Edited by Drummond Rennie, MD, Deputy Editor (West), and Don Riesenberg, MD, Senior Editor.
To the Editor.— We commend Edelson et al1 on a thoughtful economic analysis of misoprostol, parts of which extend and corroborate our earlier work.2 We agree that the most robust science is produced when different investigators approach a question in different ways and come to similar conclusions, which is indeed the case with portions of our two studies.3There is one published, randomized, controlled clinical trial of misoprostol for prophylaxis of gastric ulcer, in which all patients had multiple endoscopies.4 In this 3-month trial, all of the several hundred patients with osteoarthritis had abdominal pain attributed to use of nonsteroidal anti-inflammatory drugs (NSAIDs) (but no gastric ulcer on endoscopy on entry to the study). The statements of Edelson et al about our interpretation of these data are incorrect. We calculated the relative risk of gastric ulcer in patients receiving misoprostol compared with the control group to
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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