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How to Evaluate Drugs: Title and subTitle BreakCost-effectiveness Analysis FREE

J.Robert Beck, MD
[+] Author Affiliations

The author consults for Pharmacon International, a consulting firm that offers decision support services to the pharmaceutical industry.

Reprint requests to Biomedical Information Communication Center, Oregon Health Sciences University, 3181 SW Sam Jackson Park Rd, Portland, OR 97201-3098 (Dr Beck).


JAMA. 1990;264(1):83-84. doi:10.1001/jama.1990.03450010087037
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The merchandisers of new pharmaceuticals have three principal features to consider when promoting a new drug: (1) Is it more effective than a competitor against the condition being treated? (2) Is it less costly? (3) Does it exhibit fewer side effects? With the costs of drug development, approval, and marketing continually increasing,1 it is rare to find a new medication that is less expensive than its predecessors. Advertisements in this and similar journals trumpet increased efficacy as the easiest concept to grasp in choosing among new drugs. Unfortunately for the manufacturers, not all new preparations can demonstrate increased potency, enhanced bioavailability, or better clinical results. In some recent cases, fewer adverse reactions are the distinguishing features of newer products.

How do you sell a medication that might be more costly, just as effective, and have fewer side effects? Cost-effectiveness analysis offers an answer. This technology compares the health effects

REFERENCES

SombergJC.  Drug development costs . J Clin Pharmacol. 1987;;27:335.
Weinstein MC, Stason WB.  Allocation of resources to manage hypertension . N Engl J Med. 1977;;296:732-739.
Kinosian BP, Eisenberg JM.  Cutting into cholesterol: cost-effective alternatives for treating hypercholesterolemia . JAMA . 1988;;259:2249-2254.
Edelson JT, Tosteson ANA, Sax P.  Cost-effectiveness of misoprostol for prophylaxis against nonsteroidal anti-inflammatory drug—induced gastrointestinal tract bleeding . JAMA .1990;;264:41-47.
Hillman AL, Bloom BS.  Economic effects of prophylactic use of misoprostol to prevent gastric ulcer in patients taking nonsteroidal anti-inflammatory drugs . Arch Intern Med. 1989;;149:2061-2065.
Weinstein MC.  Economic analysis of medical practices and technologies . Med Decis Making . 1981;;1:309-330.

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SombergJC.  Drug development costs . J Clin Pharmacol. 1987;;27:335.
Weinstein MC, Stason WB.  Allocation of resources to manage hypertension . N Engl J Med. 1977;;296:732-739.
Kinosian BP, Eisenberg JM.  Cutting into cholesterol: cost-effective alternatives for treating hypercholesterolemia . JAMA . 1988;;259:2249-2254.
Edelson JT, Tosteson ANA, Sax P.  Cost-effectiveness of misoprostol for prophylaxis against nonsteroidal anti-inflammatory drug—induced gastrointestinal tract bleeding . JAMA .1990;;264:41-47.
Hillman AL, Bloom BS.  Economic effects of prophylactic use of misoprostol to prevent gastric ulcer in patients taking nonsteroidal anti-inflammatory drugs . Arch Intern Med. 1989;;149:2061-2065.
Weinstein MC.  Economic analysis of medical practices and technologies . Med Decis Making . 1981;;1:309-330.
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