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Benzodiazepines and Hip Fracture-Reply FREE

Wayne A. Ray, PhD; Marie R. Griffin, PhD
JAMA. 1990;263(24):3261-3261. doi:10.1001/jama.1990.03440240044014
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In Reply. —  Mr Jacobs and Ms Das raise six questions concerning our study. (1) Is the point prevalence of current long-half-life benzodiazepine use in the case subjects different from that of the entire elderly population in Saskatchewan? (2) Does a direct comparison between long- and short—half-life benzodiazepine users show a difference in hip fracture risk? (3) Does use of diazepam for convulsions result in confounding? (4) Should other fall-related injuries have been included as outcomes? (5) Do nonsignificant differences in confounder prevalence for sampled cases that would have been significant in a larger sample indicate inadequate confounder control? (6) Can we rule out any spurious association, particularly with regard to mental impairment?

  1. One of the strengths of this study is that control subjects were sampled randomly from the entire elderly Saskatchewan population of persons without hip fractures, with stratification by demographic characteristics associated with both benzodiazepine use and

REFERENCES

National Disease and Therapeutic Index . Plymouth Meeting, Pa: IMS America Ltd; 1989;.
Cummings SR, Kelsey JL, Nevitt MC, O'Dowd RJ.  Epidemiology of osteoporosis and osteoporotic fractures . Epidemiol Rev. 1985;;7:178-208.
Ray WA, Griffin MR, Schaffner W, Baugh DK, Melton LJ III.  Psychotropic drug use and the risk of hip fracture . N Engl J Med. 1987;;316:363-369.
Tinetti ME, Speechley M, Gintai SF.  Risk factors for falls among elderly persons living in the community . N Engl J Med. 1988;;319:1701-1707.
Ray WA, Griffin MR.  Prescribed medications and the risk of falling . Top Geriatr Rehabil. 1990;:5:12-20.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

National Disease and Therapeutic Index . Plymouth Meeting, Pa: IMS America Ltd; 1989;.
Cummings SR, Kelsey JL, Nevitt MC, O'Dowd RJ.  Epidemiology of osteoporosis and osteoporotic fractures . Epidemiol Rev. 1985;;7:178-208.
Ray WA, Griffin MR, Schaffner W, Baugh DK, Melton LJ III.  Psychotropic drug use and the risk of hip fracture . N Engl J Med. 1987;;316:363-369.
Tinetti ME, Speechley M, Gintai SF.  Risk factors for falls among elderly persons living in the community . N Engl J Med. 1988;;319:1701-1707.
Ray WA, Griffin MR.  Prescribed medications and the risk of falling . Top Geriatr Rehabil. 1990;:5:12-20.
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