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February 23, 1990, Vol 263, No. 8 >
ARTICLE | February 23, 1990

Cancer Invasion and Metastases FREE

Lance A. Liotta, MD, PhD; Elise Kohn, MD
[+] Author Affiliations

Reprint requests to the Laboratory of Pathology, Bldg 10, Room 2A33, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (Dr Kohn).


JAMA. 1990;263(8):1123-1126. doi:10.1001/jama.1990.03440080101032
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References

SELECTED CASE  EIGHT years ago, a 62-year-old woman sought evaluation for an asymptomatic 2-cm mammographic abnormality in the upper part of the outer quadrant of her left breast. The results of an incisional biopsy were indicative of malignancy. After staging evaluation revealed no distant metastatic disease, she under-went a modified radical mastectomy with axillary node dissection. At the time of pathological review, a 2 × 2-cm estrogen receptor—positive infiltrating ductal adenocarcinoma was found; axillary lymph nodes were free of tumor (stage II, T2, NO, MO).Follow-up was uneventful until presentation 1 year ago, when the patientdeveloped progressive dyspnea on exertion, orthopnea, a dry cough, and a heaviness in the left side of her chest. At the time of examination, she was tachypneic and tachycardiac, and physical findings included dullness to percussion and absent left-sided breath sounds; she was admitted for treatment. A chest roentgenogram showed an opacified left hemithorax and

