: antibody correlates of infection and symptomatology. J Infect Dis . 1990;; 161:480-486.
33 +
Nelson JD.  The changing epidemiology of pertussis in young infants. AJDC . 1978;;132:371-373.
34 +
Mortimer EA Jr.  Pertussis and its prevention: a family affair. J Infect Dis . 1990;; 161:473-479.
35 +
Van Savage J, Decker MD, Edwards KM, Sell SH, Karzon DT.  Natural history of pertussis antibody in the infant and effect on vaccine response. J Infect Dis . 1990;; 161:487-492.

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