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August 22, 1990, Vol 264, No. 8 >
ARTICLE | August 22, 1990

Bovine Somatotropin Supplementation of Dairy Cows: Title and subTitle BreakIs the Milk Safe? FREE

William H. Daughaday, MD; David M. Barbano, PhD
[+] Author Affiliations

Reprint requests to Cornell University Institute of Food Science, Stocking Hall, Ithaca, NY 14853-7201 (Dr Barbano).


JAMA. 1990;264(8):1003-1005. doi:10.1001/jama.1990.03450080089037
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References

Complex, biologically active proteins (eg, enzymes and hormones) can be manufactured safely and cost-effectively through applications of biotechnology. Some of these proteins (eg, human insulin, human somatotropin, rennet for cheese manufacture) are currently approved for medical or food processing applications. Bovine somatotropin (bST) for lactating dairy cattle is another product that can be produced via biotechnology and may allow dairy farmers to produce milk at a lower cost. In 1985, based on an evaluation of toxicological data, the Food and Drug Administration concluded that milk and meat from bST-supplemented cows was safe and wholesome. The Food and Drug Administration has authorized the use of milk and meat from bST-supplemented cows in the commercial food supply. Its evaluation of the impact of bST supplementation on the long-term health of dairy cattle is near completion, and bST may be approved for commercial use in early 1991.

(JAMA. 1990;264:1003-1005)