REFERENCES

1 +
Schirrmacher V.  Cancer metastasis: experimental approaches, theoretical concepts, and impacts for treatment strategies . Adv Cancer Res. 1985;;43:1-73.
2 +
Donegan WL.  Staging and primary treatment . In: Donegan W, Spratt J, eds. Cancer of the Breast. 3rd ed. Philadelphia, Pa: WB Saunders Co; 1988;:336-402.
3 +
Sugarbaker EV.  Patterns of metastasis in human malignancies . Cancer Biol Rev. 1981;;2:235-278.
4 +
Nicolson GL.  Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites . Cancer Metastasis Rev. 1988;;7:143-188.
5 +
Liotta LA.  Tumor invasion: role of the extracellular matrix . Cancer Res. 1986;;46:1-7.
6 +
Rao CN, Margulies IMK, Tralka S, Terranova VP, Madri JA, Liotta LA.  Isolation of a subunit of laminin and its role in molecular structure and tumor cell attachment . J Biol Chem. 1982;;257:9740-9744.
7 +
Liotta LA, Tryggvason K, Garbisa S, Hart I, Foltz C, Shafie S.  Metastatic potential correlates with enzymatic degradation of basement membrane collagen . Nature. 1980;;284:67-68.
8 +
Liotta LA, Mandler R, Murano G, et al.  Tumor cell autocrine motility factor . Proc Nati Acad Sci USA. 1986;;83:3302-3306.
9 +
Engel J, Odermatt E, Engel A, et al.  Shapes, domain organization and flexibility of laminin and fibronectin: two multifunctional proteins of the extracellular matrix . Mol Biol. 1981;;150:97-120.
10 +
Wewer UM, Taraboletti G, Sobel ME, Albrechtsen R, Liotta LA.  Laminin receptor: role in tumor cell migration . Cancer Res. 1987;;47:5691-5698.
11 +
Barsky SH, Rao CN, Williams JE, Liotta LA.  Laminin molecular domains which alter metastasis in a murine model . J Clin Invest. 1984;;74:843-848.
12 +
McCarthy JB, Skubitz APN, Palm SL, Furcht LT.  Metastasis inhibition of different tumor types by purified laminin fragments and a heparin-binding fragment of fibronectin . JNCI. 1988;;80:108-116.
13 +
Wewer UM, Liotta LA, Jaye M, et al.  Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to bind laminin . Proc Natl Acad Sci USA. 1986;;83:7137-7141.
14 +
Collier IE, Wilhelm SM, Eisen AZ, et al.  H-ras oncogene transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen . J Biol Chem. 1988;;263:6579-6587.
15 +
Hoyhtya M, Turpeenniemi-Hujanen T, Stetler-Stevenson WG, Krutsch H, Tryggvason K, Liotta LA.  Monoclonal antibodies to type IV collagenase recognize a protein with limited sequence homology to interstitial collagenase and stromelysin . FEBS Lett. 1988;;233:109-113.
16 +
Stetler-Stevenson WG, Krutzsch HC, Wacher MP, Margulies IMK, Liotta LA.  The activation of human type IV collagenase proenzyme: sequence identification of the major conversion product following organomercurial activation . J Biol Chem. 1989;;264:1353-1356.
17 +
Guirguis R, Schiffmann E, Liu B, Birkbeck D, Engel J, Liotta LA.  Detection of autocrine motility factor(s) in urine as markers of bladder cancer . JNCI. 1988;;80:1203-1211.
18 +
Muschel R, Liotta LA.  Role of oncogenes in metastases . Carcinogenesis. 1988;;9:705-710.
19 +
Pozzatti RP, Muschel RJ, Williams JR, Howard B, Liotta LA, Khoury G.  Primary rat embryo cells transformed by one or two oncogenes show different metastatic potentials . Science. 1986;; 232:223-227.
20 +
Garbisa A, Pozzatti R, Muschel RJ, et al.  Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not c-Ha-ras plus AD2-Ela . Cancer Res. 1987;;47:1523-1528.
21 +
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL.  Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene . Science. 1987;; 235:177-182.
22 +
Lidereau R, Callahan R, Dickson C, Peters G, Escort C, Ali IU.  Amplification of the int-2 gene in primary human breast tumors . Oncogene Res. 1988;;2:285-291.
23 +
Ali IU, Lidereau R, Theillet C, Callahan R.  Reduction to homozygosity of genes on chromosome 11 in human breast neoplasia . Science. 1987;;238:185-188.
24 +
Vogelstein B, Fearon ER, Hamilton SR, et al.  Genetic alterations during colorectal tumor development . NEngl J Med. 1988;;319:525-532.
25 +
Baker SJ, Fearon ER, Nigro JM, et al.  Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas . Science. 1989;;244:217-221.
26 +
Steeg PS, Bevilacqua G, Koper L, et al.  Evidence for a novel gene associated with low tumor metastatic potential . JNCI. 1988;;80:200-204.
27 +
Rosengard AM, Krutsch HC, Shearn A, et al.  Reduced Nm23/Awd protein in tumor metastasis and aberrant Drosophila development . Nature. 1989;;342:177-180.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Schirrmacher V.  Cancer metastasis: experimental approaches, theoretical concepts, and impacts for treatment strategies . Adv Cancer Res. 1985;;43:1-73.
