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Intradermal vs Intramuscular Hepatitis B Vaccinations-Reply FREE

Jessica Anne Clarke, MD, PhD; F. Blaine Hollinger, MD
JAMA. 1990;264(2):182-182. doi:10.1001/jama.1990.03450020033014
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In Reply.—  We applaud the well-designed study by Wiström et al that demonstrates that low-dose ID inoculation of adults with three 2-μg doses of a recombinant hepatitis B vaccine (Recombivax-HB, Merck Sharp & Dohme) results in lower seroconversion rates and reduced levels of antibody to HBsAg compared with three 10-μg IM injections of the same product.These results are not unexpected. There is a positive correlation between dose and immune response regardless of the type of product used.1 In our ID study we were able to use the more immunogenic plasma-derived Hepta

REFERENCES

Troisi CL, Hollinger FB.  Hepatitis B vaccines . In: Popper H, Schaffner F, eds. Progress in Liver Diseases . Philadelphia, Pa: WB Saunders Co; 1990;;9:405-442.
Hollinger FB, Troisi CL, Pepe PE.  Anti-HBs responses to vaccination with a human hepatitis B vaccine made by recombinant DNA technology in yeast . J Infect Dis. 1986;;153:156-159.
Clarke JA, Hollinger FB, Lewis E, et al.  Intradermal inoculation with Heptavax-B: immune response and histological evaluation of injection sites . JAMA. 1989;;262:2567-2571.
Milch DR, Thornton GB, Neurath AR, et al.  Enhanced immunogenicity of the pre-S region of the hepatitis B surface antigen . Science. 1985;;228:1195-1199.

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Troisi CL, Hollinger FB.  Hepatitis B vaccines . In: Popper H, Schaffner F, eds. Progress in Liver Diseases . Philadelphia, Pa: WB Saunders Co; 1990;;9:405-442.
Hollinger FB, Troisi CL, Pepe PE.  Anti-HBs responses to vaccination with a human hepatitis B vaccine made by recombinant DNA technology in yeast . J Infect Dis. 1986;;153:156-159.
Clarke JA, Hollinger FB, Lewis E, et al.  Intradermal inoculation with Heptavax-B: immune response and histological evaluation of injection sites . JAMA. 1989;;262:2567-2571.
Milch DR, Thornton GB, Neurath AR, et al.  Enhanced immunogenicity of the pre-S region of the hepatitis B surface antigen . Science. 1985;;228:1195-1199.
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