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Conflicts of Interest in Medical Center/Industry Research Relationships FREE

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This report was approved by the House of Delegates of the American Medical Association in December 1989 as a policy report of the Council on Scientific Affairs and the Council on Ethical and Judicial Affairs.

This report is not intended to be construed or to serve as a standard of medical care. Standards of medical care are determined on the basis of all of the facts and circumstances involved in an individual case and are subject to change as scientific knowledge and technology advance and patterns of practice evolve. This report reflects the views of scientific literature as of November 1989.

Reprint requests to the Council on Scientific Affairs, American Medical Association, 535 N Dearborn St, Chicago, IL 60610 (William R. Hendee, PhD).


JAMA. 1990;263(20):2790-2793. doi:10.1001/jama.1990.03440200094030
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CONFLICT of interest in clinical research defies simple definition: one researcher's conflict of interest may be another's mutually beneficial working relationship.1 Conflict of interest must be clearly distinguished from scientific misconduct. The generally recognized patterns that constitute misconduct in science include plagiarism, deception, falsification, and/or fabrication of scientific data. Scientific misconduct compromises the integrity of the biomedical research process.

On the other hand, conflict of interest involves a distinct subset of issues. Conflict of interest is defined by Webster's Third New International Dictionary as "a conflict between the private interests and official responsibilities of a person in a position of trust." Although conflicts of interest may arise in any research relationship, they are most likely to occur when a researcher enters into a financial arrangement with a profit-making corporation. In that situation, the researcher's dedication to the advancement of medical knowledge may collide with the researcher's desire to increase

REFERENCES

Palca J.  NIH grapples with conflict of interest . Science. 1989;;245:23.
Basic Data Relating to the National Institutes of Health: NIH Data Book . Bethesda, Md: US Dept of Health and Human Services; 1988;.
Hoppin ME.  A university perspective on pharmaceutical and industry support of research . Am J Clin Nutr. 1987;;46:226-228.
Blumenthal D.  University industry research relationships in biotechnology implications for the university . Science. 1986;;232:1361-1366.
Medical Technology Innovation: Prerequisite to Quality Health Care . Chicago, Ill: American Medical Association; 1988;:28. AMA White Paper.
Sterman AB.  A research edge: new teamwork between industry and academia . Pharm Exec. 1988;;8:38-43.
Culliton BJ.  NIH, Inc: the CRADA boom . Science . 1989;;245:1034-1036.
Culliton BJ.  Conflict of interest eyed at Harvard . Science. 1988;;242:1497-1501.
Lundberg GD, Flanagin A.  New requirements for authors: signed statements of authorship responsibility and financial disclosure . JAMA. 1989;;14:2003-2004.

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Palca J.  NIH grapples with conflict of interest . Science. 1989;;245:23.
Basic Data Relating to the National Institutes of Health: NIH Data Book . Bethesda, Md: US Dept of Health and Human Services; 1988;.
Hoppin ME.  A university perspective on pharmaceutical and industry support of research . Am J Clin Nutr. 1987;;46:226-228.
Blumenthal D.  University industry research relationships in biotechnology implications for the university . Science. 1986;;232:1361-1366.
Medical Technology Innovation: Prerequisite to Quality Health Care . Chicago, Ill: American Medical Association; 1988;:28. AMA White Paper.
Sterman AB.  A research edge: new teamwork between industry and academia . Pharm Exec. 1988;;8:38-43.
Culliton BJ.  NIH, Inc: the CRADA boom . Science . 1989;;245:1034-1036.
Culliton BJ.  Conflict of interest eyed at Harvard . Science. 1988;;242:1497-1501.
Lundberg GD, Flanagin A.  New requirements for authors: signed statements of authorship responsibility and financial disclosure . JAMA. 1989;;14:2003-2004.
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