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June 13, 1990, Vol 263, No. 22 >
ARTICLE | June 13, 1990

Flaviviruses and Bone Marrow Failure FREE

Neal S. Young, MD
[+] Author Affiliations

Reprint requests to National Institutes of Health, Bldg 10/Room 7C103, Bethesda, MD 20892 (Dr Young).


JAMA. 1990;263(22):3065-3068. doi:10.1001/jama.1990.03440220089037
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References

SELECTED CASE  IN MARCH 1989, a 21-year-old army private was transferred to the Clinical Center for treatment of aplastic anemia. He had been well until October 1988, when he had a serologically documented episode of hepatitis B; symptoms of malaise and lethargy persisted until January 1989, when he developed nose bleeds, gum oozing, and easy bruising. In early February 1989, peripheral blood cell counts were obtained: hematocrit, 0.18; leukocyte count, 1.1×109/L; and platelet count, 8 × 109/L. A bone marrow was acellular. Fever developed, and administration of antibiotics was begun empirically. He was transferred from his base in Italy to Walter Reed Army Medical Center, Washington, DC, where serological studies revealed antibodies to hepatitis B core and surface antigens and to hepatitis A but no hepatitis B core antigen or IgM antibody to core antigen. Administration of antibiotics was discontinued without recurrence of fever, and he