REFERENCES

1 +
Wallis M.  Species specificity and structure-function relationships of growth hormone . In: Heap RG, Prosser CG, Lamming GE, eds. Biotechnology in Growth Regulation . Stoneham, Mass: Butterworths; 1989;:3-14.
2 +
Daughaday WH, Rotwein P.  Insulin-like growth factors I and II: peptide, mRNA and gene structures, serum and tissue concentrations . Endocr Rev . 1989;;10:69-91.
3 +
Bauman DE, Eppart PJ, DeGeeter MJ, Lanza GM.  Responses of high-producing dairy cows to long-term treatment with pituitary somatotropin and recombinant somatotropin . J Dairy Sci . 1985;; 68:1352-1362.
4 +
Knobil E, Greep RO.  The physiology of somatotropin with particular reference to its action in the rhesus monkey and the species specificity problem . Recent Prog Horm Res . 1959;;15:1-69.
5 +
Raben MS.  Human growth hormone . Recent Prog Horm Res . 1959;;15:71-114.
6 +
Li CH, Liu WK.  Human pituitary growth hormone . Experientia . 1964;;20:169-240.
7 +
Barbano DM, DellaValle, ME.  Seasonal variation in milk solids components in various regions of the U.S . J Dairy Sci . 1985;;68( (suppl 1) ):71.
8 +
Barbano DM.  Impact of seasonal variation in milk composition on cheese yield and composition . Dairy Field . 1987;;170( (10) ):46-50.
9 +
Barbano DM, Lynch JM, Bauman DE, Hartnell GF.  Influence on sometribove (recombinant methionyl bovine somatotropin) on general milk composition . J Dairy Sci . 1988;;71( (suppl 1) ):101.
10 +
Lynch JM, Barbano DM, Bauman DE, Hartnell GF.  Influence of sometribove (recombinant methionyl bovine somatotropin) on protein and fatty acid composition of milk . J Dairy Sci . 1988;;71( (suppl 1) ):100.
11 +
Lynch JM, Barbano DM, Bauman DE, Hartnell GF.  Influence of sometribove (recombinant methionyl bovine somatotropin) on thermal properties and cholesterol content of milk fat . J Dairy Sci . 1989;;72( (suppl 1) ):153.
12 +
Baer RJ, Tieszen KM, Schingoethe DJ, et al.  Composition and flavor of milk produced by cows injected with recombinant bovine somatotropin . J Dairy Sci . 1989;;72:1424-1434.
13 +
Bauman DE, Hard DL, Crooker BA, et al.  Long-term evaluation of a prolonged-release formulation of N-methionyl bovine somatotropin in lactating dairy cows . J Dairy Sci . 1989;;72:642-651.
14 +
Lynch JM, Barbano DM, Bauman DE, Houghton GE, Hartnell GF.  Influence of sometribove (recombinant methionyl bovine somatotropin) on milk flavor and starter culture growth in milk . J Dairy Sci . 1989;;72( (suppl 1) ):187.
15 +
Mohammed ME, Johnson HD.  Effect of growth hormone on milk yields and related physiological functions of holstein cows exposed to heat stress . J Dairy Sci . 1985;;68:1123-1133.
16 +
Torkelson AR, Dwyer KA, Rogan GJ, Ryan RL.  Radioimmunoassay of somatotropin in milk from cows administered recombinant bovine somatotropin . J Dairy Sci . 1987;;70( (suppl 1) ):146.
17 +
Marcek JM, Seaman WJ, Nappier JL.  Effects of repeated high dose administration of recombinant bovine somatotropin in lactating dairy cows . Vet Hum Toxicol . 1989;;31:455-459.
18 +
Akers RM.  Lactogenic hormones: binding sites, mammary growth, secretory cell differentiation, and milk biosynthesis in ruminants . J Dairy Sci . 1985;;68:501-519.
19 +
Bennett HP, McMartin C.  Peptide hormones and their analogues: distribution, clearance from the circulation, and inactivation in vivo . Pharmacol Rev . 1979;;30:247-292.
20 +
Johnson V, Maack T.  Renal extraction, filtration, absorption, and catabolism of somatotropin . Am J Physiol . 1977;; 233:F185-F196.
21 +
Davis SR, Gluckman PD, Hart IC, Henderson HV.  Effects of injecting growth hormone or thyroxine on milk production and blood plasma concentrations of insulin-like growth factors I and II in dairy cows . J Endocrinol Ltd . 1987;;114:17-24.
22 +
Torkelson AR, Lanza GM, Birmingham BK, et al.  Concentrations of insulin-like growth factor-I (IGF-I) in bovine milk: effect of herd, stage of lactation and sometribove, USAN (recombinant methionyl bovine somatotropin) . J Dairy Sci . 1988;; 71( (suppl 1) ):169.
23 +
Baxter RC, Zaltsman Z, Turtle JR.  Immunoreactive somatomedin C/insulin-like growth factor-I and its binding protein in human milk . J Clin Endocrinol Metab . 1984;;58:955-959.
24 +
Corps AN, Brown KD, Rees LH, Carr J, Prosser CG.  The insulin-like growth factor-I in human milk increases between early and full lactation . J Clin Endocrinol Metab . 1988;;67:25-29.
25 +
Miller MA, Hildebrandt JR, White TC, Hammond BG, Madsen KS, Collier RJ.  Determination of insulin-like growth factor-I (IGF-I) concentrations in raw, pasteurized, and heat-treated milk . J Dairy Sci . 1989;;72( (suppl 1) ):186-187.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Wallis M.  Species specificity and structure-function relationships of growth hormone . In: Heap RG, Prosser CG, Lamming GE, eds. Biotechnology in Growth Regulation . Stoneham, Mass: Butterworths; 1989;:3-14.
