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January 16, 1991, Vol 265, No. 3 >
ARTICLE | January 16, 1991

Prevention of Malaria FREE

Stephen L. Hoffman, MD, DTMH
[+] Author Affiliations

The opinions and assertions herein are those of the author and are not to be construed as official or as reflecting the views of the US Navy Department or the naval service at large.

Reprint requests to Infectious Diseases Department, Naval Medical Research Institute Annex, 12300 Washington Ave, Rockville, MD 20852 (Dr Hoffman).


JAMA. 1991;265(3):398-399. doi:10.1001/jama.1991.03460030104039
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References

In 1990, the World Health Organization estimated that 2.1 billion people live in malarious areas of the world and that 270 million people develop new malaria infections each year.1 Although transmission of malaria was interrupted in the United States in the early 1950s, it is still a major concern to the 7 million Americans who visit countries with malaria every year.

Several years ago I was asked to consult on a patient with cerebral malaria. The patient had visited Kenya (East Africa) on safari several weeks earlier and had not taken chemoprophylaxis. Eight days before I saw him he developed fever and headache, and 2 days later he presented to an emergency department with the chief complaint, "I have malaria." The malaria smear was reported as negative (review revealed low parasitemia). The physician prescribed an antipyretic and follow-up in 2 days if his condition did not improve. Three days

REFERENCES

1 +
 Tropical diseases in media spotlight . TDR News 1990;;31:3.
2 +
Greenberg AE, Lobel HO.  Mortality from Plasmodium falciparum malaria in travelers from the United States, 1959 to 1987 . Ann Intern Med. 1990;;113:326-327.
3 +
Lackritz EM, Lobel HO, Howell BJ, Bloland P, Campbell CC.  Imported Plasmodium falciparum malaria in American travelers to Africa: implications for prevention strategies . JAMA . 1991;;265:383-385.
4 +
Moran JS, Bernard KW.  The spread of chloroquine-resistant malaria in Africa . JAMA . 1989;;262:245-248.
5 +
Lobel HO, Bernard KW, Williams SL, Hightower AW, Patchen LC, Campbell CC.  Effectiveness and tolerance of long-term malaria prophylaxis with mefloquine: need for a better dosing regimen . JAMA . 1991;;265:361-364.
6 +
Trenholme GM, Williams RL, Desjardins RE, et al.  Mefloquine (WR 142,490) in the treatment of human malaria . Science . 1975;;190:792-794.
7 +
Smrkovski LL, Buck RL, Alcantara AK, Rodriguez CS, Uylangco CU.  In vitro mefloquine-resistant Plasmodium falciparum from the Philippines . Lancet . 1982;;2:722.
8 +
Hoffman SL, Dimpudus AJ, Campbell JR, et al.  RII and RIII type resistance of Plasmodium falciparum to combination of mefloquine and sulfadoxine/primethamine in Indonesia . Lancet . 1985;;2:1039-1040.
9 +
Beaudreau EF, Webster HK, Pavanand K, Thosingha L.  Type II mefloquine resistance in Thailand . Lancet . 1982;;2:1335.
10 +
Bygbjerg IC, Schapira A, Flachs H, Gomme G.  Mefloquine resistance of falciparum malaria from Tanzania enhanced by treatment . Lancet . 1981;;1:21-26.
11 +
Centers for Disease Control.  Revised dosing regimen for malaria prophylaxis with mefloquine . MMWR . 1990;;39:630.
12 +
Steffen R, Heusser R, Machler R, et al.  Malaria chemoprophylaxis among European tourists in tropical Africa: use, adverse reactions and efficacy . Bull World Health Organ . 1990;;68:313-322.
13 +
AlvingAS, Craig BJr, Pullman TN, Whorton CM, Jones RJr,  Eichelberger L. Procedures used at Stateville Penitentiary for the testing of potential antimalarial agents . J Clin Invest. 1948;;27:1-5.
14 +
Miller LH, Howard RJ, Carter R, Good MF, Nussenzweig V, Nussenzweig R.  Research toward malaria vaccines . Science . 1986;;234:1349-1356.
15 +
Marwick C.  Long struggle continues to find new weapons against an old foe—the malaria parasite . JAMA . 1990;;263:2718.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
 Tropical diseases in media spotlight . TDR News 1990;;31:3.
2 +
Greenberg AE, Lobel HO.  Mortality from Plasmodium falciparum malaria in travelers from the United States, 1959 to 1987 . Ann Intern Med. 1990;;113:326-327.
3 +
Lackritz EM, Lobel HO, Howell BJ, Bloland P, Campbell CC.  Imported Plasmodium falciparum malaria in American travelers to Africa: implications for prevention strategies . JAMA . 1991;;265:383-385.
4 +
Moran JS, Bernard KW.  The spread of chloroquine-resistant malaria in Africa . JAMA . 1989;;262:245-248.
5 +
Lobel HO, Bernard KW, Williams SL, Hightower AW, Patchen LC, Campbell CC.  Effectiveness and tolerance of long-term malaria prophylaxis with mefloquine: need for a better dosing regimen . JAMA . 1991;;265:361-364.
6 +
Trenholme GM, Williams RL, Desjardins RE, et al.  Mefloquine (WR 142,490) in the treatment of human malaria . Science . 1975;;190:792-794.
7 +
Smrkovski LL, Buck RL, Alcantara AK, Rodriguez CS, Uylangco CU.  In vitro mefloquine-resistant Plasmodium falciparum from the Philippines . Lancet . 1982;;2:722.
8 +
Hoffman SL, Dimpudus AJ, Campbell JR, et al.  RII and RIII type resistance of Plasmodium falciparum to combination of mefloquine and sulfadoxine/primethamine in Indonesia . Lancet . 1985;;2:1039-1040.
9 +
Beaudreau EF, Webster HK, Pavanand K, Thosingha L.  Type II mefloquine resistance in Thailand . Lancet . 1982;;2:1335.
10 +
Bygbjerg IC, Schapira A, Flachs H, Gomme G.  Mefloquine resistance of falciparum malaria from Tanzania enhanced by treatment . Lancet . 1981;;1:21-26.
11 +
Centers for Disease Control.  Revised dosing regimen for malaria prophylaxis with mefloquine . MMWR . 1990;;39:630.
12 +
Steffen R, Heusser R, Machler R, et al.  Malaria chemoprophylaxis among European tourists in tropical Africa: use, adverse reactions and efficacy . Bull World Health Organ . 1990;;68:313-322.
13 +
AlvingAS, Craig BJr, Pullman TN, Whorton CM, Jones RJr,  Eichelberger L. Procedures used at Stateville Penitentiary for the testing of potential antimalarial agents . J Clin Invest. 1948;;27:1-5.
14 +
Miller LH, Howard RJ, Carter R, Good MF, Nussenzweig V, Nussenzweig R.  Research toward malaria vaccines . Science . 1986;;234:1349-1356.
15 +
Marwick C.  Long struggle continues to find new weapons against an old foe—the malaria parasite . JAMA . 1990;;263:2718.

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