REFERENCES

1 +
Baranski B, Young N.  Hematologic manifestations of viral illness . Hematol Oncol Clin North Am. 1987;;1:167-183.
2 +
Kurtzman G, Young N.  Virus-associated bone marrow failure . Clin Haematol. 1989;;2:51-68.
3 +
Young N.  Hematologic and hematopoietic consequences of B19 parvovirus infection . Semin Hematol. 1988;;25:159-172.
4 +
Frickhofen N, Young NS.  Persistent parvovirus B19 infections in humans . Microb Pathog. 1989;;7: 319-327.
5 +
Baranski B, Armstrong G, Truman JT, Quinnan GV, Straus SE, Young NS.  Epstein-Barr virus in the bone marrow of patients with aplastic anemia . Ann Intern Med. 1988;;109:695-704.
6 +
Apperley JF, Dowding C, Hibbin J, et al.  The effect of cytomegalovirus on hemopoiesis: in vitro evidence for selective infection of marrow stromal cells . Exp Hematol. 1989;;17:38-45.
7 +
Kurtzman GJ, Platanias L, Lustig L, Frickhofen N, Young NS.  Feline parvovirus propagates in cat bone marrow cultures and inhibits hematopoietic colony formation in vitro . Blood. 1989;;74:71-81.
8 +
Hardy WD Jr, Essex M, McClelland AJ. Feline Leukemia Virus . New York, NY: Elsevier Science Publishing Co Inc; 1980;.
9 +
Hagler L, Pastore RA, Bergin JJ, Wrensch MR.  Aplastic anemia following viral hepatitis: report of two fatal cases and literature review . Medicine. 1975;;54:139-164.
10 +
Zeldis JB, Dienstag JL, Gale RP.  Aplastic anemia and non-A, non-B hepatitis . Am J Med. 1983;;74:64-68.
11 +
Tzakis AG, Arditi M, Whitington PF, et al.  Aplastic anemia complicating orthotropic liver transplantation for non-A, non-B hepatitis . N Engl J Med. 1988;;319:393-396.
12 +
Camitta BM, Storb R, Thomas ED.  Aplastic anemia. Pathogenesis, diagnosis, treatment, and prognosis . N Engl J Med. 1982;;306:645-652, 712-718.
13 +
Young NS, Issaragrasil S, Ch'en WC, Takaku F.  Aplastic anemia in the Orient . Br J Haematol. 1986;;62:1-6.
14 +
Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M.  Isolation of cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome . Science. 1989;;244:359-364.
15 +
Monath TP.  Pathobiology of the flaviviruses . In: Schlesinger S, Schlesinger MJ, eds. The Togaviridae and Flaviviridae . New York, NY: Plenum Press; 1986;:375-440.
16 +
Halstead SB.  Dengue: hematologic aspects . Semin Hematol. 1982;;19:116-131.
17 +
Bierman HR, Nelson ER.  Hematodepressive diseases of Thailand . Ann Intern Med. 1965;;62:867-884.
18 +
Johnson KM, Halstead SB, Cohen SM.  Hemorrhagic fevers of Southeast Asia and South America: a comparative appraisal . Prog Med Virol. 1967;;9: 106-113.
19 +
Tigertt WD, Crosby WH, Berge TO, et al.  The virus of Venezuelan equine encephalomyelitis as an antineoplastic agent in man . Cancer. 1962;;15:628-632.
20 +
Smith TJ, McKinney RW, Sawyer WD.  Isolation of Venezuelan equine encephalomyelitis virus by bone marrow culture . Proc Soc Exp Biol Med. 1964;;117:271.
21 +
Nakao S, Lai C-J, Young NS.  Dengue virus, a flavivirus, propagates in human bone marrow progenitors and hematopoietic cell lines . Blood. 1989;;74:1235-1240.
22 +
Kurane I, Meager A, Ennis FA.  Dengue virus-specific human T cell clones: serotype crossreactive proliferation, interferon gamma production, and cytotoxic activity . J Exp Med. 1989;;170:763-775.
23 +
Young NS, Alter BA.  Bone marrow failure . In: Blood: Principles and Practice of Hematology . Philadelphia, Pa: JB Lippincott. In press.
24 +
Monath TP.  Flaviviruses . In: Fields BN, Knipe DM, Melnick JL, Channock RM, Roizman B, Shope RE, eds. Virology . New York, NY: Raven Press; 1985;:955-1004.
25 +
Brinton MA, Blank KJ, Nathanson N.  Host genes that influence susceptibility to viral diseases . In: Notkins AL, Oldstone MBA, eds. Concepts in Viral Pathogenesis . New York, NY: Springer-Verlag NY Inc; 1984;:71-78.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Baranski B, Young N.  Hematologic manifestations of viral illness . Hematol Oncol Clin North Am. 1987;;1:167-183.
2 +
Kurtzman G, Young N.  Virus-associated bone marrow failure . Clin Haematol. 1989;;2:51-68.
3 +
Young N.  Hematologic and hematopoietic consequences of B19 parvovirus infection . Semin Hematol. 1988;;25:159-172.
4 +
Frickhofen N, Young NS.  Persistent parvovirus B19 infections in humans . Microb Pathog. 1989;;7: 319-327.
5 +
Baranski B, Armstrong G, Truman JT, Quinnan GV, Straus SE, Young NS.  Epstein-Barr virus in the bone marrow of patients with aplastic anemia . Ann Intern Med. 1988;;109:695-704.
6 +
Apperley JF, Dowding C, Hibbin J, et al.  The effect of cytomegalovirus on hemopoiesis: in vitro evidence for selective infection of marrow stromal cells . Exp Hematol. 1989;;17:38-45.
7 +
Kurtzman GJ, Platanias L, Lustig L, Frickhofen N, Young NS.  Feline parvovirus propagates in cat bone marrow cultures and inhibits hematopoietic colony formation in vitro . Blood. 1989;;74:71-81.
8 +
Hardy WD Jr, Essex M, McClelland AJ. Feline Leukemia Virus . New York, NY: Elsevier Science Publishing Co Inc; 1980;.
9 +
Hagler L, Pastore RA, Bergin JJ, Wrensch MR.  Aplastic anemia following viral hepatitis: report of two fatal cases and literature review . Medicine. 1975;;54:139-164.
10 +
Zeldis JB, Dienstag JL, Gale RP.  Aplastic anemia and non-A, non-B hepatitis . Am J Med. 1983;;74:64-68.
11 +
Tzakis AG, Arditi M, Whitington PF, et al.  Aplastic anemia complicating orthotropic liver transplantation for non-A, non-B hepatitis . N Engl J Med. 1988;;319:393-396.
12 +
Camitta BM, Storb R, Thomas ED.  Aplastic anemia. Pathogenesis, diagnosis, treatment, and prognosis . N Engl J Med. 1982;;306:645-652, 712-718.
13 +
Young NS, Issaragrasil S, Ch'en WC, Takaku F.  Aplastic anemia in the Orient . Br J Haematol. 1986;;62:1-6.
14 +
Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M.  Isolation of cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome . Science. 1989;;244:359-364.
15 +
Monath TP.  Pathobiology of the flaviviruses . In: Schlesinger S, Schlesinger MJ, eds. The Togaviridae and Flaviviridae . New York, NY: Plenum Press; 1986;:375-440.
16 +
Halstead SB.  Dengue: hematologic aspects . Semin Hematol. 1982;;19:116-131.
17 +
Bierman HR, Nelson ER.  Hematodepressive diseases of Thailand . Ann Intern Med. 1965;;62:867-884.
18 +
Johnson KM, Halstead SB, Cohen SM.  Hemorrhagic fevers of Southeast Asia and South America: a comparative appraisal . Prog Med Virol. 1967;;9: 106-113.
19 +
Tigertt WD, Crosby WH, Berge TO, et al.  The virus of Venezuelan equine encephalomyelitis as an antineoplastic agent in man . Cancer. 1962;;15:628-632.
20 +
Smith TJ, McKinney RW, Sawyer WD.  Isolation of Venezuelan equine encephalomyelitis virus by bone marrow culture . Proc Soc Exp Biol Med. 1964;;117:271.
21 +
Nakao S, Lai C-J, Young NS.  Dengue virus, a flavivirus, propagates in human bone marrow progenitors and hematopoietic cell lines . Blood. 1989;;74:1235-1240.
22 +
Kurane I, Meager A, Ennis FA.  Dengue virus-specific human T cell clones: serotype crossreactive proliferation, interferon gamma production, and cytotoxic activity . J Exp Med. 1989;;170:763-775.
23 +
Young NS, Alter BA.  Bone marrow failure . In: Blood: Principles and Practice of Hematology . Philadelphia, Pa: JB Lippincott. In press.
24 +
Monath TP.  Flaviviruses . In: Fields BN, Knipe DM, Melnick JL, Channock RM, Roizman B, Shope RE, eds. Virology . New York, NY: Raven Press; 1985;:955-1004.
25 +
Brinton MA, Blank KJ, Nathanson N.  Host genes that influence susceptibility to viral diseases . In: Notkins AL, Oldstone MBA, eds. Concepts in Viral Pathogenesis . New York, NY: Springer-Verlag NY Inc; 1984;:71-78.

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