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ARTICLE |

Nephrology FREE

Shaul G. Massry, MD
JAMA. 1991;265(23):3135-3137. doi:10.1001/jama.1991.03460230085023
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Research directed at further understanding the factors that contribute to the progression of renal failure dominates the field of nephrology.1 Major advances have occurred, and it has become well accepted that hypertension in patients with renal insufficiency of any origin is a major risk factor. Strict control of hypertension can delay or prevent the progression of renal insufficiency to endstage renal failure.

The role of dietary protein restriction in preventing the progression of renal failure has not yet been established. Although the results of many investigations support a beneficial effect of protein restriction, its wide-scale application should await definite documentation. The National Institute of Diabetes and Digestive and Kidney Diseases is currently sponsoring a multicenter controlled study of the effects of several dietary protein regimens on the progression of renal failure in patients with varying degrees of renal insufficiency. The study will be completed in 2 years, and the

REFERENCES

 Nutritional and pharmacological strategies in chronic renal failure . In: Albertazzi A, Cappelli P, Del Ross G, DiPaola B, Evangelista M, Palmieri P, eds. Contribution to Nephrology . Basel, Switzerland: Karger; 1989;:1-290.
Lee-Huang S.  Cloning and expression of human erythropoietin: CDNA  in E. coli. Proc NatlAcadSci U S A. 1984;;81:2708-2712.
 Erythropoietin . Lancet . 1987;;1:781-782. Editorial.
Schaefer RM, Horl WH, Massry SG.  Treatment of renal anemia with recombinant human erythropoietin . Am J Nephrol. 1989;;9:353-362.
Eshbach JW.  Recombinant human erythropoietin: overall approach to the anemia of chronic renal failure . Am J Kidney Dis. 1989;;14( (suppl 1) ):S1-S25.
Wolfson M, Bennette M.  Management guidelines for the treatment of renal anemia . Am J Nephrol. 1990;;10( (suppl 2) ):S1-S52.
Berson JA, Yalow RS.  Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia, and bronchogenic carcinoma . Science . 1960;;154:907-909.
Massry SG.  Is parathyroid hormone a uremic toxin? Nephron. 1977;;19:125-130.
Massry SG.  Parathyroid hormone as a uremic toxin . In: Massry SG, Glassock JR, eds. Textbook of Nephrology . Baltimore, Md: Williams & Wilkins; 1989;:1126-1144.
Fadda GZ, Hajjar SM, Perna AF, Zhou X-J, Lipson LG, Massry SG.  On the mechanism of impaired insulin secretion in chronic renal failure . J Clin Invest. 1991;;87:225-261.
Alexiewicz JM, Gacion Z, Klinger M, Linker-Israeli M, Pitts TO, Massry SG.  Evidence for impaired T-cell function in hemodialysis: a potential role for secondary hyperparathyroidism . Am J Nephrol. 1990;;10:495-501.
Khan BD.  Cyclosporine . In: Massry SG, Glassock JR, eds. Textbook of Nephrology . Baltimore, Md: Williams & Wilkins; 1989;:1487-1499.
Strom TB, Leichman A.  Polyclonal and monoclonal antilymphocyte antibodies . In: Massry SG, Glassock JR, eds. Textbook of Nephrology . Baltimore, Md: Williams and Wilkins; 1989;:1499-1501.
Todo S, Fung JJ, Starzl TE, et al.  Liver, kidney and thoracic organ tranplantation under FK 506 . Ann Surg. 1990;;212:295-307.
Kourilsky P, Claverie J-M.  MAC-antigen interaction: what does T-cells see? Adv Immunol. 1989;;45:107-193.
Altman A, Coggeshall KM, Mustelin T.  Molecular events mediating T-cell activation . Adv Immunol. 1990;;48:227-360.
VanRood JJ, Class FHJ.  The influence of allogenic cells on the human T and B cell repertoire . Science . 1990;;248:1388-1393.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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 Nutritional and pharmacological strategies in chronic renal failure . In: Albertazzi A, Cappelli P, Del Ross G, DiPaola B, Evangelista M, Palmieri P, eds. Contribution to Nephrology . Basel, Switzerland: Karger; 1989;:1-290.
Lee-Huang S.  Cloning and expression of human erythropoietin: CDNA  in E. coli. Proc NatlAcadSci U S A. 1984;;81:2708-2712.
 Erythropoietin . Lancet . 1987;;1:781-782. Editorial.
Schaefer RM, Horl WH, Massry SG.  Treatment of renal anemia with recombinant human erythropoietin . Am J Nephrol. 1989;;9:353-362.
Eshbach JW.  Recombinant human erythropoietin: overall approach to the anemia of chronic renal failure . Am J Kidney Dis. 1989;;14( (suppl 1) ):S1-S25.
Wolfson M, Bennette M.  Management guidelines for the treatment of renal anemia . Am J Nephrol. 1990;;10( (suppl 2) ):S1-S52.
Berson JA, Yalow RS.  Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia, and bronchogenic carcinoma . Science . 1960;;154:907-909.
Massry SG.  Is parathyroid hormone a uremic toxin? Nephron. 1977;;19:125-130.
Massry SG.  Parathyroid hormone as a uremic toxin . In: Massry SG, Glassock JR, eds. Textbook of Nephrology . Baltimore, Md: Williams & Wilkins; 1989;:1126-1144.
Fadda GZ, Hajjar SM, Perna AF, Zhou X-J, Lipson LG, Massry SG.  On the mechanism of impaired insulin secretion in chronic renal failure . J Clin Invest. 1991;;87:225-261.
Alexiewicz JM, Gacion Z, Klinger M, Linker-Israeli M, Pitts TO, Massry SG.  Evidence for impaired T-cell function in hemodialysis: a potential role for secondary hyperparathyroidism . Am J Nephrol. 1990;;10:495-501.
Khan BD.  Cyclosporine . In: Massry SG, Glassock JR, eds. Textbook of Nephrology . Baltimore, Md: Williams & Wilkins; 1989;:1487-1499.
Strom TB, Leichman A.  Polyclonal and monoclonal antilymphocyte antibodies . In: Massry SG, Glassock JR, eds. Textbook of Nephrology . Baltimore, Md: Williams and Wilkins; 1989;:1499-1501.
Todo S, Fung JJ, Starzl TE, et al.  Liver, kidney and thoracic organ tranplantation under FK 506 . Ann Surg. 1990;;212:295-307.
Kourilsky P, Claverie J-M.  MAC-antigen interaction: what does T-cells see? Adv Immunol. 1989;;45:107-193.
Altman A, Coggeshall KM, Mustelin T.  Molecular events mediating T-cell activation . Adv Immunol. 1990;;48:227-360.
VanRood JJ, Class FHJ.  The influence of allogenic cells on the human T and B cell repertoire . Science . 1990;;248:1388-1393.
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To understand the clinical management of acute heart failure syndromes.
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