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ARTICLE |

Nebulizer Bronchitis Induced by Bacteriostatic Saline FREE

Ronald D. Reynolds, MD
JAMA. 1990;264(1):35-35. doi:10.1001/jama.1990.03450010039017
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To the Editor.—  I wish to report a complication of hand-held nebulizer therapy. Inappropriate selection of bronchodilator diluent may cause bronchitis and hemoptysis.

Report of a Case.—  A 64-year-old nonsmoking man has moderately severe chronic obstructive pulmonary disease of 5 years' duration and is maintained on a regimen of oral theophylline, metered-dose inhaled albuterol and triamcinolone, hydrochlorothiazide for cor pulmonale, and oxygen (as required) for dyspnea. He benefits from use of a home, hand-held albuterol nebulizer during periods of worsening dyspnea.On three separate occasions, he has had episodes of significant hemoptysis. Complete evaluation during the first two of these episodes revealed only an unexpectedly severe bronchitis seen at bronchoscopy. During his most recent episode, his wife noted that the only time he had hemoptysis was after he had used his hand-held nebulizer four times a day for at least a week and a half.Close questioning about technique

REFERENCES

Wilson JP, Solimando DA Jr, Edwards MS.  Parenteral benzyl alcohol—induced hypersensitivity reaction . Drug Intell Clin Pharm. 1986;;20:689-691.
American Academy of Pediatrics, Committee on Fetus and Newborn.  Benzyl alcohol: toxic agent in neonatal units . Pediatrics. 1983;;72:356-358.
Duncan D, Jarvis WH.  A comparison of the actions on nerve fibers of certain anesthetic mixtures and substances in oil . Anesthesiology. 1943;;4:465-474.
Hahn AF, Feasby TE, Gilbert JJ.  Paraparesis following intrathecal chemotherapy . Neurology. 1983;;33:1032-1038.
Rumiantsev GI, Novikov SM, Fursova TN, Kochetkova TA, Ivanov IuV.  Experimental study of the toxic properties of phenylethyl alcohol and phenylethyl acetate [in Russian] . Gig Sanit. 1987;;10:83-84.

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Wilson JP, Solimando DA Jr, Edwards MS.  Parenteral benzyl alcohol—induced hypersensitivity reaction . Drug Intell Clin Pharm. 1986;;20:689-691.
American Academy of Pediatrics, Committee on Fetus and Newborn.  Benzyl alcohol: toxic agent in neonatal units . Pediatrics. 1983;;72:356-358.
Duncan D, Jarvis WH.  A comparison of the actions on nerve fibers of certain anesthetic mixtures and substances in oil . Anesthesiology. 1943;;4:465-474.
Hahn AF, Feasby TE, Gilbert JJ.  Paraparesis following intrathecal chemotherapy . Neurology. 1983;;33:1032-1038.
Rumiantsev GI, Novikov SM, Fursova TN, Kochetkova TA, Ivanov IuV.  Experimental study of the toxic properties of phenylethyl alcohol and phenylethyl acetate [in Russian] . Gig Sanit. 1987;;10:83-84.
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