2 +
Donegan WL.  Staging and primary treatment . In: Donegan W, Spratt J, eds. Cancer of the Breast. 3rd ed. Philadelphia, Pa: WB Saunders Co; 1988;:336-402.
3 +
Sugarbaker EV.  Patterns of metastasis in human malignancies . Cancer Biol Rev. 1981;;2:235-278.
4 +
Nicolson GL.  Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites . Cancer Metastasis Rev. 1988;;7:143-188.
5 +
Liotta LA.  Tumor invasion: role of the extracellular matrix . Cancer Res. 1986;;46:1-7.
6 +
Rao CN, Margulies IMK, Tralka S, Terranova VP, Madri JA, Liotta LA.  Isolation of a subunit of laminin and its role in molecular structure and tumor cell attachment . J Biol Chem. 1982;;257:9740-9744.
7 +
Liotta LA, Tryggvason K, Garbisa S, Hart I, Foltz C, Shafie S.  Metastatic potential correlates with enzymatic degradation of basement membrane collagen . Nature. 1980;;284:67-68.
8 +
Liotta LA, Mandler R, Murano G, et al.  Tumor cell autocrine motility factor . Proc Nati Acad Sci USA. 1986;;83:3302-3306.
9 +
Engel J, Odermatt E, Engel A, et al.  Shapes, domain organization and flexibility of laminin and fibronectin: two multifunctional proteins of the extracellular matrix . Mol Biol. 1981;;150:97-120.
10 +
Wewer UM, Taraboletti G, Sobel ME, Albrechtsen R, Liotta LA.  Laminin receptor: role in tumor cell migration . Cancer Res. 1987;;47:5691-5698.
11 +
Barsky SH, Rao CN, Williams JE, Liotta LA.  Laminin molecular domains which alter metastasis in a murine model . J Clin Invest. 1984;;74:843-848.
12 +
McCarthy JB, Skubitz APN, Palm SL, Furcht LT.  Metastasis inhibition of different tumor types by purified laminin fragments and a heparin-binding fragment of fibronectin . JNCI. 1988;;80:108-116.
13 +
Wewer UM, Liotta LA, Jaye M, et al.  Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to bind laminin . Proc Natl Acad Sci USA. 1986;;83:7137-7141.
14 +
Collier IE, Wilhelm SM, Eisen AZ, et al.  H-ras oncogene transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen . J Biol Chem. 1988;;263:6579-6587.
15 +
Hoyhtya M, Turpeenniemi-Hujanen T, Stetler-Stevenson WG, Krutsch H, Tryggvason K, Liotta LA.  Monoclonal antibodies to type IV collagenase recognize a protein with limited sequence homology to interstitial collagenase and stromelysin . FEBS Lett. 1988;;233:109-113.
16 +
Stetler-Stevenson WG, Krutzsch HC, Wacher MP, Margulies IMK, Liotta LA.  The activation of human type IV collagenase proenzyme: sequence identification of the major conversion product following organomercurial activation . J Biol Chem. 1989;;264:1353-1356.
17 +
Guirguis R, Schiffmann E, Liu B, Birkbeck D, Engel J, Liotta LA.  Detection of autocrine motility factor(s) in urine as markers of bladder cancer . JNCI. 1988;;80:1203-1211.
18 +
Muschel R, Liotta LA.  Role of oncogenes in metastases . Carcinogenesis. 1988;;9:705-710.
19 +
Pozzatti RP, Muschel RJ, Williams JR, Howard B, Liotta LA, Khoury G.  Primary rat embryo cells transformed by one or two oncogenes show different metastatic potentials . Science. 1986;; 232:223-227.
20 +
Garbisa A, Pozzatti R, Muschel RJ, et al.  Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not c-Ha-ras plus AD2-Ela . Cancer Res. 1987;;47:1523-1528.
21 +
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL.  Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene . Science. 1987;; 235:177-182.
22 +
Lidereau R, Callahan R, Dickson C, Peters G, Escort C, Ali IU.  Amplification of the int-2 gene in primary human breast tumors . Oncogene Res. 1988;;2:285-291.
23 +
Ali IU, Lidereau R, Theillet C, Callahan R.  Reduction to homozygosity of genes on chromosome 11 in human breast neoplasia . Science. 1987;;238:185-188.
24 +
Vogelstein B, Fearon ER, Hamilton SR, et al.  Genetic alterations during colorectal tumor development . NEngl J Med. 1988;;319:525-532.
25 +
Baker SJ, Fearon ER, Nigro JM, et al.  Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas . Science. 1989;;244:217-221.
26 +
Steeg PS, Bevilacqua G, Koper L, et al.  Evidence for a novel gene associated with low tumor metastatic potential . JNCI. 1988;;80:200-204.
27 +
Rosengard AM, Krutsch HC, Shearn A, et al.  Reduced Nm23/Awd protein in tumor metastasis and aberrant Drosophila development . Nature. 1989;;342:177-180.

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