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Relative Weight, Height, and Risk of Breast Cancer-Reply FREE

W. C. Willett, MD; M. J. Stampfer, MD; F. E. Speizer, MD; G. A. Colditz, MD; B. Rosner, PhD; S. J. London, MD
JAMA. 1990;263(23):3148-3148. doi:10.1001/jama.1990.03440230044016
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In Reply.—  Drs Albanes and Brown raise concern about confounding by height in our study because we used BMI at weight divided by height raised to the second power rather than as weight divided by height to the 1.5 power. No appreciable confounding could occur because the correlation between height and BMI is -.03 in our study. Even if the relation between height and BMI was similar to that in his study (r = -. 12), our results still would not be appreciably distorted as the association of height and breast cancer was very weak (for extreme categories, the relative risk was 1.1 in premenopausal women and 1.3 in postmenopausal women).The emphasis on uncorrelatedness with height as a criterion for an obesity index is an anachronism from before the computer era. The primary criterion should be maximal correlation with either absolute or relative body fat mass; there is no evidence that

REFERENCES

Willett WC. Nutritional Epidemiology . New York, NY: Oxford University Press; 1989;.
Tretli S.  Height and weight in relation to breast cancer morbidity and mortality: a prospective study of 570 000 women in Norway . Int J Cancer. 1989;;44:23-30.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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Willett WC. Nutritional Epidemiology . New York, NY: Oxford University Press; 1989;.
Tretli S.  Height and weight in relation to breast cancer morbidity and mortality: a prospective study of 570 000 women in Norway . Int J Cancer. 1989;;44:23-30.
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