2 +
Daughaday WH, Rotwein P.  Insulin-like growth factors I and II: peptide, mRNA and gene structures, serum and tissue concentrations . Endocr Rev . 1989;;10:69-91.
3 +
Bauman DE, Eppart PJ, DeGeeter MJ, Lanza GM.  Responses of high-producing dairy cows to long-term treatment with pituitary somatotropin and recombinant somatotropin . J Dairy Sci . 1985;; 68:1352-1362.
4 +
Knobil E, Greep RO.  The physiology of somatotropin with particular reference to its action in the rhesus monkey and the species specificity problem . Recent Prog Horm Res . 1959;;15:1-69.
5 +
Raben MS.  Human growth hormone . Recent Prog Horm Res . 1959;;15:71-114.
6 +
Li CH, Liu WK.  Human pituitary growth hormone . Experientia . 1964;;20:169-240.
7 +
Barbano DM, DellaValle, ME.  Seasonal variation in milk solids components in various regions of the U.S . J Dairy Sci . 1985;;68( (suppl 1) ):71.
8 +
Barbano DM.  Impact of seasonal variation in milk composition on cheese yield and composition . Dairy Field . 1987;;170( (10) ):46-50.
9 +
Barbano DM, Lynch JM, Bauman DE, Hartnell GF.  Influence on sometribove (recombinant methionyl bovine somatotropin) on general milk composition . J Dairy Sci . 1988;;71( (suppl 1) ):101.
10 +
Lynch JM, Barbano DM, Bauman DE, Hartnell GF.  Influence of sometribove (recombinant methionyl bovine somatotropin) on protein and fatty acid composition of milk . J Dairy Sci . 1988;;71( (suppl 1) ):100.
11 +
Lynch JM, Barbano DM, Bauman DE, Hartnell GF.  Influence of sometribove (recombinant methionyl bovine somatotropin) on thermal properties and cholesterol content of milk fat . J Dairy Sci . 1989;;72( (suppl 1) ):153.
12 +
Baer RJ, Tieszen KM, Schingoethe DJ, et al.  Composition and flavor of milk produced by cows injected with recombinant bovine somatotropin . J Dairy Sci . 1989;;72:1424-1434.
13 +
Bauman DE, Hard DL, Crooker BA, et al.  Long-term evaluation of a prolonged-release formulation of N-methionyl bovine somatotropin in lactating dairy cows . J Dairy Sci . 1989;;72:642-651.
14 +
Lynch JM, Barbano DM, Bauman DE, Houghton GE, Hartnell GF.  Influence of sometribove (recombinant methionyl bovine somatotropin) on milk flavor and starter culture growth in milk . J Dairy Sci . 1989;;72( (suppl 1) ):187.
15 +
Mohammed ME, Johnson HD.  Effect of growth hormone on milk yields and related physiological functions of holstein cows exposed to heat stress . J Dairy Sci . 1985;;68:1123-1133.
16 +
Torkelson AR, Dwyer KA, Rogan GJ, Ryan RL.  Radioimmunoassay of somatotropin in milk from cows administered recombinant bovine somatotropin . J Dairy Sci . 1987;;70( (suppl 1) ):146.
17 +
Marcek JM, Seaman WJ, Nappier JL.  Effects of repeated high dose administration of recombinant bovine somatotropin in lactating dairy cows . Vet Hum Toxicol . 1989;;31:455-459.
18 +
Akers RM.  Lactogenic hormones: binding sites, mammary growth, secretory cell differentiation, and milk biosynthesis in ruminants . J Dairy Sci . 1985;;68:501-519.
19 +
Bennett HP, McMartin C.  Peptide hormones and their analogues: distribution, clearance from the circulation, and inactivation in vivo . Pharmacol Rev . 1979;;30:247-292.
20 +
Johnson V, Maack T.  Renal extraction, filtration, absorption, and catabolism of somatotropin . Am J Physiol . 1977;; 233:F185-F196.
21 +
Davis SR, Gluckman PD, Hart IC, Henderson HV.  Effects of injecting growth hormone or thyroxine on milk production and blood plasma concentrations of insulin-like growth factors I and II in dairy cows . J Endocrinol Ltd . 1987;;114:17-24.
22 +
Torkelson AR, Lanza GM, Birmingham BK, et al.  Concentrations of insulin-like growth factor-I (IGF-I) in bovine milk: effect of herd, stage of lactation and sometribove, USAN (recombinant methionyl bovine somatotropin) . J Dairy Sci . 1988;; 71( (suppl 1) ):169.
23 +
Baxter RC, Zaltsman Z, Turtle JR.  Immunoreactive somatomedin C/insulin-like growth factor-I and its binding protein in human milk . J Clin Endocrinol Metab . 1984;;58:955-959.
24 +
Corps AN, Brown KD, Rees LH, Carr J, Prosser CG.  The insulin-like growth factor-I in human milk increases between early and full lactation . J Clin Endocrinol Metab . 1988;;67:25-29.
25 +
Miller MA, Hildebrandt JR, White TC, Hammond BG, Madsen KS, Collier RJ.  Determination of insulin-like growth factor-I (IGF-I) concentrations in raw, pasteurized, and heat-treated milk . J Dairy Sci . 1989;;72( (suppl 1) ):186-187.

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