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ARTICLE |

Maternal Use of Ginseng and Neonatal Androgenization FREE

Dennis V. C. Awang, PhD, FCIC
JAMA. 1991;265(14):1828-1828. doi:10.1001/jama.1991.03460140056022
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To the Editor.—  The letter by Koren et al,1 which reported neonatal androgenization attributed to maternal use of ginseng, demands attention by consumers of herbal products and health professionals, as well as by those charged with regulating commercial plant products. The case emphasizes our inherent ignorance as to the botanical identity of such products, as well as the need for sound botanical and chemical information in any consideration of the adverse effects of herbal medicines.The widely cited statement by Siegel2 that "the term 'ginseng' can refer to any of 22 related plants" is thoroughly misleading and probably refers to the number of plant species other than Panax (22 in 12 genera of seven families) that Hu3 has identified as producing "seng"—the fleshy underground portion of many plants used as tonics by practitioners of traditional Chinese medicine. There appear to be three to six recognized species of

REFERENCES

Koren G, Randor S, Martin S, Danneman D.  Maternal ginseng use associated with neonatal androgenization . JAMA . 1990;;264:2866.
Siegel RK.  Ginseng abuse syndrome . JAMA . 1979;; 241:1614-1615.
Hu SY.  The genus Panax (ginseng) in Chinese medicine . Econ Botany . 1976;;30:11-28.
Phillipson JD, Anderson LA.  Ginseng—quality, safety and efficacy? Pharm J. 1984;;232:161-165.
Liberti LE, Der Marderosian A.  Evaluation of commercial ginseng products . J Pharm Sci. 1978;;67:1487-1489.
Baranov AL.  Medicinal uses of ginseng and related plants in the Soviet Union: recent trends in the Soviet literature . J Ethnopharmacol. 1982;;6:339-353.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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Koren G, Randor S, Martin S, Danneman D.  Maternal ginseng use associated with neonatal androgenization . JAMA . 1990;;264:2866.
Siegel RK.  Ginseng abuse syndrome . JAMA . 1979;; 241:1614-1615.
Hu SY.  The genus Panax (ginseng) in Chinese medicine . Econ Botany . 1976;;30:11-28.
Phillipson JD, Anderson LA.  Ginseng—quality, safety and efficacy? Pharm J. 1984;;232:161-165.
Liberti LE, Der Marderosian A.  Evaluation of commercial ginseng products . J Pharm Sci. 1978;;67:1487-1489.
Baranov AL.  Medicinal uses of ginseng and related plants in the Soviet Union: recent trends in the Soviet literature . J Ethnopharmacol. 1982;;6:339-353.
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